Linderapyrone analogue LPD-01 as a cancer treatment agent by targeting importin7

The Wnt/ β -catenin signaling pathway plays important roles in several cancer cells, including cell proliferation and development. We previously succeeded in synthesizing a small molecule compound inhibiting the Wnt/ β -catenin signaling pathway, named LPD-01 ( 1 ), and 1 inhibited the growth of hum...

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Veröffentlicht in:	Journal of natural medicines 2024-03, Vol.78 (2), p.370-381
Hauptverfasser:	Kitagawa, Takahiro, Matsumoto, Takahiro, Ohta, Tomoe, Yoshida, Tatsusada, Saito, Youhei, Nakayama, Yuji, Hadate, Yuki, Ashihara, Eishi, Watanabe, Tetsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine c-Myc protein Cancer therapies Cell proliferation Colorectal cancer Colorectal carcinoma Complementary & Alternative Medicine Mass spectroscopy Medicinal Chemistry Myc protein Nuclear transport Original Paper Pharmacology/Toxicology Pharmacy Plant Sciences Proteins Signal transduction siRNA Smad2 protein Smad3 protein Survivin Transforming growth factor-b Wnt protein β-Catenin
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