Do IVF culture conditions have an impact on neonatal outcomes? A systematic review and meta-analysis
Purpose Are embryo culture conditions, including type of incubator, oxygen tension, and culture media, associated with obstetric or neonatal complications following in vitro fertilization (IVF)? Methods A systematic search of MEDLINE, EMBASE, and Cochrane Library was performed from January 01, 2008,...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2024-03, Vol.41 (3), p.563-580 |
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| container_title | Journal of assisted reproduction and genetics |
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| creator | Sonigo, Charlotte Ahdad-Yata, Naouel Pirtea, Paul Solignac, Céline Grynberg, Michael Sermondade, Nathalie |
| description | Purpose
Are embryo culture conditions, including type of incubator, oxygen tension, and culture media, associated with obstetric or neonatal complications following in vitro fertilization (IVF)?
Methods
A systematic search of MEDLINE, EMBASE, and Cochrane Library was performed from January 01, 2008, until October 31, 2021. The studies reporting quantitative data on at least one of the primary outcomes (birthweight and preterm birth) for the exposure group and the control group were included. For oxygen tension, independent meta-analysis was performed using Review Manager, comparing hypoxia/normoxia. For culture media, a network meta-analysis was carried out using R software, allowing the inclusion of articles comparing two or more culture media.
Results
After reviewing 182 records, 39 full-text articles were assessed for eligibility. A total of 28 studies were kept for review. Meta-analysis about the impact of incubator type on perinatal outcomes could not be carried out because of a limited number of studies. For oxygen tension, three studies were included. The pairwise meta-analysis comparing hypoxia/normoxia did not show any statistical difference for birthweight and gestational age at birth. For culture media, 18 studies were included. The network meta-analysis failed to reveal any significant impact of different culture media on birthweight or preterm birth.
Conclusion
No difference was observed for neonatal outcomes according to the embryo culture conditions evaluated in this review. Further research is needed about the safety of IVF culture conditions as far as future children’s health is concerned. |
| doi_str_mv | 10.1007/s10815-024-03020-0 |
| format | Article |
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Are embryo culture conditions, including type of incubator, oxygen tension, and culture media, associated with obstetric or neonatal complications following in vitro fertilization (IVF)?
Methods
A systematic search of MEDLINE, EMBASE, and Cochrane Library was performed from January 01, 2008, until October 31, 2021. The studies reporting quantitative data on at least one of the primary outcomes (birthweight and preterm birth) for the exposure group and the control group were included. For oxygen tension, independent meta-analysis was performed using Review Manager, comparing hypoxia/normoxia. For culture media, a network meta-analysis was carried out using R software, allowing the inclusion of articles comparing two or more culture media.
Results
After reviewing 182 records, 39 full-text articles were assessed for eligibility. A total of 28 studies were kept for review. Meta-analysis about the impact of incubator type on perinatal outcomes could not be carried out because of a limited number of studies. For oxygen tension, three studies were included. The pairwise meta-analysis comparing hypoxia/normoxia did not show any statistical difference for birthweight and gestational age at birth. For culture media, 18 studies were included. The network meta-analysis failed to reveal any significant impact of different culture media on birthweight or preterm birth.
