Obesity Is Associated with Distal Migration of Pancreatic Adenocarcinoma to Body and Tail: A Multi-Center Study
(1) Background: Pancreatic adenocarcinoma (PAC) is one of the most lethal types of cancer. Most cases of PAC occur in the head of the pancreas. Given the proximity of the pancreatic head to the bile duct, most patients present clinically during early stages of the disease, while distally located PAC...
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| Veröffentlicht in: | Cancers 2024-01, Vol.16 (2), p.359 |
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| description | (1) Background: Pancreatic adenocarcinoma (PAC) is one of the most lethal types of cancer. Most cases of PAC occur in the head of the pancreas. Given the proximity of the pancreatic head to the bile duct, most patients present clinically during early stages of the disease, while distally located PAC could have delayed clinical presentation. (2) Aims: To assess predictors of non-head PAC. (3) Methods: A retrospective multicenter study was conducted, including all patients who had endoscopic ultrasound (EUS) for pancreatic masses and who had histologic confirmation of PAC. (4) Results: Of the 151 patients included, 92 (60.9%) had pancreatic head cancer, and 59 (39.1%) had distal pancreatic cancer. PAC at body was the most common location in the distal PAC group (31 patients (52.5%)). Logistic regression analysis demonstrated a significant association of obesity with distal migration of PAC (OR 4.44, 95% CI 1.15-17.19,
= 0.03), while none of the other assessed parameters showed a significant association. Notably, abdominal pain was more significantly associated with distal PAC vs. head location (OR 2.85, 95% CI 1.32-6.16,
= 0.008). (5) Conclusions: Obesity shows a significant association as a clinical predictor of distal PAC. Further studies are needed to better explore this association. |
| doi_str_mv | 10.3390/cancers16020359 |
| format | Article |
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= 0.03), while none of the other assessed parameters showed a significant association. Notably, abdominal pain was more significantly associated with distal PAC vs. head location (OR 2.85, 95% CI 1.32-6.16,
= 0.008). (5) Conclusions: Obesity shows a significant association as a clinical predictor of distal PAC. Further studies are needed to better explore this association.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers16020359</identifier><identifier>PMID: 38254848</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Abdomen ; Adenocarcinoma ; Alcohol ; Asymptomatic ; Bile ducts ; Body mass index ; Cancer ; Demographics ; Development and progression ; Diabetes ; Disease ; Endoscopy ; Family medical history ; Infection control ; Medical prognosis ; Metabolic syndrome ; Metastasis ; Migration ; Mortality ; Obesity ; Oncology, Experimental ; Pain ; Pancreatic cancer ; Regression analysis ; Systematic review ; Tumors ; Ultrasonic imaging ; Weight control</subject><ispartof>Cancers, 2024-01, Vol.16 (2), p.359</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c387t-718572b1e0cc2a4fec862568b7c4aa3a2b77b37343a2f4f78f45f870381e5b923</cites><orcidid>0000-0001-6699-8625 ; 0000-0002-0921-4676</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38254848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sbeit, Wisam</creatorcontrib><creatorcontrib>Gershovitz, Gil</creatorcontrib><creatorcontrib>Shahin, Amir</creatorcontrib><creatorcontrib>Shhadeh, Shhady</creatorcontrib><creatorcontrib>Salman, Mahmoud</creatorcontrib><creatorcontrib>Basheer, Maamoun</creatorcontrib><creatorcontrib>Khoury, Tawfik</creatorcontrib><title>Obesity Is Associated with Distal Migration of Pancreatic Adenocarcinoma to Body and Tail: A Multi-Center Study</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>(1) Background: Pancreatic adenocarcinoma (PAC) is one of the most lethal types of cancer. Most cases of PAC occur in the head of the pancreas. Given the proximity of the pancreatic head to the bile duct, most patients present clinically during early stages of the disease, while distally located PAC could have delayed clinical presentation. (2) Aims: To assess predictors of non-head PAC. (3) Methods: A retrospective multicenter study was conducted, including all patients who had endoscopic ultrasound (EUS) for pancreatic masses and who had histologic confirmation of PAC. (4) Results: Of the 151 patients included, 92 (60.9%) had pancreatic head cancer, and 59 (39.1%) had distal pancreatic cancer. PAC at body was the most common location in the distal PAC group (31 patients (52.5%)). Logistic regression analysis demonstrated a significant association of obesity with distal migration of PAC (OR 4.44, 95% CI 1.15-17.19,
= 0.03), while none of the other assessed parameters showed a significant association. Notably, abdominal pain was more significantly associated with distal PAC vs. head location (OR 2.85, 95% CI 1.32-6.16,
