Mogroside V alleviates inflammation response by modulating miR-21-5P/SPRY1 axis
Mogroside V (MV) is a natural sweetener extracted from the edible plant Siraitia grosvenorii that possesses anti-inflammatory bioactivity. It has been reported that microRNAs (miRNAs) play an important role in the inflammation response suppression by natural agents. However, whether the anti-inflamm...
Gespeichert in:
| Veröffentlicht in: | Food & function 2024-02, Vol.15 (4), p.199-1922 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1922 |
|---|---|
| container_issue | 4 |
| container_start_page | 199 |
| container_title | Food & function |
| container_volume | 15 |
| creator | Han, Mengjie Liu, Haiping Liu, Guoxiang Li, Xiaojuan Zhou, Luwei Liu, Yisa Dou, Tong Yang, Sijie Tang, Wei Wang, Yan Li, Linjun Ding, Hongfang Liu, Zhangchi Wang, Juan Chen, Xu |
| description | Mogroside V (MV) is a natural sweetener extracted from the edible plant
Siraitia grosvenorii
that possesses anti-inflammatory bioactivity. It has been reported that microRNAs (miRNAs) play an important role in the inflammation response suppression by natural agents. However, whether the anti-inflammation effect of mogroside V is related to miRNAs and the underlying mechanism remains unclear. Our study aimed to identify the key miRNAs important for the anti-inflammation effect of MV and reveal its underlying mechanisms. Our results showed that MV effectively alleviated lung inflammation in ovalbumin-induced (OVA-induced) asthmatic mice. miRNA-seq and mRNA-seq combined analysis identified miR-21-5p as an important miRNA for the inflammation inhibition effect of MV and it predicted SPRY1 to be a target gene of miR-21-5p. We found that MV significantly inhibited the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6), and nitric oxide (NO), as well as the protein expression of p-P65/P65, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in OVA-induced asthmatic mice and LPS-treated RAW 264.7 cells. Moreover, the release of ROS increased in LPS-stimulated RAW 264.7 cells but was mitigated by MV pretreatment. In the meantime, the expression of miR-21-5p was decreased by MV, leading to an increase in the expression of SPRY1 in RAW 264.7 cells. Furthermore, miR-21-5p overexpression or SPRY1 knockdown reversed MV's protective effect on inflammatory responses. Conversely, miR-21-5p inhibition or SPRY1 overexpression enhanced MV's effect on inflammatory responses in LPS-exposed RAW 264.7 cells. Therefore, the significant protective effect of mogroside V on inflammation response is related to the downregulation of miR-21-5p and upregulation of SPRY1
in vitro
and
in vivo
, MiR-21-5p/SPRY1 may be novel therapeutic targets of MV for anti-inflammation treatment.
Mogroside V (MV) is a natural sweetener extracted from the edible plant
Siraitia grosvenorii
that possesses anti-inflammatory bioactivity. |
| doi_str_mv | 10.1039/d3fo01901b |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2917862605</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2917862605</sourcerecordid><originalsourceid>FETCH-LOGICAL-c296t-7d7cf53989b5124aff1d40ac06b577ff24b618b66c150b9966b16e06850bc26c3</originalsourceid><addsrcrecordid>eNpd0VtLwzAUB_AgihtzL74rBV9EqMulTZNHnU6Fyca8oE8lSZPR0TazacV9e6O7COYlOcmPw-EfAI4RvESQ8EFGjIWIQyT3QBfDCIc0hm_723PEaQf0nVtAvwjnjLND0CEMx4xz3AWTRzuvrcszHbwGoij0Zy4a7YK8MoUoS9Hktgpq7Za2cjqQq6C0WVv462oelPksxCiMp4On6ewdBeIrd0fgwIjC6f5m74GX0e3z8D4cT-4ehlfjUGFOmzDJEmVi4seRMcKRMAZlERQKUhkniTE4khQxSalCMZScUyoR1ZAyXylMFemB83XfZW0_Wu2atMyd0kUhKm1bl2KOEkYxhbGnZ__owrZ15afzCjPEIEuoVxdrpXwcrtYmXdZ5KepVimD6k3R6Q0aT36SvPT7dtGxlqbMd3ebqwcka1E7tXv--inwDujuABw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2928180876</pqid></control><display><type>article</type><title>Mogroside V alleviates inflammation response by modulating miR-21-5P/SPRY1 axis</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><creator>Han, Mengjie ; Liu, Haiping ; Liu, Guoxiang ; Li, Xiaojuan ; Zhou, Luwei ; Liu, Yisa ; Dou, Tong ; Yang, Sijie ; Tang, Wei ; Wang, Yan ; Li, Linjun ; Ding, Hongfang ; Liu, Zhangchi ; Wang, Juan ; Chen, Xu</creator><creatorcontrib>Han, Mengjie ; Liu, Haiping ; Liu, Guoxiang ; Li, Xiaojuan ; Zhou, Luwei ; Liu, Yisa ; Dou, Tong ; Yang, Sijie ; Tang, Wei ; Wang, Yan ; Li, Linjun ; Ding, Hongfang ; Liu, Zhangchi ; Wang, Juan ; Chen, Xu</creatorcontrib><description>Mogroside V (MV) is a natural sweetener extracted from the edible plant
Siraitia grosvenorii
