The Heart's Function as a Pump Assessed via Impedance Cardiography and the Autonomic System Balance in Patients with Early-Stage Acromegaly
Acromegaly is a rare, chronic disease that involves structural and functional abnormalities of the cardiovascular system. Acromegaly likely affects interactions between the cardiovascular system and the autonomic nervous system (ANS). Therefore, assessing the relationship between sympathetic-parasym...
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| Veröffentlicht in: | Journal of clinical medicine 2024-01, Vol.13 (2), p.395 |
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| creator | Jurek, Agnieszka Krzesiński, Paweł Wierzbowski, Robert Uziębło-Życzkowska, Beata Witek, Przemysław Zieliński, Grzegorz Kazimierczak, Anna Banak, Małgorzata Gielerak, Grzegorz |
| description | Acromegaly is a rare, chronic disease that involves structural and functional abnormalities of the cardiovascular system. Acromegaly likely affects interactions between the cardiovascular system and the autonomic nervous system (ANS). Therefore, assessing the relationship between sympathetic-parasympathetic balance by analyzing heart rate variability (HRV) and the hemodynamic profile via impedance cardiography (ICG) may be useful in learning the exact nature of interactions between the ANS and the cardiovascular system. The purpose of this study was to assess a possible association between HRV and ICG-based parameters of cardiac function in patients newly diagnosed with acromegaly.
This observational cohort study was conducted on 33 patients (18 men, mean age of 47 years) newly diagnosed with acromegaly and no significant comorbidities. A correlation analysis (Spearman's rank coefficient R) of the parameters assessed via ICG and the HRV assessed via 24 h ambulatory electrocardiography was performed. ICG assessments included the following parameters: stroke volume index (SI), cardiac index (CI), acceleration index (ACI), velocity index (VI), and Heather index (HI). The analysis of HRV included both time-domain parameters (pNN50, SDNN, SDSD, rMSSD) and frequency-domain parameters (total power (TP) and its individual frequency bands: low-frequency (LF day/night), high-frequency (HF day/night), and the LF/HF ratio (day/night)).
Frequency-domain HRV analysis showed the following correlations: (1) lower nighttime LF values with higher ACI (R = -0.38;
= 0.027) and HI (R = -0.46;
= 0.007) values; (2) higher nighttime HF values with higher ACI (R = 0.39;
= 0.027) and HI (R = 0.43;
= 0.014) values; (3) lower nighttime LF/HF values with higher ACI (R = -0.36;
= 0.037) and HI (R = -0.42;
= 0.014) values; (4) higher nighttime TP values with higher SI values (R = 0.35;
= 0.049). Time-domain parameters of HRV showed a significant correlation only between the nighttime values of SDSD and SI (R = 0.35;
= 0.049) and between the daytime and nighttime values of SDNN and HR (R = -0.50;
= 0.003 and R = -0.35;
= 0.046). In multivariate regression, only ACI was revealed to be independently related to HRV.
In patients newly diagnosed with acromegaly, the relationship between the sympathetic-parasympathetic balance assessed via HRV and the hemodynamic profile assessed via ICG was revealed. Better function of the left ventricle was associated with a parasympathetic shift in the auto |
| doi_str_mv | 10.3390/jcm13020395 |
| format | Article |
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This observational cohort study was conducted on 33 patients (18 men, mean age of 47 years) newly diagnosed with acromegaly and no significant comorbidities. A correlation analysis (Spearman's rank coefficient R) of the parameters assessed via ICG and the HRV assessed via 24 h ambulatory electrocardiography was performed. ICG assessments included the following parameters: stroke volume index (SI), cardiac index (CI), acceleration index (ACI), velocity index (VI), and Heather index (HI). The analysis of HRV included both time-domain parameters (pNN50, SDNN, SDSD, rMSSD) and frequency-domain parameters (total power (TP) and its individual frequency bands: low-frequency (LF day/night), high-frequency (HF day/night), and the LF/HF ratio (day/night)).
