Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton’s Tyrosine Kinase (BTK) Degrader CD79b Targeted Antibody–Drug Conjugates

Antibody–drug conjugates (ADCs) are an established modality that allow for targeted delivery of a potent molecule, or payload, to a desired site of action. ADCs, wherein the payload is a targeted protein degrader, are an emerging area in the field. Herein we describe our efforts of delivering a Brut...

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Veröffentlicht in:	Bioconjugate chemistry 2024-02, Vol.35 (2), p.140-146
Hauptverfasser:	Zhang, Alan, Seiss, Katherine, Laborde, Laurent, Palacio-Ramirez, Sebastian, Guthy, Daniel, Lanter, Mylene, Lorber, Julien, Vulpetti, Anna, Arista, Luca, Zoller, Thomas, Radimerski, Thomas, Thoma, Claudio, Hebach, Christina, Tschantz, William R., Karpov, Alexei, Hollingworth, Gregory J., D’Alessio, Joseph A., Ferretti, Stephane, Burger, Matthew T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agammaglobulinaemia Tyrosine Kinase Antibodies, Monoclonal - chemistry Binding Biocompatibility Biodegradation Bruton's tyrosine kinase Conjugates Cytotoxicity Degradation Immunoconjugates - chemistry Kinases Monoclonal antibodies Tyrosine
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