Tattoo-Associated Skin Reaction in a Melanoma Patient Receiving B-RAF and MEK Inhibitors: A Case Report with an Emphasis on Etiopathogenic and Histological Features
Tattoo-associated cutaneous reactions have become quite frequent given the increasing percentage of tattooed subjects globally and also in Italy. On the other hand, the increasing use of target therapy is showing the ability of these drugs to affect the immune system and also cause adverse tattoo-re...
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| Veröffentlicht in: | Journal of clinical medicine 2024-01, Vol.13 (2), p.321 |
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| creator | Baratta, Silvia Cazzato, Gerardo Foti, Caterina Ingravallo, Giuseppe Lospalluti, Lucia Laface, Carmelo Filotico, Raffaele Ambrogio, Francesca |
| description | Tattoo-associated cutaneous reactions have become quite frequent given the increasing percentage of tattooed subjects globally and also in Italy. On the other hand, the increasing use of target therapy is showing the ability of these drugs to affect the immune system and also cause adverse tattoo-related reactions. In this paper, we report a case of a 42-year-old patient with stage-IIID melanoma undergoing treatment with Dabrafenib and Trametinib. The patient reported erythema, oedema and scaling in areas of the body containing a black tattoo, and, conversely, no signs and/or symptoms in areas with tattoos of a different color. Histopathological and immunohistochemical features indicated a lympho-histiocytic reaction with a granulomatous morphology, mainly distributed around the vessels and hair adnexa. By discussing the cases reported in the literature prior to ours, we concluded and provided the possible indications of the pathogenesis. |
| doi_str_mv | 10.3390/jcm13020321 |
| format | Article |
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On the other hand, the increasing use of target therapy is showing the ability of these drugs to affect the immune system and also cause adverse tattoo-related reactions. In this paper, we report a case of a 42-year-old patient with stage-IIID melanoma undergoing treatment with Dabrafenib and Trametinib. The patient reported erythema, oedema and scaling in areas of the body containing a black tattoo, and, conversely, no signs and/or symptoms in areas with tattoos of a different color. Histopathological and immunohistochemical features indicated a lympho-histiocytic reaction with a granulomatous morphology, mainly distributed around the vessels and hair adnexa. By discussing the cases reported in the literature prior to ours, we concluded and provided the possible indications of the pathogenesis.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13020321</identifier><identifier>PMID: 38256455</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antimitotic agents ; Antineoplastic agents ; Biopsy ; Care and treatment ; Case reports ; Diagnosis ; Dosage and administration ; Edema ; Erythema ; Health aspects ; Lymphocytes ; Lymphoma ; Melanoma ; Patients ; Pigments ; Risk factors ; Sarcoidosis ; Skin ; Tattooing ; Tattoos</subject><ispartof>Journal of clinical medicine, 2024-01, Vol.13 (2), p.321</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. 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| subjects | Antimitotic agents Antineoplastic agents Biopsy Care and treatment Case reports Diagnosis Dosage and administration Edema Erythema Health aspects Lymphocytes Lymphoma Melanoma Patients Pigments Risk factors Sarcoidosis Skin Tattooing Tattoos |
| title | Tattoo-Associated Skin Reaction in a Melanoma Patient Receiving B-RAF and MEK Inhibitors: A Case Report with an Emphasis on Etiopathogenic and Histological Features |
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