Personalized Chronomodulated 5‐Fluorouracil Treatment: A Physiologically‐Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy

The discovery of circadian clock genes greatly amplified the study of diurnal variations impacting cancer therapy, transforming it into a rapidly growing field of research. Especially, use of chronomodulated treatment with 5‐fluorouracil (5‐FU) has gained significance. Studies indicate high interind...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2024-06, Vol.115 (6), p.1282-1292
Hauptverfasser:	Marok, Fatima Zahra, Wojtyniak, Jan‐Georg, Selzer, Dominik, Dallmann, Robert, Swen, Jesse J., Guchelaar, Henk‐Jan, Schwab, Matthias, Lehr, Thorsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - pharmacokinetics Circadian Rhythm - physiology Computer Simulation Dihydrouracil Dehydrogenase (NADP) - genetics Dihydrouracil Dehydrogenase (NADP) - metabolism Drug Chronotherapy Female Fluorouracil - administration & dosage Fluorouracil - pharmacokinetics Humans Male Middle Aged Models, Biological Neoplasms - drug therapy Precision Medicine - methods Uracil - administration & dosage Uracil - analogs & derivatives Uracil - pharmacokinetics
Online-Zugang:	Volltext
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