From Synaptic Physiology to Synaptic Pathology: The Enigma of α-Synuclein
Alpha-synuclein (α-syn) has gained significant attention due to its involvement in neurodegenerative diseases, particularly Parkinson's disease. However, its normal function in the human brain is equally fascinating. The α-syn protein is highly dynamic and can adapt to various conformational st...
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| Veröffentlicht in: | International journal of molecular sciences 2024-01, Vol.25 (2), p.986 |
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| description | Alpha-synuclein (α-syn) has gained significant attention due to its involvement in neurodegenerative diseases, particularly Parkinson's disease. However, its normal function in the human brain is equally fascinating. The α-syn protein is highly dynamic and can adapt to various conformational stages, which differ in their interaction with synaptic elements, their propensity to drive pathological aggregation, and their toxicity. This review will delve into the multifaceted role of α-syn in different types of synapses, shedding light on contributions to neurotransmission and overall brain function. We describe the physiological role of α-syn at central synapses, including the bidirectional interaction between α-syn and neurotransmitter systems. |
| doi_str_mv | 10.3390/ijms25020986 |
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| subjects | Aggregates alpha-Synuclein Amino acids Biomarkers Brain Development and progression Disease Humans Nervous system diseases Neurodegeneration Parkinson Disease Physiological aspects Proteins Synapses Synaptic Transmission Toxicity |
| title | From Synaptic Physiology to Synaptic Pathology: The Enigma of α-Synuclein |
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