that possesses anti-inflammatory bioactivity. It has been reported that microRNAs (miRNAs) play an important role in the inflammation response suppression by natural agents. However, whether the anti-inflammation effect of mogroside V is related to miRNAs and the underlying mechanism remains unclear. Our study aimed to identify the key miRNAs important for the anti-inflammation effect of MV and reveal its underlying mechanisms. Our results showed that MV effectively alleviated lung inflammation in ovalbumin-induced (OVA-induced) asthmatic mice. miRNA-seq and mRNA-seq combined analysis identified miR-21-5p as an important miRNA for the inflammation inhibition effect of MV and it predicted SPRY1 to be a target gene of miR-21-5p. We found that MV significantly inhibited the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6), and nitric oxide (NO), as well as the protein expression of p-P65/P65, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in OVA-induced asthmatic mice and LPS-treated RAW 264.7 cells. Moreover, the release of ROS increased in LPS-stimulated RAW 264.7 cells but was mitigated by MV pretreatment. In the meantime, the expression of miR-21-5p was decreased by MV, leading to an increase in the expression of SPRY1 in RAW 264.7 cells. Furthermore, miR-21-5p overexpression or SPRY1 knockdown reversed MV's protective effect on inflammatory responses. Conversely, miR-21-5p inhibition or SPRY1 overexpression enhanced MV's effect on inflammatory responses in LPS-exposed RAW 264.7 cells. Therefore, the significant protective effect of mogroside V on inflammation response is related to the downregulation of miR-21-5p and upregulation of SPRY1
in vitro
and
in vivo
, MiR-21-5p/SPRY1 may be novel therapeutic targets of MV for anti-inflammation treatment.
Mogroside V (MV) is a natural sweetener extracted from the edible plant
Siraitia grosvenorii
that possesses anti-inflammatory bioactivity.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d3fo01901b</identifier><identifier>PMID: 38258992</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Anti-Inflammatory Agents - pharmacology ; Asthma ; Biological activity ; Chromosome 5 ; Cyclooxygenase-2 ; Cytokines ; Inflammation ; Inflammation - drug therapy ; Inflammation - genetics ; Interleukin 2 ; Interleukin 6 ; Interleukin-6 - metabolism ; Interleukins ; Lipopolysaccharides ; Lipopolysaccharides - pharmacology ; Mice ; MicroRNAs ; MicroRNAs - genetics ; MicroRNAs - metabolism ; miRNA ; mRNA ; Nitric oxide ; Nitric-oxide synthase ; Ovalbumin ; Plant extracts ; Therapeutic targets ; Triterpenes ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Food & function, 2024-02, Vol.15 (4), p.199-1922</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c296t-7d7cf53989b5124aff1d40ac06b577ff24b618b66c150b9966b16e06850bc26c3</cites><orcidid>0000-0003-4910-9608</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38258992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Mengjie</creatorcontrib><creatorcontrib>Liu, Haiping</creatorcontrib><creatorcontrib>Liu, Guoxiang</creatorcontrib><creatorcontrib>Li, Xiaojuan</creatorcontrib><creatorcontrib>Zhou, Luwei</creatorcontrib><creatorcontrib>Liu, Yisa</creatorcontrib><creatorcontrib>Dou, Tong</creatorcontrib><creatorcontrib>Yang, Sijie</creatorcontrib><creatorcontrib>Tang, Wei</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Li, Linjun</creatorcontrib><creatorcontrib>Ding, Hongfang</creatorcontrib><creatorcontrib>Liu, Zhangchi</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Chen, Xu</creatorcontrib><title>Mogroside V alleviates inflammation response by modulating miR-21-5P/SPRY1 axis</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Mogroside V (MV) is a natural sweetener extracted from the edible plant
Siraitia grosvenorii
that possesses anti-inflammatory bioactivity. It has been reported that microRNAs (miRNAs) play an important role in the inflammation response suppression by natural agents. However, whether the anti-inflammation effect of mogroside V is related to miRNAs and the underlying mechanism remains unclear. Our study aimed to identify the key miRNAs important for the anti-inflammation effect of MV and reveal its underlying mechanisms. Our results showed that MV effectively alleviated lung inflammation in ovalbumin-induced (OVA-induced) asthmatic mice. miRNA-seq and mRNA-seq combined analysis identified miR-21-5p as an important miRNA for the inflammation inhibition effect of MV and it predicted SPRY1 to be a target gene of miR-21-5p. We found that MV significantly inhibited the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6), and nitric oxide (NO), as well as the protein expression of p-P65/P65, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in OVA-induced asthmatic mice and LPS-treated RAW 264.7 cells. Moreover, the release of ROS increased in LPS-stimulated RAW 264.7 cells but was mitigated by MV pretreatment. In the meantime, the expression of miR-21-5p was decreased by MV, leading to an increase in the expression of SPRY1 in RAW 264.7 cells. Furthermore, miR-21-5p overexpression or SPRY1 knockdown reversed MV's protective effect on inflammatory responses. Conversely, miR-21-5p inhibition or SPRY1 overexpression enhanced MV's effect on inflammatory responses in LPS-exposed RAW 264.7 cells. Therefore, the significant protective effect of mogroside V on inflammation response is related to the downregulation of miR-21-5p and upregulation of SPRY1
in vitro
and
in vivo
, MiR-21-5p/SPRY1 may be novel therapeutic targets of MV for anti-inflammation treatment.