Conclusion
No difference was observed for neonatal outcomes according to the embryo culture conditions evaluated in this review. Further research is needed about the safety of IVF culture conditions as far as future children’s health is concerned.</description><identifier>ISSN: 1058-0468</identifier><identifier>ISSN: 1573-7330</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-024-03020-0</identifier><identifier>PMID: 38246922</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Birth Weight ; Child ; Culture Media ; Female ; Fertilization in Vitro ; Gestational age ; Gynecology ; Human Genetics ; Humans ; Hypoxia ; In vitro fertilization ; Infant, Newborn ; Medicine ; Medicine & Public Health ; Meta-analysis ; Neonates ; Oxygen ; Oxygen tension ; Pregnancy ; Premature Birth ; Reproductive Medicine ; Review ; Reviews</subject><ispartof>Journal of assisted reproduction and genetics, 2024-03, Vol.41 (3), p.563-580</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-dbb55d94ca1da7fcec81caa206f1d2c5ec4eebd0b6fc0de13e21f1cd8e9b9adb3</citedby><cites>FETCH-LOGICAL-c375t-dbb55d94ca1da7fcec81caa206f1d2c5ec4eebd0b6fc0de13e21f1cd8e9b9adb3</cites><orcidid>0000-0002-7044-6935</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10815-024-03020-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10815-024-03020-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38246922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sonigo, Charlotte</creatorcontrib><creatorcontrib>Ahdad-Yata, Naouel</creatorcontrib><creatorcontrib>Pirtea, Paul</creatorcontrib><creatorcontrib>Solignac, Céline</creatorcontrib><creatorcontrib>Grynberg, Michael</creatorcontrib><creatorcontrib>Sermondade, Nathalie</creatorcontrib><title>Do IVF culture conditions have an impact on neonatal outcomes? A systematic review and meta-analysis</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
Are embryo culture conditions, including type of incubator, oxygen tension, and culture media, associated with obstetric or neonatal complications following in vitro fertilization (IVF)?
Methods
A systematic search of MEDLINE, EMBASE, and Cochrane Library was performed from January 01, 2008, until October 31, 2021. The studies reporting quantitative data on at least one of the primary outcomes (birthweight and preterm birth) for the exposure group and the control group were included. For oxygen tension, independent meta-analysis was performed using Review Manager, comparing hypoxia/normoxia. For culture media, a network meta-analysis was carried out using R software, allowing the inclusion of articles comparing two or more culture media.
Results
After reviewing 182 records, 39 full-text articles were assessed for eligibility. A total of 28 studies were kept for review. Meta-analysis about the impact of incubator type on perinatal outcomes could not be carried out because of a limited number of studies. For oxygen tension, three studies were included. The pairwise meta-analysis comparing hypoxia/normoxia did not show any statistical difference for birthweight and gestational age at birth. For culture media, 18 studies were included. The network meta-analysis failed to reveal any significant impact of different culture media on birthweight or preterm birth.
Conclusion
No difference was observed for neonatal outcomes according to the embryo culture conditions evaluated in this review. Further research is needed about the safety of IVF culture conditions as far as future children’s health is concerned.</description><subject>Birth Weight</subject><subject>Child</subject><subject>Culture Media</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Gestational age</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>In vitro fertilization</subject><subject>Infant, Newborn</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Neonates</subject><subject>Oxygen</subject><subject>Oxygen tension</subject><subject>Pregnancy</subject><subject>Premature Birth</subject><subject>Reproductive Medicine</subject><subject>Review</subject><subject>Reviews</subject><issn>1058-0468</issn><issn>1573-7330</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctOHTEMhiNUxOXAC3RRReqmmxQnmcxlVSEoLRISG2A78iQeOmhmcppkqM7bEzi0lViwsS3582_LP2MfJXyVANVJlFBLI0AVAjQoELDDDqSptKi0hg-5BlMLKMp6nx3G-AAATa30HtvXtSrKRqkD5s49v7y74HYZ0xKIWz-7IQ1-jvwXPhLHmQ_TGm3ifuYz-RkTjtwvyfqJ4jd-yuMmJpowDZYHehzoT55xfKKEAmccN3GIR2y3xzHS8WtesduL7zdnP8XV9Y_Ls9MrYXVlknBdZ4xrCovSYdVbsrW0iArKXjplDdmCqHPQlb0FR1KTkr20rqama9B1esW-bHXXwf9eKKZ2GqKlccR8-RJb1cjKGFMUKqOf36APfgn53meq0vlVsikzpbaUDT7GQH27DsOEYdNKaJ89aLcetNmD9sWDHFfs06v00k3k_o38fXoG9BaIuTXfU_i_-x3ZJ8qjk3o</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Sonigo, Charlotte</creator><creator>Ahdad-Yata, Naouel</creator><creator>Pirtea, Paul</creator><creator>Solignac, Céline</creator><creator>Grynberg, Michael</creator><creator>Sermondade, Nathalie</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7044-6935</orcidid></search><sort><creationdate>20240301</creationdate><title>Do