Frequency-domain HRV analysis showed the following correlations: (1) lower nighttime LF values with higher ACI (R = -0.38;
= 0.027) and HI (R = -0.46;
= 0.007) values; (2) higher nighttime HF values with higher ACI (R = 0.39;
= 0.027) and HI (R = 0.43;
= 0.014) values; (3) lower nighttime LF/HF values with higher ACI (R = -0.36;
= 0.037) and HI (R = -0.42;
= 0.014) values; (4) higher nighttime TP values with higher SI values (R = 0.35;
= 0.049). Time-domain parameters of HRV showed a significant correlation only between the nighttime values of SDSD and SI (R = 0.35;
= 0.049) and between the daytime and nighttime values of SDNN and HR (R = -0.50;
= 0.003 and R = -0.35;
= 0.046). In multivariate regression, only ACI was revealed to be independently related to HRV.
In patients newly diagnosed with acromegaly, the relationship between the sympathetic-parasympathetic balance assessed via HRV and the hemodynamic profile assessed via ICG was revealed. Better function of the left ventricle was associated with a parasympathetic shift in the autonomic balance.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13020395</identifier><identifier>PMID: 38256528</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acromegaly ; Blood pressure ; Cardiac arrhythmia ; Cardiography ; Cardiovascular disease ; Care and treatment ; Diagnosis ; Electrocardiography ; Evaluation ; Glucose ; Heart failure ; Heart rate ; Hemodynamics ; Insulin-like growth factors ; Metabolism ; Mortality ; Nervous system ; Patients</subject><ispartof>Journal of clinical medicine, 2024-01, Vol.13 (2), p.395</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c379t-27f53c6b1cfdfd0d1f35f17117cb410e51107ecd1084d53f0f2196ed81b56c53</cites><orcidid>0000-0001-6881-7525 ; 0000-0001-8997-6568 ; 0000-0003-1909-0993</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38256528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jurek, Agnieszka</creatorcontrib><creatorcontrib>Krzesiński, Paweł</creatorcontrib><creatorcontrib>Wierzbowski, Robert</creatorcontrib><creatorcontrib>Uziębło-Życzkowska, Beata</creatorcontrib><creatorcontrib>Witek, Przemysław</creatorcontrib><creatorcontrib>Zieliński, Grzegorz</creatorcontrib><creatorcontrib>Kazimierczak, Anna</creatorcontrib><creatorcontrib>Banak, Małgorzata</creatorcontrib><creatorcontrib>Gielerak, Grzegorz</creatorcontrib><title>The Heart's Function as a Pump Assessed via Impedance Cardiography and the Autonomic System Balance in Patients with Early-Stage Acromegaly</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Acromegaly is a rare, chronic disease that involves structural and functional abnormalities of the cardiovascular system. Acromegaly likely affects interactions between the cardiovascular system and the autonomic nervous system (ANS). Therefore, assessing the relationship between sympathetic-parasympathetic balance by analyzing heart rate variability (HRV) and the hemodynamic profile via impedance cardiography (ICG) may be useful in learning the exact nature of interactions between the ANS and the cardiovascular system. The purpose of this study was to assess a possible association between HRV and ICG-based parameters of cardiac function in patients newly diagnosed with acromegaly.
This observational cohort study was conducted on 33 patients (18 men, mean age of 47 years) newly diagnosed with acromegaly and no significant comorbidities. A correlation analysis (Spearman's rank coefficient R) of the parameters assessed via ICG and the HRV assessed via 24 h ambulatory electrocardiography was performed. ICG assessments included the following parameters: stroke volume index (SI), cardiac index (CI), acceleration index (ACI), velocity index (VI), and Heather index (HI). The analysis of HRV included both time-domain parameters (pNN50, SDNN, SDSD, rMSSD) and frequency-domain parameters (total power (TP) and its individual frequency bands: low-frequency (LF day/night), high-frequency (HF day/night), and the LF/HF ratio (day/night)).
Frequency-domain HRV analysis showed the following correlations: (1) lower nighttime LF values with higher ACI (R = -0.38;
= 0.027) and HI (R = -0.46;
= 0.007) values; (2) higher nighttime HF values with higher ACI (R = 0.39;
= 0.027) and HI (R = 0.43;
= 0.014) values; (3) lower nighttime LF/HF values with higher ACI (R = -0.36;
= 0.037) and HI (R = -0.42;
= 0.014) values; (4) higher nighttime TP values with higher SI values (R = 0.35;
= 0.049). Time-domain parameters of HRV showed a significant correlation only between the nighttime values of SDSD and SI (R = 0.35;
= 0.049) and between the daytime and nighttime values of SDNN and HR (R = -0.50;
= 0.003 and R = -0.35;
= 0.046). In multivariate regression, only ACI was revealed to be independently related to HRV.