Mogroside V (MV) is a natural sweetener extracted from the edible plant
Siraitia grosvenorii
that possesses anti-inflammatory bioactivity.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Asthma</subject><subject>Biological activity</subject><subject>Chromosome 5</subject><subject>Cyclooxygenase-2</subject><subject>Cytokines</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - genetics</subject><subject>Interleukin 2</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - metabolism</subject><subject>Interleukins</subject><subject>Lipopolysaccharides</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Mice</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>miRNA</subject><subject>mRNA</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>Ovalbumin</subject><subject>Plant extracts</subject><subject>Therapeutic targets</subject><subject>Triterpenes</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0VtLwzAUB_AgihtzL74rBV9EqMulTZNHnU6Fyca8oE8lSZPR0TazacV9e6O7COYlOcmPw-EfAI4RvESQ8EFGjIWIQyT3QBfDCIc0hm_723PEaQf0nVtAvwjnjLND0CEMx4xz3AWTRzuvrcszHbwGoij0Zy4a7YK8MoUoS9Hktgpq7Za2cjqQq6C0WVv462oelPksxCiMp4On6ewdBeIrd0fgwIjC6f5m74GX0e3z8D4cT-4ehlfjUGFOmzDJEmVi4seRMcKRMAZlERQKUhkniTE4khQxSalCMZScUyoR1ZAyXylMFemB83XfZW0_Wu2atMyd0kUhKm1bl2KOEkYxhbGnZ__owrZ15afzCjPEIEuoVxdrpXwcrtYmXdZ5KepVimD6k3R6Q0aT36SvPT7dtGxlqbMd3ebqwcka1E7tXv--inwDujuABw</recordid><startdate>20240219</startdate><enddate>20240219</enddate><creator>Han, Mengjie</creator><creator>Liu, Haiping</creator><creator>Liu, Guoxiang</creator><creator>Li, Xiaojuan</creator><creator>Zhou, Luwei</creator><creator>Liu, Yisa</creator><creator>Dou, Tong</creator><creator>Yang, Sijie</creator><creator>Tang, Wei</creator><creator>Wang, Yan</creator><creator>Li, Linjun</creator><creator>Ding, Hongfang</creator><creator>Liu, Zhangchi</creator><creator>Wang, Juan</creator><creator>Chen, Xu</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4910-9608</orcidid></search><sort><creationdate>20240219</creationdate><title>Mogroside V alleviates inflammation response by modulating miR-21-5P/SPRY1 axis</title><author>Han, Mengjie ; Liu, Haiping ; Liu, Guoxiang ; Li, Xiaojuan ; Zhou, Luwei ; Liu, Yisa ; Dou, Tong ; Yang, Sijie ; Tang, Wei ; Wang, Yan ; Li, Linjun ; Ding, Hongfang ; Liu, Zhangchi ; Wang, Juan ; Chen, Xu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-7d7cf53989b5124aff1d40ac06b577ff24b618b66c150b9966b16e06850bc26c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Asthma</topic><topic>Biological activity</topic><topic>Chromosome 5</topic><topic>Cyclooxygenase-2</topic><topic>Cytokines</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - genetics</topic><topic>Interleukin 2</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - metabolism</topic><topic>Interleukins</topic><topic>Lipopolysaccharides</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Mice</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>miRNA</topic><topic>mRNA</topic><topic>Nitric oxide</topic><topic>Nitric-oxide synthase</topic><topic>Ovalbumin</topic><topic>Plant extracts</topic><topic>Therapeutic targets</topic><topic>Triterpenes</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Mengjie</creatorcontrib><creatorcontrib>Liu, Haiping</creatorcontrib><creatorcontrib>Liu, Guoxiang</creatorcontrib><creatorcontrib>Li, Xiaojuan</creatorcontrib><creatorcontrib>Zhou, Luwei</creatorcontrib><creatorcontrib>Liu, Yisa</creatorcontrib><creatorcontrib>Dou, Tong</creatorcontrib><creatorcontrib>Yang, Sijie</creatorcontrib><creatorcontrib>Tang, Wei</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Li, Linjun</creatorcontrib><creatorcontrib>Ding, Hongfang</creatorcontrib><creatorcontrib>Liu, Zhangchi</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Chen, Xu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Mengjie</au><au>Liu, Haiping</au><au>Liu, Guoxiang</au><au>Li, Xiaojuan</au><au>Zhou, Luwei</au><au>Liu, Yisa</au><au>Dou, Tong</au><au>Yang, Sijie</au><au>Tang, Wei</au><au>Wang, Yan</au><au>Li, Linjun</au><au>Ding, Hongfang</au><au>Liu, Zhangchi</au><au>Wang, Juan</au><au>Chen, Xu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mogroside V alleviates inflammation response by modulating miR-21-5P/SPRY1 axis</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2024-02-19</date><risdate>2024</risdate><volume>15</volume><issue>4</issue><spage>199</spage><epage>1922</epage><pages>199-1922</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Mogroside V (MV) is a natural sweetener extracted from the edible plant