= 0.008). (5) Conclusions: Obesity shows a significant association as a clinical predictor of distal PAC. Further studies are needed to better explore this association.</description><subject>Abdomen</subject><subject>Adenocarcinoma</subject><subject>Alcohol</subject><subject>Asymptomatic</subject><subject>Bile ducts</subject><subject>Body mass index</subject><subject>Cancer</subject><subject>Demographics</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Endoscopy</subject><subject>Family medical history</subject><subject>Infection control</subject><subject>Medical prognosis</subject><subject>Metabolic syndrome</subject><subject>Metastasis</subject><subject>Migration</subject><subject>Mortality</subject><subject>Obesity</subject><subject>Oncology, Experimental</subject><subject>Pain</subject><subject>Pancreatic cancer</subject><subject>Regression analysis</subject><subject>Systematic review</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><subject>Weight control</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkc1LHTEUxUNpqaKuuyuBbroZzSSZSaa76euXoFhQ18OdzI2NzCQ2ySDvv28e2mLFm8W9Cb9zcuEQ8q5mx0J07MSANxhT3TLORNO9IvucKV61bSdfP5n3yFFKt6yUELVq1VuyJzRvpJZ6n4SLEZPLW3qaaJ9SMA4yTvTe5V_0i0sZZnrubiJkFzwNlv4sf0YsV0P7CX0wEI3zYQGaA_0cpi0FP9ErcPMn2tPzdc6u2qDPGOllXqftIXljYU549NgPyPW3r1ebH9XZxffTTX9WGaFVrlStG8XHGpkxHKRFo1vetHpURgII4KNSo1BCltFKq7SVjdWKCV1jM3ZcHJCPD753MfxeMeVhccngPIPHsKaBd7XSLZO6K-iHZ-htWKMv2-0o3chGiyfUDcw4OG9DjmB2pkOvNNOKd50q1PELVDkTLs4Ej9aV9_8EJw8CE0NKEe1wF90CcTvUbNilPDxLuSjeP667jgtO__i_mYo_HTehGA</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Sbeit, Wisam</creator><creator>Gershovitz, Gil</creator><creator>Shahin, Amir</creator><creator>Shhadeh, Shhady</creator><creator>Salman, Mahmoud</creator><creator>Basheer, Maamoun</creator><creator>Khoury, Tawfik</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6699-8625</orcidid><orcidid>https://orcid.org/0000-0002-0921-4676</orcidid></search><sort><creationdate>20240101</creationdate><title>Obesity Is Associated with Distal Migration of Pancreatic Adenocarcinoma to Body and Tail: A Multi-Center Study</title><author>Sbeit, Wisam ; Gershovitz, Gil ; Shahin, Amir ; Shhadeh, Shhady ; Salman, Mahmoud ; Basheer, Maamoun ; Khoury, Tawfik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-718572b1e0cc2a4fec862568b7c4aa3a2b77b37343a2f4f78f45f870381e5b923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abdomen</topic><topic>Adenocarcinoma</topic><topic>Alcohol</topic><topic>Asymptomatic</topic><topic>Bile ducts</topic><topic>Body mass index</topic><topic>Cancer</topic><topic>Demographics</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Disease</topic><topic>Endoscopy</topic><topic>Family medical history</topic><topic>Infection control</topic><topic>Medical prognosis</topic><topic>Metabolic syndrome</topic><topic>Metastasis</topic><topic>Migration</topic><topic>Mortality</topic><topic>Obesity</topic><topic>Oncology, Experimental</topic><topic>Pain</topic><topic>Pancreatic cancer</topic><topic>Regression analysis</topic><topic>Systematic review</topic><topic>Tumors</topic><topic>Ultrasonic imaging</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sbeit, Wisam</creatorcontrib><creatorcontrib>Gershovitz, Gil</creatorcontrib><creatorcontrib>Shahin, Amir</creatorcontrib><creatorcontrib>Shhadeh, Shhady</creatorcontrib><creatorcontrib>Salman, Mahmoud</creatorcontrib><creatorcontrib>Basheer, Maamoun</creatorcontrib><creatorcontrib>Khoury, Tawfik</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sbeit, Wisam</au><au>Gershovitz, Gil</au><au>Shahin, Amir</au><au>Shhadeh, Shhady</au><au>Salman, Mahmoud</au><au>Basheer, Maamoun</au><au>Khoury, Tawfik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity Is Associated with Distal Migration of Pancreatic Adenocarcinoma to Body and Tail: A Multi-Center Study</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>16</volume><issue>2</issue><spage>359</spage><pages>359-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>(1) Background: Pancreatic adenocarcinoma (PAC) is one of the most lethal types of cancer. Most cases of PAC occur in the head of the pancreas. Given the proximity of the pancreatic head to the bile duct, most patients present clinically during early stages of the disease, while distally located PAC could have delayed clinical presentation. (2) Aims: To assess predictors of non-head PAC. (3) Methods: A retrospective multicenter study was conducted, including all patients who had endoscopic ultrasound (EUS) for pancreatic masses and who had histologic confirmation of PAC. (4) Results: Of the 151 patients included, 92 (60.9%) had pancreatic head cancer, and 59 (39.1%) had distal pancreatic cancer. PAC at body was the most common location in the distal PAC group (31 patients (52.5%)). Logistic regression analysis demonstrated a significant association of obesity with distal migration of PAC (OR 4.44, 95% CI 1.15-17.19,
= 0.03), while none of the other assessed parameters showed a significant association. Notably, abdominal pain was more significantly associated with distal PAC vs. head location (OR 2.85, 95% CI 1.32-6.16,
= 0.008). (5) Conclusions: Obesity shows a significant association as a clinical predictor of distal PAC. Further studies are needed to better explore this association.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38254848</pmid><doi>10.3390/cancers16020359</doi><orcidid>https://orcid.org/0000-0001-6699-8625</orcidid><orcidid>https://orcid.org/0000-0002-0921-4676</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen Adenocarcinoma Alcohol Asymptomatic Bile ducts Body mass index Cancer Demographics Development and progression Diabetes Disease Endoscopy Family medical history Infection control Medical prognosis Metabolic syndrome Metastasis Migration Mortality Obesity Oncology, Experimental Pain Pancreatic cancer Regression analysis Systematic review Tumors Ultrasonic imaging Weight control |
| title | Obesity Is Associated with Distal Migration of Pancreatic Adenocarcinoma to Body and Tail: A Multi-Center Study |
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