Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins

The suppressor of T cell receptor signaling (Sts) proteins are negative regulators of immune signaling. Genetic inactivation of these proteins leads to significant resistance to infection. From a 590,000 compound high-throughput screen, we identified the 2-(1H)-quinolinone derivative, rebamipide, as...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-02, Vol.67 (3), p.1949-1960
Hauptverfasser:	Aziz, Faisal, Reddy, Kanamata, Fernandez Vega, Virneliz, Dey, Raja, Hicks, Katherine A., Rao, Sumitha, Jordan, Luis Ortiz, Smith, Emery, Shumate, Justin, Scampavia, Louis, Carpino, Nicholas, Spicer, Timothy P., French, Jarrod B.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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