The Ultrasound Renal Stress Test for the Assessment of Functional Renal Reserve in Kidney Transplantation: A Pilot Study in Living Donors
In the evolving landscape of nephrology and kidney transplants, assessing renal functional reserve (RFR) in living kidney donors is essential for ensuring donor safety and successful transplantation. This study explores the use of the Intra-Parenchymal Renal Resistive Index Variation (IRRIV) test, a...
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| Veröffentlicht in: | Journal of clinical medicine 2024-01, Vol.13 (2), p.525 |
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| creator | Nalesso, Federico Martino, Francesca K Bogo, Marco Bettin, Elisabetta Alessi, Marianna Stefanelli, Lucia F Silvestre, Cristina Furian, Lucrezia Calò, Lorenzo A |
| description | In the evolving landscape of nephrology and kidney transplants, assessing renal functional reserve (RFR) in living kidney donors is essential for ensuring donor safety and successful transplantation. This study explores the use of the Intra-Parenchymal Renal Resistive Index Variation (IRRIV) test, a novel non-invasive method, to measure RFR in living donors. Our observational study included 11 participants undergoing living kidney donations, evaluated using the IRRIV-based Renal Stress Test (RST) before and 12 months post-nephrectomy. The study demonstrated significant changes in creatinine and eGFR CKD-EPI levels post-donation, with an average creatinine rise from 69 to 97 µmol/L and a reduction in eGFR from 104 to 66 mL/min/1.73 m
. These variations align with the expected halving of nephron mass post-nephrectomy and the consequent recruitment of RFR and hyperfiltration in the remaining nephrons. This pilot study suggests that the IRRIV-based RST is a practical, safe, and reproducible tool, potentially revolutionizing the assessment of RFR in living kidney donors, with implications for broader clinical practice in donor eligibility evaluation, even in borderline renal cases. Furthermore, it confirms the feasibility of RST in living kidney donors and allows us to assess the sample size in 48 donors for a future study. |
| doi_str_mv | 10.3390/jcm13020525 |
| format | Article |
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. These variations align with the expected halving of nephron mass post-nephrectomy and the consequent recruitment of RFR and hyperfiltration in the remaining nephrons. This pilot study suggests that the IRRIV-based RST is a practical, safe, and reproducible tool, potentially revolutionizing the assessment of RFR in living kidney donors, with implications for broader clinical practice in donor eligibility evaluation, even in borderline renal cases. Furthermore, it confirms the feasibility of RST in living kidney donors and allows us to assess the sample size in 48 donors for a future study.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13020525</identifier><identifier>PMID: 38256658</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Abdomen ; Analysis ; Creatinine ; Donation of organs, tissues, etc ; Heart surgery ; Kidney transplants ; Kidneys ; Medical tests ; Patients ; Pilot projects ; Proteins ; Transplantation ; Ultrasonic imaging</subject><ispartof>Journal of clinical medicine, 2024-01, Vol.13 (2), p.525</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c379t-aa9b665b3f6214cf9f058516a52663f35df2b2d516def3ed2d4c92911247d28b3</cites><orcidid>0000-0002-1167-2764 ; 0000-0002-2402-9276 ; 0000-0002-7534-0128</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38256658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nalesso, Federico</creatorcontrib><creatorcontrib>Martino, Francesca K</creatorcontrib><creatorcontrib>Bogo, Marco</creatorcontrib><creatorcontrib>Bettin, Elisabetta</creatorcontrib><creatorcontrib>Alessi, Marianna</creatorcontrib><creatorcontrib>Stefanelli, Lucia