Leveraging external control data in the design and analysis of neuro-oncology trials: Pearls and perils

Abstract Background Randomized controlled trials have been the gold standard for evaluating medical treatments for many decades but they are often criticized for requiring large sample sizes. Given the urgent need for better therapies for glioblastoma, it has been argued that data collected from pat...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2024-05, Vol.26 (5), p.796-810
Hauptverfasser:	Polley, Mei-Yin C, Schwartz, Daniel, Karrison, Theodore, Dignam, James J
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - therapy Clinical Trials as Topic - standards Glioblastoma - therapy Humans Randomized Controlled Trials as Topic - methods Research Design - standards
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