Clinical and prognostic implications of left ventricular dilatation in heart failure
To assess the agreement between left ventricular end-diastolic diameter index (LVEDDi) and volume index (LVEDVi) to define LV dilatation and to investigate the respective prognostic implications in patients with heart failure (HF). Patients with HF symptoms and LV ejection fraction (LVEF)
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| Veröffentlicht in: | European heart journal cardiovascular imaging 2024-05, Vol.25 (6), p.849-856 |
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| container_title | European heart journal cardiovascular imaging |
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| creator | Kasa, Gizem Teis, Albert Juncà, Gladys Aimo, Alberto Lupón, Josep Cediel, German Santiago-Vacas, Evelyn Codina, Pau Ferrer-Sistach, Elena Vallejo-Camazón, Nuria López-Ayerbe, Jorge Bayés-Genis, Antoni Delgado, Victoria |
| description | To assess the agreement between left ventricular end-diastolic diameter index (LVEDDi) and volume index (LVEDVi) to define LV dilatation and to investigate the respective prognostic implications in patients with heart failure (HF).
Patients with HF symptoms and LV ejection fraction (LVEF) |
| doi_str_mv | 10.1093/ehjci/jeae025 |
| format | Article |
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Patients with HF symptoms and LV ejection fraction (LVEF) < 50% undergoing cardiac magnetic resonance (CMR) were evaluated retrospectively. LV dilatation was defined as LVEDDi or LVEDVi above the upper normal limit according to published reference values. Patients were followed-up for the combined endpoint of cardiovascular death or HF hospitalization during 5 years. A total of 564 patients (median age 64 years; 79% men) were included. LVEDDi had a modest correlation with LVEDVi (r = 0.682, p < 0.001). LV dilatation was noted in 84% of patients using LVEDVi-based definition and in 73% using LVEDDi-based definition, whereas 20% of patients displayed discordant definitions of LV dilatation. During a median follow-up of 2.8 years, patients with both dilated LVEDDi and LVEDVi had the highest cumulative event rate (HR 3.00, 95% CI 1.15-7.81, p = 0.024). Both LVEDDi and LVEDVi were independently associated with the primary outcome (hazard ratio 3.29, 95%, p < 0.001 and 2.8, p = 0.009; respectively).
The majority of patients with HF and LVEF < 50% present both increased LVEDDi and LVEDVi whereas 20% show discordant linear and volumetric definitions of LV dilatation. Patients with increased LVEDDi and LVEDVi have the worst clinical outcomes suggesting that the assessment of these two metrics is needed for better risk stratification.</description><identifier>ISSN: 2047-2404</identifier><identifier>EISSN: 2047-2412</identifier><identifier>DOI: 10.1093/ehjci/jeae025</identifier><identifier>PMID: 38246859</identifier><language>eng</language><publisher>England</publisher><ispartof>European heart journal cardiovascular imaging, 2024-05, Vol.25 (6), p.849-856</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c179t-75f6200121770cfa054e75d65acef6c530d72e998af7272c44a5b4053bb674fc3</cites><orcidid>0000-0002-3044-197X ; 0000-0001-7511-406X ; 0000-0002-4421-5658 ; 0000-0001-9129-9519 ; 0000-0002-3981-3020 ; 0000-0001-6644-6767 ; 0000-0002-4820-0736 ; 0000-0002-2469-5711 ; 0000-0002-1795-2193 ; 0000-0002-9841-2737 ; 0000-0001-6560-4575</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38246859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kasa, Gizem</creatorcontrib><creatorcontrib>Teis, Albert</creatorcontrib><creatorcontrib>Juncà, Gladys</creatorcontrib><creatorcontrib>Aimo, Alberto</creatorcontrib><creatorcontrib>Lupón, Josep</creatorcontrib><creatorcontrib>Cediel, German</creatorcontrib><creatorcontrib>Santiago-Vacas, Evelyn</creatorcontrib><creatorcontrib>Codina, Pau</creatorcontrib><creatorcontrib>Ferrer-Sistach, Elena</creatorcontrib><creatorcontrib>Vallejo-Camazón, Nuria</creatorcontrib><creatorcontrib>López-Ayerbe, Jorge</creatorcontrib><creatorcontrib>Bayés-Genis, Antoni</creatorcontrib><creatorcontrib>Delgado, Victoria</creatorcontrib><title>Clinical and prognostic implications of left ventricular dilatation in heart failure</title><title>European heart journal cardiovascular imaging</title><addtitle>Eur Heart J Cardiovasc Imaging</addtitle><description>To assess the agreement between left ventricular end-diastolic diameter index (LVEDDi) and volume index (LVEDVi) to define LV dilatation and to investigate the respective prognostic implications in patients with heart failure (HF).
