Cone-beam computed tomography-guided online adaptive radiotherapy for pharyngeal cancer with whole neck irradiation: dose-volume histogram analysis between adapted and scheduled plans
Abstract The present study aimed to evaluate whether an adapted plan with Ethos™ could be used for pharyngeal cancer. Ten patients with pharyngeal cancer who underwent chemoradiotherapy with available daily cone-beam computed tomography (CBCT) data were included. Simulated treatments were generated...
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| Veröffentlicht in: | Journal of radiation research 2024-03, Vol.65 (2), p.223-230 |
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| creator | Uehara, Takuya Nishimura, Yasumasa Ishikawa, Kazuki Inada, Masahiro Matsumoto, Kenji Doi, Hiroshi Monzen, Hajime Matsuo, Yukinori |
| description | Abstract
The present study aimed to evaluate whether an adapted plan with Ethos™ could be used for pharyngeal cancer. Ten patients with pharyngeal cancer who underwent chemoradiotherapy with available daily cone-beam computed tomography (CBCT) data were included. Simulated treatments were generated on the Ethos™ treatment emulator using CBCTs every four to five fractions for two plans: adapted and scheduled. The simulated treatments were divided into three groups: early (first–second week), middle (third–fourth week), and late (fifth–seventh week) periods. Dose-volume histogram parameters were compared for each period between the adapted and scheduled plans in terms of the planning target volume (PTV) (D98%, D95%, D50% and D2%), spinal cord (Dmax and D1cc), brainstem (Dmax) and ipsilateral and contralateral parotid glands (Dmedian and Dmean). The PTV D98%, D95% and D2% of the adapted plan were significantly higher than those of the scheduled plans in all periods, except for D98% in the late period. The adapted plan significantly reduced the spinal cord Dmax and D1cc compared with the scheduled plan in all periods. Ipsilateral and contralateral parotid glands Dmean of the adapted plan were lower than those of scheduled plan in the late period. In conclusion, the present study revealed that the adapted plans could maintain PTV coverage while reducing the doses to organs at risk in each period compared with scheduled plans. |
| doi_str_mv | 10.1093/jrr/rrad103 |
| format | Article |
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The present study aimed to evaluate whether an adapted plan with Ethos™ could be used for pharyngeal cancer. Ten patients with pharyngeal cancer who underwent chemoradiotherapy with available daily cone-beam computed tomography (CBCT) data were included. Simulated treatments were generated on the Ethos™ treatment emulator using CBCTs every four to five fractions for two plans: adapted and scheduled. The simulated treatments were divided into three groups: early (first–second week), middle (third–fourth week), and late (fifth–seventh week) periods. Dose-volume histogram parameters were compared for each period between the adapted and scheduled plans in terms of the planning target volume (PTV) (D98%, D95%, D50% and D2%), spinal cord (Dmax and D1cc), brainstem (Dmax) and ipsilateral and contralateral parotid glands (Dmedian and Dmean). The PTV D98%, D95% and D2% of the adapted plan were significantly higher than those of the scheduled plans in all periods, except for D98% in the late period. The adapted plan significantly reduced the spinal cord Dmax and D1cc compared with the scheduled plan in all periods. Ipsilateral and contralateral parotid glands Dmean of the adapted plan were lower than those of scheduled plan in the late period. In conclusion, the present study revealed that the adapted plans could maintain PTV coverage while reducing the doses to organs at risk in each period compared with scheduled plans.</description><identifier>ISSN: 0449-3060</identifier><identifier>EISSN: 1349-9157</identifier><identifier>DOI: 10.1093/jrr/rrad103</identifier><identifier>PMID: 38264828</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Cancer ; Care and treatment ; Cone-Beam Computed Tomography ; CT imaging ; Humans ; International economic relations ; Medical equipment and supplies industry ; Medical test kit industry ; Organs at Risk ; Pharyngeal Neoplasms ; Radiation ; Radiotherapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - methods ; Radiotherapy, Intensity-Modulated - methods ; Throat cancer</subject><ispartof>Journal of radiation research, 2024-03, Vol.65 (2), p.223-230</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. 