IVF culture conditions have an impact on neonatal outcomes? A systematic review and meta-analysis</title><author>Sonigo, Charlotte ; Ahdad-Yata, Naouel ; Pirtea, Paul ; Solignac, Céline ; Grynberg, Michael ; Sermondade, Nathalie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-dbb55d94ca1da7fcec81caa206f1d2c5ec4eebd0b6fc0de13e21f1cd8e9b9adb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Birth Weight</topic><topic>Child</topic><topic>Culture Media</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Gestational age</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>In vitro fertilization</topic><topic>Infant, Newborn</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Neonates</topic><topic>Oxygen</topic><topic>Oxygen tension</topic><topic>Pregnancy</topic><topic>Premature Birth</topic><topic>Reproductive Medicine</topic><topic>Review</topic><topic>Reviews</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sonigo, Charlotte</creatorcontrib><creatorcontrib>Ahdad-Yata, Naouel</creatorcontrib><creatorcontrib>Pirtea, Paul</creatorcontrib><creatorcontrib>Solignac, Céline</creatorcontrib><creatorcontrib>Grynberg, Michael</creatorcontrib><creatorcontrib>Sermondade, Nathalie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sonigo, Charlotte</au><au>Ahdad-Yata, Naouel</au><au>Pirtea, Paul</au><au>Solignac, Céline</au><au>Grynberg, Michael</au><au>Sermondade, Nathalie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do IVF culture conditions have an impact on neonatal outcomes? A systematic review and meta-analysis</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>41</volume><issue>3</issue><spage>563</spage><epage>580</epage><pages>563-580</pages><issn>1058-0468</issn><issn>1573-7330</issn><eissn>1573-7330</eissn><abstract>Purpose
Are embryo culture conditions, including type of incubator, oxygen tension, and culture media, associated with obstetric or neonatal complications following in vitro fertilization (IVF)?
Methods
A systematic search of MEDLINE, EMBASE, and Cochrane Library was performed from January 01, 2008, until October 31, 2021. The studies reporting quantitative data on at least one of the primary outcomes (birthweight and preterm birth) for the exposure group and the control group were included. For oxygen tension, independent meta-analysis was performed using Review Manager, comparing hypoxia/normoxia. For culture media, a network meta-analysis was carried out using R software, allowing the inclusion of articles comparing two or more culture media.
Results
After reviewing 182 records, 39 full-text articles were assessed for eligibility. A total of 28 studies were kept for review. Meta-analysis about the impact of incubator type on perinatal outcomes could not be carried out because of a limited number of studies. For oxygen tension, three studies were included. The pairwise meta-analysis comparing hypoxia/normoxia did not show any statistical difference for birthweight and gestational age at birth. For culture media, 18 studies were included. The network meta-analysis failed to reveal any significant impact of different culture media on birthweight or preterm birth.
Conclusion
No difference was observed for neonatal outcomes according to the embryo culture conditions evaluated in this review. Further research is needed about the safety of IVF culture conditions as far as future children’s health is concerned.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38246922</pmid><doi>10.1007/s10815-024-03020-0</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-7044-6935</orcidid></addata></record> |
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| ispartof | Journal of assisted reproduction and genetics, 2024-03, Vol.41 (3), p.563-580 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Birth Weight Child Culture Media Female Fertilization in Vitro Gestational age Gynecology Human Genetics Humans Hypoxia In vitro fertilization Infant, Newborn Medicine Medicine & Public Health Meta-analysis Neonates Oxygen Oxygen tension Pregnancy Premature Birth Reproductive Medicine Review Reviews |
| title | Do IVF culture conditions have an impact on neonatal outcomes? A systematic review and meta-analysis |
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