The role of hyperleptinaemia and low values of interleukin 10 in de novo DSA production after kidney transplantation
White adipose tissue secretes a number of peptide hormones. The aim of this paper was to determine the role of leptin, adiponectin and interleukin-10 and interleukin-6 on the development of graft rejection in protocol biopsy after kidney transplantation. In a prospective analysis (n = 104), we monit...
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| Veröffentlicht in: | Transplant immunology 2024-04, Vol.83, p.101982-101982, Article 101982 |
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| container_title | Transplant immunology |
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| creator | Dedinská, Ivana Kleinová, Patrícia Macháleková, Katarína Graňák, Karol Vnučák, Matej Beliančinová, Monika |
| description | White adipose tissue secretes a number of peptide hormones. The aim of this paper was to determine the role of leptin, adiponectin and interleukin-10 and interleukin-6 on the development of graft rejection in protocol biopsy after kidney transplantation.
In a prospective analysis (n = 104), we monitored the values of leptin, adiponectin, IL-6, and IL-10 prior to the transplantation and in the 3rd month after the transplantation. The protocol biopsy of the graft was performed in the 3rd month after the transplantation. The group was divided into the following according to the biopsy result: negative result, IFTA 1, borderline, and DSA positive.
After adjusting for the differences in the baseline recipient and donor characteristics, we identified the hyperleptinaemia baseline (HR = 2.0444, P = 0.0341) and month 3 (HR = 49.8043, P |
| doi_str_mv | 10.1016/j.trim.2023.101982 |
| format | Article |
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In a prospective analysis (n = 104), we monitored the values of leptin, adiponectin, IL-6, and IL-10 prior to the transplantation and in the 3rd month after the transplantation. The protocol biopsy of the graft was performed in the 3rd month after the transplantation. The group was divided into the following according to the biopsy result: negative result, IFTA 1, borderline, and DSA positive.
After adjusting for the differences in the baseline recipient and donor characteristics, we identified the hyperleptinaemia baseline (HR = 2.0444, P = 0.0341) and month 3 (HR = 49.8043, P < 0.0001) as independent risk factors for borderline changes in the protocol biopsy. The hyperleptinaemia baseline (HR = 7.4979, P = 0.0071) and month 3 (HR = 9.7432, P = 0.0057) are independent risk factors for de novo DSA positivity. A low value of IL-10 month 3 is a risk factor for de novo DSA positivity (HR = 3.0746, P = 0.0388).
Higher leptin levels and low values of IL-10 might play a role in rejection and de novo DSA production.
•The hyperleptinaemia baseline and month 3 as independent risk factors for borderline changes in protocol biopsies.•The hyperleptinaemia baseline and month 3 as independent risk factors for de novo donor specific antibodies production.•Hypo-IL-10 as an independent risk factor for donor specific antibodies positivity in the 3rd month after transplantation.</description><identifier>ISSN: 0966-3274</identifier><identifier>EISSN: 1878-5492</identifier><identifier>DOI: 10.1016/j.trim.2023.101982</identifier><identifier>PMID: 38218229</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adiponectin ; Graft Rejection - etiology ; Graft Survival ; IL-10 ; Interleukin-10 ; Isoantibodies ; Kidney transplantation ; Kidney Transplantation - adverse effects ; Leptin ; Protocol biopsy ; Retrospective Studies ; Tissue Donors</subject><ispartof>Transplant immunology, 2024-04, Vol.83, p.101982-101982, Article 101982</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c351t-39df9e5d1a4f6ae4acb6935f5f8cbea0acd7b15d97c363a382ede55b7972186b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0966327423001995$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38218229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dedinská, Ivana</creatorcontrib><creatorcontrib>Kleinová, Patrícia</creatorcontrib><creatorcontrib>Macháleková, Katarína</creatorcontrib><creatorcontrib>Graňák, Karol</creatorcontrib><creatorcontrib>Vnučák, Matej</creatorcontrib><creatorcontrib>Beliančinová, Monika</creatorcontrib><title>The role of hyperleptinaemia and low values of interleukin 10 in de novo DSA production after kidney transplantation</title><title>Transplant immunology</title><addtitle>Transpl Immunol</addtitle><description>White adipose tissue secretes a number of peptide hormones. The aim of this paper was to determine the role of leptin, adiponectin and interleukin-10 and interleukin-6 on the development of graft rejection in protocol biopsy after kidney transplantation.
In a prospective analysis (n = 104), we monitored the values of leptin, adiponectin, IL-6, and IL-10 prior to the transplantation and in the 3rd month after the transplantation. The protocol biopsy of the graft was performed in the 3rd month after the transplantation. The group was divided into the following according to the biopsy result: negative result, IFTA 1, borderline, and DSA positive.
After adjusting for the differences in the baseline recipient and donor characteristics, we identified the hyperleptinaemia baseline (HR = 2.0444, P = 0.0341) and month 3 (HR = 49.8043, P < 0.0001) as independent risk factors for borderline changes in the protocol biopsy. The hyperleptinaemia baseline (HR = 7.4979, P = 0.0071) and month 3 (HR = 9.7432, P = 0.0057) are independent risk factors for de novo DSA positivity. A low value of IL-10 month 3 is a risk factor for de novo DSA positivity (HR = 3.0746, P = 0.0388).
Higher leptin levels and low values of IL-10 might play a role in rejection and de novo DSA production.
