Transitioning from static to suspension culture system for large‐scale production of xeno‐free extracellular vesicles derived from mesenchymal stromal cells

Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) have shown increasing therapeutic potential in the last years. However, large production of EV is required for therapeutic purposes. Thereby, scaling up MSC cultivation in bioreactors is essential to allow culture parameters...

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Veröffentlicht in:	Biotechnology progress 2024-05, Vol.40 (3), p.e3419-n/a
Hauptverfasser:	Santos, Natália Cristine Dias, Bruzadelle‐Vieira, Paula, Cássia Noronha, Nádia, Mizukami‐Martins, Amanda, Orellana, Maristela Delgado, Bentley, Maria Vitória L. B., Covas, Dimas Tadeu, Swiech, Kamilla, Malmegrim, Kelen Cristina Ribeiro
Format:	Artikel
Sprache:	eng
Schlagworte:	bioprocess Bioreactors CD63 antigen CD81 antigen CD9 antigen Cell culture Culture Extracellular vesicles Flasks Mesenchymal stem cells mesenchymal stromal cells Nanoparticles Protozoa Scaling up static culture Stromal cells Suspension culture Therapeutic applications Vesicles Western blotting
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