In patients newly diagnosed with acromegaly, the relationship between the sympathetic-parasympathetic balance assessed via HRV and the hemodynamic profile assessed via ICG was revealed. Better function of the left ventricle was associated with a parasympathetic shift in the autonomic balance.</description><subject>Acromegaly</subject><subject>Blood pressure</subject><subject>Cardiac arrhythmia</subject><subject>Cardiography</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Diagnosis</subject><subject>Electrocardiography</subject><subject>Evaluation</subject><subject>Glucose</subject><subject>Heart failure</subject><subject>Heart rate</subject><subject>Hemodynamics</subject><subject>Insulin-like growth factors</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Nervous system</subject><subject>Patients</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkV9LHDEUxYfSUsX61PcS6EMLMjZ_ZiaZx3XRKggV3Pchm9zsZplJpklGmc_QL222arWlSeCG8DuHm3uK4iPBp4y1-NtODYRhillbvykOKea8xEywt6_uB8VxjDuclxAVJfx9ccAErZuaisPi12oL6BJkSF8iupicStY7JCOS6GYaRrSIEfLR6M5KdDWMoKVTgJYyaOs3QY7bGUmnUco2iyl55wer0O0cEwzoTPa_aevQjUwWXIro3qYtOpehn8vbJDdZpYIfYCP7-UPxzsg-wvFTPSpWF-er5WV5_eP71XJxXSrG21RSbmqmmjVRRhuNNTGsNoQTwtW6IhhqQjAHpQkWla6ZwYaStgEtyLpuVM2Oiq-PtmPwPyeIqRtsVNDnXsFPsaMt4aLhpK0y-vkfdOen4HJze0pwzipCX6j8CeisMz4Fqfam3YILnDFK9l6n_6Hy1pBH5h0Ym9__Epw8CvKAYgxgujHYQYa5I7jbh9-9Cj_Tn55andYD6D_sc9TsAUEtqA4</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Jurek, Agnieszka</creator><creator>Krzesiński, Paweł</creator><creator>Wierzbowski, Robert</creator><creator>Uziębło-Życzkowska, Beata</creator><creator>Witek, Przemysław</creator><creator>Zieliński, Grzegorz</creator><creator>Kazimierczak, Anna</creator><creator>Banak, Małgorzata</creator><creator>Gielerak, Grzegorz</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6881-7525</orcidid><orcidid>https://orcid.org/0000-0001-8997-6568</orcidid><orcidid>https://orcid.org/0000-0003-1909-0993</orcidid></search><sort><creationdate>20240101</creationdate><title>The Heart's Function as a Pump Assessed via Impedance Cardiography and the Autonomic System Balance in Patients with Early-Stage Acromegaly</title><author>Jurek, Agnieszka ; Krzesiński, Paweł ; Wierzbowski, Robert ; Uziębło-Życzkowska, Beata ; Witek, Przemysław ; Zieliński, Grzegorz ; Kazimierczak, Anna ; Banak, Małgorzata ; Gielerak, Grzegorz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-27f53c6b1cfdfd0d1f35f17117cb410e51107ecd1084d53f0f2196ed81b56c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acromegaly</topic><topic>Blood pressure</topic><topic>Cardiac arrhythmia</topic><topic>Cardiography</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Diagnosis</topic><topic>Electrocardiography</topic><topic>Evaluation</topic><topic>Glucose</topic><topic>Heart failure</topic><topic>Heart rate</topic><topic>Hemodynamics</topic><topic>Insulin-like growth factors</topic><topic>Metabolism</topic><topic>Mortality</topic><topic>Nervous system</topic><topic>Patients</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jurek, Agnieszka</creatorcontrib><creatorcontrib>Krzesiński, Paweł</creatorcontrib><creatorcontrib>Wierzbowski, Robert</creatorcontrib><creatorcontrib>Uziębło-Życzkowska, Beata</creatorcontrib><creatorcontrib>Witek, Przemysław</creatorcontrib><creatorcontrib>Zieliński, Grzegorz</creatorcontrib><creatorcontrib>Kazimierczak, Anna</creatorcontrib><creatorcontrib>Banak, Małgorzata</creatorcontrib><creatorcontrib>Gielerak, Grzegorz</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jurek, Agnieszka</au><au>Krzesiński, Paweł</au><au>Wierzbowski, Robert</au><au>Uziębło-Życzkowska, Beata</au><au>Witek, Przemysław</au><au>Zieliński, Grzegorz</au><au>Kazimierczak, Anna</au><au>Banak, Małgorzata</au><au>Gielerak, Grzegorz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Heart's