2024</rights><rights>The Author(s) 2024. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.</rights><rights>COPYRIGHT 2024 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c382t-7702c98137103fc8b7f8018cf48f24d15481a2226bf706f3a59666a7dfabab323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,1598,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38264828$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uehara, Takuya</creatorcontrib><creatorcontrib>Nishimura, Yasumasa</creatorcontrib><creatorcontrib>Ishikawa, Kazuki</creatorcontrib><creatorcontrib>Inada, Masahiro</creatorcontrib><creatorcontrib>Matsumoto, Kenji</creatorcontrib><creatorcontrib>Doi, Hiroshi</creatorcontrib><creatorcontrib>Monzen, Hajime</creatorcontrib><creatorcontrib>Matsuo, Yukinori</creatorcontrib><title>Cone-beam computed tomography-guided online adaptive radiotherapy for pharyngeal cancer with whole neck irradiation: dose-volume histogram analysis between adapted and scheduled plans</title><title>Journal of radiation research</title><addtitle>J Radiat Res</addtitle><description>Abstract
The present study aimed to evaluate whether an adapted plan with Ethos™ could be used for pharyngeal cancer. Ten patients with pharyngeal cancer who underwent chemoradiotherapy with available daily cone-beam computed tomography (CBCT) data were included. Simulated treatments were generated on the Ethos™ treatment emulator using CBCTs every four to five fractions for two plans: adapted and scheduled. The simulated treatments were divided into three groups: early (first–second week), middle (third–fourth week), and late (fifth–seventh week) periods. Dose-volume histogram parameters were compared for each period between the adapted and scheduled plans in terms of the planning target volume (PTV) (D98%, D95%, D50% and D2%), spinal cord (Dmax and D1cc), brainstem (Dmax) and ipsilateral and contralateral parotid glands (Dmedian and Dmean). The PTV D98%, D95% and D2% of the adapted plan were significantly higher than those of the scheduled plans in all periods, except for D98% in the late period. The adapted plan significantly reduced the spinal cord Dmax and D1cc compared with the scheduled plan in all periods. Ipsilateral and contralateral parotid glands Dmean of the adapted plan were lower than those of scheduled plan in the late period. In conclusion, the present study revealed that the adapted plans could maintain PTV coverage while reducing the doses to organs at risk in each period compared with scheduled plans.</description><subject>Cancer</subject><subject>Care and treatment</subject><subject>Cone-Beam Computed Tomography</subject><subject>CT imaging</subject><subject>Humans</subject><subject>International economic relations</subject><subject>Medical equipment and supplies industry</subject><subject>Medical test kit industry</subject><subject>Organs at Risk</subject><subject>Pharyngeal Neoplasms</subject><subject>Radiation</subject><subject>Radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>Radiotherapy, Intensity-Modulated - methods</subject><subject>Throat cancer</subject><issn>0449-3060</issn><issn>1349-9157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNp9kt-L1DAQx4Mo3nr65LsEBBGkd0nbTdN7OxZ_wYEv-lymyWSbs01qkt6yf5n_nim7CoJIHpIZPjPfycwQ8pKzK87a6vo-hOsQQHNWPSIbXtVt0fJt85hsWJ3fFRPsgjyL8Z6xsmFb9pRcVLIUtSzlhvzceYdFjzBR5ad5Sahp8pPfB5iHY7FfrM4e70brkIKGOdkHpFnN-jRgho7U-EDnAcLR7RFGqsApDPRg00APgx-ROlTfqV1LtJCsdzdU-4jFgx-XCelgY1rlJgoOxmO0kfaYDojupJflwWka1YB6GbM1j-Dic_LEwBjxxfm-JN8-vP-6-1Tcffn4eXd7V6j8x1Q0DStVK3nV5O4YJfvGSMalMrU0Za35tpYcyrIUvWmYMBVsWyEENNpAD31VVpfk7SnvHPyPBWPqJhsVjrkG9EvsypZL3opKrOjrE7qHETvrjE8B1Ip3t41sRV3nUWTq6h9UPhonq_IwjM3-vwLenQJU8DEGNN0c7JTb3XHWrQvQ5QXozguQ6Vfnepd-Qv2H_T3xDLw5AX6Z_5vpF7ASvaw</recordid><startdate>20240322</startdate><enddate>20240322</enddate><creator>Uehara, Takuya</creator><creator>Nishimura, Yasumasa</creator><creator>Ishikawa, Kazuki</creator><creator>Inada, Masahiro</creator><creator>Matsumoto, Kenji</creator><creator>Doi, Hiroshi</creator><creator>Monzen, Hajime</creator><creator>Matsuo, Yukinori</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240322</creationdate><title>Cone-beam