Aging, Neurodegenerative Disorders, and Cerebellum
An important part of the central nervous system (CNS), the cerebellum is involved in motor control, learning, reflex adaptation, and cognition. Diminished cerebellar function results in the motor and cognitive impairment observed in patients with neurodegenerative disorders such as Alzheimer's...
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| Veröffentlicht in: | International journal of molecular sciences 2024-01, Vol.25 (2), p.1018 |
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| creator | Iskusnykh, Igor Y Zakharova, Anastasia A Kryl'skii, Evgenii D Popova, Tatyana N |
| description | An important part of the central nervous system (CNS), the cerebellum is involved in motor control, learning, reflex adaptation, and cognition. Diminished cerebellar function results in the motor and cognitive impairment observed in patients with neurodegenerative disorders such as Alzheimer's disease (AD), vascular dementia (VD), Parkinson's disease (PD), Huntington's disease (HD), spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), Friedreich's ataxia (FRDA), and multiple sclerosis (MS), and even during the normal aging process. In most neurodegenerative disorders, impairment mainly occurs as a result of morphological changes over time, although during the early stages of some disorders such as AD, the cerebellum also serves a compensatory function. Biological aging is accompanied by changes in cerebellar circuits, which are predominantly involved in motor control. Despite decades of research, the functional contributions of the cerebellum and the underlying molecular mechanisms in aging and neurodegenerative disorders remain largely unknown. Therefore, this review will highlight the molecular and cellular events in the cerebellum that are disrupted during the process of aging and the development of neurodegenerative disorders. We believe that deeper insights into the pathophysiological mechanisms of the cerebellum during aging and the development of neurodegenerative disorders will be essential for the design of new effective strategies for neuroprotection and the alleviation of some neurodegenerative disorders. |
| doi_str_mv | 10.3390/ijms25021018 |
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Diminished cerebellar function results in the motor and cognitive impairment observed in patients with neurodegenerative disorders such as Alzheimer's disease (AD), vascular dementia (VD), Parkinson's disease (PD), Huntington's disease (HD), spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), Friedreich's ataxia (FRDA), and multiple sclerosis (MS), and even during the normal aging process. In most neurodegenerative disorders, impairment mainly occurs as a result of morphological changes over time, although during the early stages of some disorders such as AD, the cerebellum also serves a compensatory function. Biological aging is accompanied by changes in cerebellar circuits, which are predominantly involved in motor control. Despite decades of research, the functional contributions of the cerebellum and the underlying molecular mechanisms in aging and neurodegenerative disorders remain largely unknown. Therefore, this review will highlight the molecular and cellular events in the cerebellum that are disrupted during the process of aging and the development of neurodegenerative disorders. We believe that deeper insights into the pathophysiological mechanisms of the cerebellum during aging and the development of neurodegenerative disorders will be essential for the design of new effective strategies for neuroprotection and the alleviation of some neurodegenerative disorders.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms25021018</identifier><identifier>PMID: 38256091</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Advertising executives ; Age ; Aging ; Alzheimer Disease ; Alzheimer's disease ; Amyotrophic lateral sclerosis ; Ataxia ; Brain ; Cerebellum ; Cognition & reasoning ; Cognitive ability ; Cytochrome ; Dehydrogenases ; Development and progression ; Humans ; Huntington Disease ; Huntingtons disease ; Metabolism ; Mitochondria ; Multiple sclerosis ; Nervous system diseases ; Neurodegeneration ; Neurodegenerative Diseases ; Proteins</subject><ispartof>International journal of molecular sciences, 2024-01, Vol.25 (2), p.1018</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| subjects | Advertising executives Age Aging Alzheimer Disease Alzheimer's disease Amyotrophic lateral sclerosis Ataxia Brain Cerebellum Cognition & reasoning Cognitive ability Cytochrome Dehydrogenases Development and progression Humans Huntington Disease Huntingtons disease Metabolism Mitochondria Multiple sclerosis Nervous system diseases Neurodegeneration Neurodegenerative Diseases Proteins |
| title | Aging, Neurodegenerative Disorders, and Cerebellum |
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