Function as a Pump Assessed via Impedance Cardiography and the Autonomic System Balance in Patients with Early-Stage Acromegaly</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>13</volume><issue>2</issue><spage>395</spage><pages>395-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Acromegaly is a rare, chronic disease that involves structural and functional abnormalities of the cardiovascular system. Acromegaly likely affects interactions between the cardiovascular system and the autonomic nervous system (ANS). Therefore, assessing the relationship between sympathetic-parasympathetic balance by analyzing heart rate variability (HRV) and the hemodynamic profile via impedance cardiography (ICG) may be useful in learning the exact nature of interactions between the ANS and the cardiovascular system. The purpose of this study was to assess a possible association between HRV and ICG-based parameters of cardiac function in patients newly diagnosed with acromegaly.
This observational cohort study was conducted on 33 patients (18 men, mean age of 47 years) newly diagnosed with acromegaly and no significant comorbidities. A correlation analysis (Spearman's rank coefficient R) of the parameters assessed via ICG and the HRV assessed via 24 h ambulatory electrocardiography was performed. ICG assessments included the following parameters: stroke volume index (SI), cardiac index (CI), acceleration index (ACI), velocity index (VI), and Heather index (HI). The analysis of HRV included both time-domain parameters (pNN50, SDNN, SDSD, rMSSD) and frequency-domain parameters (total power (TP) and its individual frequency bands: low-frequency (LF day/night), high-frequency (HF day/night), and the LF/HF ratio (day/night)).
Frequency-domain HRV analysis showed the following correlations: (1) lower nighttime LF values with higher ACI (R = -0.38;
= 0.027) and HI (R = -0.46;
= 0.007) values; (2) higher nighttime HF values with higher ACI (R = 0.39;
= 0.027) and HI (R = 0.43;
= 0.014) values; (3) lower nighttime LF/HF values with higher ACI (R = -0.36;
= 0.037) and HI (R = -0.42;
= 0.014) values; (4) higher nighttime TP values with higher SI values (R = 0.35;
= 0.049). Time-domain parameters of HRV showed a significant correlation only between the nighttime values of SDSD and SI (R = 0.35;
= 0.049) and between the daytime and nighttime values of SDNN and HR (R = -0.50;
= 0.003 and R = -0.35;
= 0.046). In multivariate regression, only ACI was revealed to be independently related to HRV.
In patients newly diagnosed with acromegaly, the relationship between the sympathetic-parasympathetic balance assessed via HRV and the hemodynamic profile assessed via ICG was revealed. Better function of the left ventricle was associated with a parasympathetic shift in the autonomic balance.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38256528</pmid><doi>10.3390/jcm13020395</doi><orcidid>https://orcid.org/0000-0001-6881-7525</orcidid><orcidid>https://orcid.org/0000-0001-8997-6568</orcidid><orcidid>https://orcid.org/0000-0003-1909-0993</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of clinical medicine, 2024-01, Vol.13 (2), p.395 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Acromegaly Blood pressure Cardiac arrhythmia Cardiography Cardiovascular disease Care and treatment Diagnosis Electrocardiography Evaluation Glucose Heart failure Heart rate Hemodynamics Insulin-like growth factors Metabolism Mortality Nervous system Patients |
| title | The Heart's Function as a Pump Assessed via Impedance Cardiography and the Autonomic System Balance in Patients with Early-Stage Acromegaly |
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