computed tomography-guided online adaptive radiotherapy for pharyngeal cancer with whole neck irradiation: dose-volume histogram analysis between adapted and scheduled plans</title><author>Uehara, Takuya ; Nishimura, Yasumasa ; Ishikawa, Kazuki ; Inada, Masahiro ; Matsumoto, Kenji ; Doi, Hiroshi ; Monzen, Hajime ; Matsuo, Yukinori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-7702c98137103fc8b7f8018cf48f24d15481a2226bf706f3a59666a7dfabab323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cancer</topic><topic>Care and treatment</topic><topic>Cone-Beam Computed Tomography</topic><topic>CT imaging</topic><topic>Humans</topic><topic>International economic relations</topic><topic>Medical equipment and supplies industry</topic><topic>Medical test kit industry</topic><topic>Organs at Risk</topic><topic>Pharyngeal Neoplasms</topic><topic>Radiation</topic><topic>Radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted - methods</topic><topic>Radiotherapy, Intensity-Modulated - methods</topic><topic>Throat cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uehara, Takuya</creatorcontrib><creatorcontrib>Nishimura, Yasumasa</creatorcontrib><creatorcontrib>Ishikawa, Kazuki</creatorcontrib><creatorcontrib>Inada, Masahiro</creatorcontrib><creatorcontrib>Matsumoto, Kenji</creatorcontrib><creatorcontrib>Doi, Hiroshi</creatorcontrib><creatorcontrib>Monzen, Hajime</creatorcontrib><creatorcontrib>Matsuo, Yukinori</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uehara, Takuya</au><au>Nishimura, Yasumasa</au><au>Ishikawa, Kazuki</au><au>Inada, Masahiro</au><au>Matsumoto, Kenji</au><au>Doi, Hiroshi</au><au>Monzen, Hajime</au><au>Matsuo, Yukinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cone-beam computed tomography-guided online adaptive radiotherapy for pharyngeal cancer with whole neck irradiation: dose-volume histogram analysis between adapted and scheduled plans</atitle><jtitle>Journal of radiation research</jtitle><addtitle>J Radiat Res</addtitle><date>2024-03-22</date><risdate>2024</risdate><volume>65</volume><issue>2</issue><spage>223</spage><epage>230</epage><pages>223-230</pages><issn>0449-3060</issn><eissn>1349-9157</eissn><abstract>Abstract
The present study aimed to evaluate whether an adapted plan with Ethos™ could be used for pharyngeal cancer. Ten patients with pharyngeal cancer who underwent chemoradiotherapy with available daily cone-beam computed tomography (CBCT) data were included. Simulated treatments were generated on the Ethos™ treatment emulator using CBCTs every four to five fractions for two plans: adapted and scheduled. The simulated treatments were divided into three groups: early (first–second week), middle (third–fourth week), and late (fifth–seventh week) periods. Dose-volume histogram parameters were compared for each period between the adapted and scheduled plans in terms of the planning target volume (PTV) (D98%, D95%, D50% and D2%), spinal cord (Dmax and D1cc), brainstem (Dmax) and ipsilateral and contralateral parotid glands (Dmedian and Dmean). The PTV D98%, D95% and D2% of the adapted plan were significantly higher than those of the scheduled plans in all periods, except for D98% in the late period. The adapted plan significantly reduced the spinal cord Dmax and D1cc compared with the scheduled plan in all periods. Ipsilateral and contralateral parotid glands Dmean of the adapted plan were lower than those of scheduled plan in the late period. In conclusion, the present study revealed that the adapted plans could maintain PTV coverage while reducing the doses to organs at risk in each period compared with scheduled plans.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>38264828</pmid><doi>10.1093/jrr/rrad103</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Cancer Care and treatment Cone-Beam Computed Tomography CT imaging Humans International economic relations Medical equipment and supplies industry Medical test kit industry Organs at Risk Pharyngeal Neoplasms Radiation Radiotherapy Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Intensity-Modulated - methods Throat cancer |
| title | Cone-beam computed tomography-guided online adaptive radiotherapy for pharyngeal cancer with whole neck irradiation: dose-volume histogram analysis between adapted and scheduled plans |
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