F</creatorcontrib><creatorcontrib>Silvestre, Cristina</creatorcontrib><creatorcontrib>Furian, Lucrezia</creatorcontrib><creatorcontrib>Calò, Lorenzo A</creatorcontrib><title>The Ultrasound Renal Stress Test for the Assessment of Functional Renal Reserve in Kidney Transplantation: A Pilot Study in Living Donors</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>In the evolving landscape of nephrology and kidney transplants, assessing renal functional reserve (RFR) in living kidney donors is essential for ensuring donor safety and successful transplantation. This study explores the use of the Intra-Parenchymal Renal Resistive Index Variation (IRRIV) test, a novel non-invasive method, to measure RFR in living donors. Our observational study included 11 participants undergoing living kidney donations, evaluated using the IRRIV-based Renal Stress Test (RST) before and 12 months post-nephrectomy. The study demonstrated significant changes in creatinine and eGFR CKD-EPI levels post-donation, with an average creatinine rise from 69 to 97 µmol/L and a reduction in eGFR from 104 to 66 mL/min/1.73 m
. These variations align with the expected halving of nephron mass post-nephrectomy and the consequent recruitment of RFR and hyperfiltration in the remaining nephrons. This pilot study suggests that the IRRIV-based RST is a practical, safe, and reproducible tool, potentially revolutionizing the assessment of RFR in living kidney donors, with implications for broader clinical practice in donor eligibility evaluation, even in borderline renal cases. Furthermore, it confirms the feasibility of RST in living kidney donors and allows us to assess the sample size in 48 donors for a future study.</description><subject>Abdomen</subject><subject>Analysis</subject><subject>Creatinine</subject><subject>Donation of organs, tissues, etc</subject><subject>Heart surgery</subject><subject>Kidney transplants</subject><subject>Kidneys</subject><subject>Medical tests</subject><subject>Patients</subject><subject>Pilot projects</subject><subject>Proteins</subject><subject>Transplantation</subject><subject>Ultrasonic imaging</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpt0U9rFDEUAPBBLLbUnrxLwIsgW_NnMsl4W6qt4kKlbs9DJnmpWWaSNckU9iP4rZtxq7bS5JDw-L3HS15VvSL4lLEWv9_okTBMMaf8WXVEsRALzCR7_uB-WJ2ktMFlSVlTIl5Uh0xS3jRcHlW_1j8AXQ85qhQmb9AVeDWg7zlCSmgNKSMbIsoFLVMqsRF8RsGi88nr7MKM9ylXkCDeAnIefXXGww6to_JpOyif1Sw_oCX65oaQS_XJ7Ga4crfO36CPwYeYXlYHVg0JTu7P4-r6_NP67PNidXnx5Wy5Wmgm2rxQqu1L6z2zDSW1tq3FXHLSKE6bhlnGjaU9NSViwDIw1NS6pS0htBaGyp4dV2_3dbcx_JzKC7vRJQ1DaRTClLpihWwEJ6TQN__RTZhiee1vJYVgTLb_1I0aoHPehvKbei7aLYXEM6vrok6fUGUbGJ0OHqwr8UcJ7_YJOoaUIthuG92o4q4juJtn3z2YfdGv71ud-hHMX_tn0uwOMy-n-g</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Nalesso, Federico</creator><creator>Martino, Francesca K</creator><creator>Bogo, Marco</creator><creator>Bettin, Elisabetta</creator><creator>Alessi, Marianna</creator><creator>Stefanelli, Lucia F</creator><creator>Silvestre, Cristina</creator><creator>Furian, Lucrezia</creator><creator>Calò, Lorenzo A</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1167-2764</orcidid><orcidid>https://orcid.org/0000-0002-2402-9276</orcidid><orcidid>https://orcid.org/0000-0002-7534-0128</orcidid></search><sort><creationdate>20240101</creationdate><title>The Ultrasound Renal Stress Test for the Assessment of Functional Renal Reserve in Kidney Transplantation: A Pilot Study in Living Donors</title><author>Nalesso, Federico ; 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| subjects | Abdomen Analysis Creatinine Donation of organs, tissues, etc Heart surgery Kidney transplants Kidneys Medical tests Patients Pilot projects Proteins Transplantation Ultrasonic imaging |
| title | The Ultrasound Renal Stress Test for the Assessment of Functional Renal Reserve in Kidney Transplantation: A Pilot Study in Living Donors |
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