Patients with HF symptoms and LV ejection fraction (LVEF) < 50% undergoing cardiac magnetic resonance (CMR) were evaluated retrospectively. LV dilatation was defined as LVEDDi or LVEDVi above the upper normal limit according to published reference values. Patients were followed-up for the combined endpoint of cardiovascular death or HF hospitalization during 5 years. A total of 564 patients (median age 64 years; 79% men) were included. LVEDDi had a modest correlation with LVEDVi (r = 0.682, p < 0.001). LV dilatation was noted in 84% of patients using LVEDVi-based definition and in 73% using LVEDDi-based definition, whereas 20% of patients displayed discordant definitions of LV dilatation. During a median follow-up of 2.8 years, patients with both dilated LVEDDi and LVEDVi had the highest cumulative event rate (HR 3.00, 95% CI 1.15-7.81, p = 0.024). Both LVEDDi and LVEDVi were independently associated with the primary outcome (hazard ratio 3.29, 95%, p < 0.001 and 2.8, p = 0.009; respectively).
The majority of patients with HF and LVEF < 50% present both increased LVEDDi and LVEDVi whereas 20% show discordant linear and volumetric definitions of LV dilatation. Patients with increased LVEDDi and LVEDVi have the worst clinical outcomes suggesting that the assessment of these two metrics is needed for better risk stratification.</description><issn>2047-2404</issn><issn>2047-2412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kM1LAzEQxYMottQevUqOXtYm2WTTPUrxCwpe6jlksxObkt2tSVbwvze2te8yw8zj8fghdEvJAyV1uYDtzrjFDjQQJi7QlBEuC8YpuzzvhE_QPMYdyRK84oxeo0m5ZLxainqKNivveme0x7pv8T4Mn_0QkzPYdXuf78kNfcSDxR5swt_Qp-DM6HXArfM6Hf7Y9XgLOiRstfNjgBt0ZbWPMD_NGfp4ftqsXov1-8vb6nFdGCrrVEhhK0YIZVRKYqzO_UCKthLagK2MKEkrGdT1UlvJJDOca9FwIsqmqSS3ppyh-2Nu7v01Qkyqc9GA97qHYYyK1VSKLMaztThaTRhiDGDVPrhOhx9FifpjqQ4s1Yll9t-dosemg_bs_idX_gIRZ3G3</recordid><startdate>20240531</startdate><enddate>20240531</enddate><creator>Kasa, Gizem</creator><creator>Teis, Albert</creator><creator>Juncà, Gladys</creator><creator>Aimo, Alberto</creator><creator>Lupón, Josep</creator><creator>Cediel, German</creator><creator>Santiago-Vacas, Evelyn</creator><creator>Codina, Pau</creator><creator>Ferrer-Sistach, Elena</creator><creator>Vallejo-Camazón, Nuria</creator><creator>López-Ayerbe, Jorge</creator><creator>Bayés-Genis, Antoni</creator><creator>Delgado, Victoria</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3044-197X</orcidid><orcidid>https://orcid.org/0000-0001-7511-406X</orcidid><orcidid>https://orcid.org/0000-0002-4421-5658</orcidid><orcidid>https://orcid.org/0000-0001-9129-9519</orcidid><orcidid>https://orcid.org/0000-0002-3981-3020</orcidid><orcidid>https://orcid.org/0000-0001-6644-6767</orcidid><orcidid>https://orcid.org/0000-0002-4820-0736</orcidid><orcidid>https://orcid.org/0000-0002-2469-5711</orcidid><orcidid>https://orcid.org/0000-0002-1795-2193</orcidid><orcidid>https://orcid.org/0000-0002-9841-2737</orcidid><orcidid>https://orcid.org/0000-0001-6560-4575</orcidid></search><sort><creationdate>20240531</creationdate><title>Clinical and prognostic implications of left ventricular dilatation in heart failure</title><author>Kasa, Gizem ; Teis, Albert ; Juncà, Gladys ; Aimo, Alberto ; Lupón, Josep ; Cediel, German ; Santiago-Vacas, Evelyn ; Codina, Pau ; Ferrer-Sistach, Elena ; Vallejo-Camazón, Nuria ; López-Ayerbe, Jorge ; Bayés-Genis, Antoni ; Delgado, Victoria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c179t-75f6200121770cfa054e75d65acef6c530d72e998af7272c44a5b4053bb674fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kasa, Gizem</creatorcontrib><creatorcontrib>Teis, Albert</creatorcontrib><creatorcontrib>Juncà, Gladys</creatorcontrib><creatorcontrib>Aimo, Alberto</creatorcontrib><creatorcontrib>Lupón, Josep</creatorcontrib><creatorcontrib>Cediel, German</creatorcontrib><creatorcontrib>Santiago-Vacas, Evelyn</creatorcontrib><creatorcontrib>Codina, Pau</creatorcontrib><creatorcontrib>Ferrer-Sistach, Elena</creatorcontrib><creatorcontrib>Vallejo-Camazón, Nuria</creatorcontrib><creatorcontrib>López-Ayerbe, Jorge</creatorcontrib><creatorcontrib>Bayés-Genis, Antoni</creatorcontrib><creatorcontrib>Delgado, Victoria</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal cardiovascular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kasa, Gizem</au><au>Teis, Albert</au><au>Juncà, Gladys</au><au>Aimo, Alberto</au><au>Lupón, Josep</au><au>Cediel, German</au><au>Santiago-Vacas, Evelyn</au><au>Codina, Pau</au><au>Ferrer-Sistach, Elena</au><au>Vallejo-Camazón, Nuria</au><au>López-Ayerbe, Jorge</au><au>Bayés-Genis, Antoni</au><au>Delgado, Victoria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and prognostic implications of left ventricular dilatation in heart failure</atitle><jtitle>European heart journal cardiovascular imaging</jtitle><addtitle>Eur Heart J Cardiovasc Imaging</addtitle><date>2024-05-31</date><risdate>2024</risdate><volume>25</volume><issue>6</issue><spage>849</spage><epage>856</epage><pages>849-856</pages><issn>2047-2404</issn><eissn>2047-2412</eissn><abstract>To assess the agreement between left ventricular end-diastolic diameter index (LVEDDi) and volume index (LVEDVi) to define LV dilatation and to investigate the respective prognostic implications in patients with heart failure (HF).
Patients with HF symptoms and LV ejection fraction (LVEF) < 50% undergoing cardiac magnetic resonance (CMR) were evaluated retrospectively. LV dilatation was defined as LVEDDi or LVEDVi above the upper normal limit according to published reference values. Patients were followed-up for the combined endpoint of cardiovascular death or HF hospitalization during 5 years. A total of 564 patients (median age 64 years; 79% men) were included. LVEDDi had a modest correlation with LVEDVi (r = 0.682, p < 0.001). LV dilatation was noted in 84% of patients using LVEDVi-based definition and in 73% using LVEDDi-based definition, whereas 20% of patients displayed discordant definitions of LV dilatation. During a median follow-up of 2.8 years, patients with both dilated LVEDDi and LVEDVi had the highest cumulative event rate (HR 3.00, 95% CI 1.15-7.81, p = 0.024). Both LVEDDi and LVEDVi were independently associated with the primary outcome (hazard ratio 3.29, 95%, p < 0.001 and 2.8, p = 0.009; respectively).
The majority of patients with HF and LVEF < 50% present both increased LVEDDi and LVEDVi whereas 20% show discordant linear and volumetric definitions of LV dilatation. Patients with increased LVEDDi and LVEDVi have the worst clinical outcomes suggesting that the assessment of these two metrics is needed for better risk stratification.</abstract><cop>England</cop><pmid>38246859</pmid><doi>10.1093/ehjci/jeae025</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3044-197X</orcidid><orcidid>https://orcid.org/0000-0001-7511-406X</orcidid><orcidid>https://orcid.org/0000-0002-4421-5658</orcidid><orcidid>https://orcid.org/0000-0001-9129-9519</orcidid><orcidid>https://orcid.org/0000-0002-3981-3020</orcidid><orcidid>https://orcid.org/0000-0001-6644-6767</orcidid><orcidid>https://orcid.org/0000-0002-4820-0736</orcidid><orcidid>https://orcid.org/0000-0002-2469-5711</orcidid><orcidid>https://orcid.org/0000-0002-1795-2193</orcidid><orcidid>https://orcid.org/0000-0002-9841-2737</orcidid><orcidid>https://orcid.org/0000-0001-6560-4575</orcidid></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current) |
| title | Clinical and prognostic implications of left ventricular dilatation in heart failure |
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