•The hyperleptinaemia baseline and month 3 as independent risk factors for borderline changes in protocol biopsies.•The hyperleptinaemia baseline and month 3 as independent risk factors for de novo donor specific antibodies production.•Hypo-IL-10 as an independent risk factor for donor specific antibodies positivity in the 3rd month after transplantation.</description><subject>Adiponectin</subject><subject>Graft Rejection - etiology</subject><subject>Graft Survival</subject><subject>IL-10</subject><subject>Interleukin-10</subject><subject>Isoantibodies</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Leptin</subject><subject>Protocol biopsy</subject><subject>Retrospective Studies</subject><subject>Tissue Donors</subject><issn>0966-3274</issn><issn>1878-5492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u3CAURlGVqpmkfYEuIpbZeMqPsY2UTZS0TaVIXTRdIwzXGmY84ACeat6-WJNkmRUCzv10v4PQV0rWlNDm23ado9uvGWF8eZAd-4BWtGu7StSSnaEVkU1TcdbW5-gipS0hhAnZfkLnvGO0Y0yuUH7aAI5hBBwGvDlOEEeYsvMa9k5j7S0ewz980OMMaUGczwsy75zHlJQrtoB9OAR8_-cWTzHY2WQXPNZDAfHOWQ9HnKP2aRq1z3r5_Iw-DnpM8OXlvER_f3x_unuoHn___HV3-1gZLmiuuLSDBGGprodGQ61N30guBjF0pgdNtLFtT4WVreEN16UUWBCib2Vb6jU9v0TXp9yy13MpkNXeJQNjWQTCnBSTtO2aWtasoOyEmhhSijCoqbjV8agoUYtttVWLbbXYVifbZejqJX_u92DfRl71FuDmBEBpeXAQVTIOvAHrIpisbHDv5f8HBc2S0g</recordid><startdate>202404</startdate><enddate>202404</enddate><creator>Dedinská, Ivana</creator><creator>Kleinová, Patrícia</creator><creator>Macháleková, Katarína</creator><creator>Graňák, Karol</creator><creator>Vnučák, Matej</creator><creator>Beliančinová, Monika</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202404</creationdate><title>The role of hyperleptinaemia and low values of interleukin 10 in de novo DSA production after kidney transplantation</title><author>Dedinská, Ivana ; Kleinová, Patrícia ; Macháleková, Katarína ; Graňák, Karol ; Vnučák, Matej ; Beliančinová, Monika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-39df9e5d1a4f6ae4acb6935f5f8cbea0acd7b15d97c363a382ede55b7972186b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adiponectin</topic><topic>Graft Rejection - etiology</topic><topic>Graft Survival</topic><topic>IL-10</topic><topic>Interleukin-10</topic><topic>Isoantibodies</topic><topic>Kidney transplantation</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Leptin</topic><topic>Protocol biopsy</topic><topic>Retrospective Studies</topic><topic>Tissue Donors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dedinská, Ivana</creatorcontrib><creatorcontrib>Kleinová, Patrícia</creatorcontrib><creatorcontrib>Macháleková, Katarína</creatorcontrib><creatorcontrib>Graňák, Karol</creatorcontrib><creatorcontrib>Vnučák, Matej</creatorcontrib><creatorcontrib>Beliančinová, Monika</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dedinská, Ivana</au><au>Kleinová, Patrícia</au><au>Macháleková, Katarína</au><au>Graňák, Karol</au><au>Vnučák, Matej</au><au>Beliančinová, Monika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of hyperleptinaemia and low values of interleukin 10 in de novo DSA production after kidney transplantation</atitle><jtitle>Transplant immunology</jtitle><addtitle>Transpl Immunol</addtitle><date>2024-04</date><risdate>2024</risdate><volume>83</volume><spage>101982</spage><epage>101982</epage><pages>101982-101982</pages><artnum>101982</artnum><issn>0966-3274</issn><eissn>1878-5492</eissn><abstract>White adipose tissue secretes a number of peptide hormones. The aim of this paper was to determine the role of leptin, adiponectin and interleukin-10 and interleukin-6 on the development of graft rejection in protocol biopsy after kidney transplantation.
In a prospective analysis (n = 104), we monitored the values of leptin, adiponectin, IL-6, and IL-10 prior to the transplantation and in the 3rd month after the transplantation. The protocol biopsy of the graft was performed in the 3rd month after the transplantation. The group was divided into the following according to the biopsy result: negative result, IFTA 1, borderline, and DSA positive.
After adjusting for the differences in the baseline recipient and donor characteristics, we identified the hyperleptinaemia baseline (HR = 2.0444, P = 0.0341) and month 3 (HR = 49.8043, P < 0.0001) as independent risk factors for borderline changes in the protocol biopsy. The hyperleptinaemia baseline (HR = 7.4979, P = 0.0071) and month 3 (HR = 9.7432, P = 0.0057) are independent risk factors for de novo DSA positivity. A low value of IL-10 month 3 is a risk factor for de novo DSA positivity (HR = 3.0746, P = 0.0388).
Higher leptin levels and low values of IL-10 might play a role in rejection and de novo DSA production.
•The hyperleptinaemia baseline and month 3 as independent risk factors for borderline changes in protocol biopsies.•The hyperleptinaemia baseline and month 3 as independent risk factors for de novo donor specific antibodies production.•Hypo-IL-10 as an independent risk factor for donor specific antibodies positivity in the 3rd month after transplantation.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38218229</pmid><doi>10.1016/j.trim.2023.101982</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adiponectin Graft Rejection - etiology Graft Survival IL-10 Interleukin-10 Isoantibodies Kidney transplantation Kidney Transplantation - adverse effects Leptin Protocol biopsy Retrospective Studies Tissue Donors |
| title | The role of hyperleptinaemia and low values of interleukin 10 in de novo DSA production after kidney transplantation |
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