Siraitia grosvenorii
that possesses anti-inflammatory bioactivity. It has been reported that microRNAs (miRNAs) play an important role in the inflammation response suppression by natural agents. However, whether the anti-inflammation effect of mogroside V is related to miRNAs and the underlying mechanism remains unclear. Our study aimed to identify the key miRNAs important for the anti-inflammation effect of MV and reveal its underlying mechanisms. Our results showed that MV effectively alleviated lung inflammation in ovalbumin-induced (OVA-induced) asthmatic mice. miRNA-seq and mRNA-seq combined analysis identified miR-21-5p as an important miRNA for the inflammation inhibition effect of MV and it predicted SPRY1 to be a target gene of miR-21-5p. We found that MV significantly inhibited the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6), and nitric oxide (NO), as well as the protein expression of p-P65/P65, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in OVA-induced asthmatic mice and LPS-treated RAW 264.7 cells. Moreover, the release of ROS increased in LPS-stimulated RAW 264.7 cells but was mitigated by MV pretreatment. In the meantime, the expression of miR-21-5p was decreased by MV, leading to an increase in the expression of SPRY1 in RAW 264.7 cells. Furthermore, miR-21-5p overexpression or SPRY1 knockdown reversed MV's protective effect on inflammatory responses. Conversely, miR-21-5p inhibition or SPRY1 overexpression enhanced MV's effect on inflammatory responses in LPS-exposed RAW 264.7 cells. Therefore, the significant protective effect of mogroside V on inflammation response is related to the downregulation of miR-21-5p and upregulation of SPRY1
in vitro
and
in vivo
, MiR-21-5p/SPRY1 may be novel therapeutic targets of MV for anti-inflammation treatment.
Mogroside V (MV) is a natural sweetener extracted from the edible plant
Siraitia grosvenorii
that possesses anti-inflammatory bioactivity.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>38258992</pmid><doi>10.1039/d3fo01901b</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-4910-9608</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2042-6496 |
| ispartof | Food & function, 2024-02, Vol.15 (4), p.199-1922 |
| issn | 2042-6496 2042-650X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2917862605 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Animals Anti-Inflammatory Agents - pharmacology Asthma Biological activity Chromosome 5 Cyclooxygenase-2 Cytokines Inflammation Inflammation - drug therapy Inflammation - genetics Interleukin 2 Interleukin 6 Interleukin-6 - metabolism Interleukins Lipopolysaccharides Lipopolysaccharides - pharmacology Mice MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA mRNA Nitric oxide Nitric-oxide synthase Ovalbumin Plant extracts Therapeutic targets Triterpenes Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Mogroside V alleviates inflammation response by modulating miR-21-5P/SPRY1 axis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T00%3A35%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mogroside%20V%20alleviates%20inflammation%20response%20by%20modulating%20miR-21-5P/SPRY1%20axis&rft.jtitle=Food%20&%20function&rft.au=Han,%20Mengjie&rft.date=2024-02-19&rft.volume=15&rft.issue=4&rft.spage=199&rft.epage=1922&rft.pages=199-1922&rft.issn=2042-6496&rft.eissn=2042-650X&rft_id=info:doi/10.1039/d3fo01901b&rft_dat=%3Cproquest_cross%3E2917862605%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2928180876&rft_id=info:pmid/38258992&rfr_iscdi=true |