Respiratory oscillometry testing in relation to exercise in healthy and asthmatic Thoroughbreds
Background Racehorses may experience exercise‐induced bronchodilation or bronchoconstriction, with potential differences between healthy and asthmatic individuals. Objectives To identify exercise‐related lung function variations by oscillometry in racehorses, compare lung function between healthy an...
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| Veröffentlicht in: | Equine veterinary journal 2025-01, Vol.57 (1), p.28-37 |
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| creator | Lo Feudo, Chiara Maria Stucchi, Luca Bizzotto, Davide Dellacà, Raffaele Lavoie, Jean‐Pierre Ferrucci, Francesco |
| description | Background
Racehorses may experience exercise‐induced bronchodilation or bronchoconstriction, with potential differences between healthy and asthmatic individuals.
Objectives
To identify exercise‐related lung function variations by oscillometry in racehorses, compare lung function between healthy and mild equine asthma (MEA) horses, assess oscillometry's potential as a predictor of racing fitness.
Study design
Prospective case–control clinical study.
Methods
Fourteen Thoroughbred racehorses (5 healthy, 9 MEA) underwent a protocol including respiratory oscillometry at rest, exercise with fitness monitoring, oscillometry at 15 and 45 min post‐exercise, and bronchoalveolar lavage fluid (BALf) cytology. Oscillometry parameters (resistance [Rrs] and reactance [Xrs]) were compared within and between healthy and MEA groups at different timepoints. Associations between Rrs and Xrs at rest and 15 min post‐exercise and BALf cytology and fitness indices were evaluated.
Results
MEA horses showed higher Rrs at 15 min post‐exercise (0.6 ± 0.2 cmH2O/L/s) than healthy horses (0.3 ± 0.1 cmH2O/L/s) (p |
| doi_str_mv | 10.1111/evj.14065 |
| format | Article |
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Racehorses may experience exercise‐induced bronchodilation or bronchoconstriction, with potential differences between healthy and asthmatic individuals.
Objectives
To identify exercise‐related lung function variations by oscillometry in racehorses, compare lung function between healthy and mild equine asthma (MEA) horses, assess oscillometry's potential as a predictor of racing fitness.
Study design
Prospective case–control clinical study.
Methods
Fourteen Thoroughbred racehorses (5 healthy, 9 MEA) underwent a protocol including respiratory oscillometry at rest, exercise with fitness monitoring, oscillometry at 15 and 45 min post‐exercise, and bronchoalveolar lavage fluid (BALf) cytology. Oscillometry parameters (resistance [Rrs] and reactance [Xrs]) were compared within and between healthy and MEA groups at different timepoints. Associations between Rrs and Xrs at rest and 15 min post‐exercise and BALf cytology and fitness indices were evaluated.
Results
MEA horses showed higher Rrs at 15 min post‐exercise (0.6 ± 0.2 cmH2O/L/s) than healthy horses (0.3 ± 0.1 cmH2O/L/s) (p < 0.01). In healthy horses, Rrs decreased at 15 min post‐exercise compared with resting values (0.5 ± 0.1 cmH2O/L/s) (p = 0.04). In MEA horses, oscillometry parameters did not vary with time. Post‐exercise Xrs inversely correlated with total haemosiderin score (p < 0.01, r2 = 0.51). Resting Rrs inversely correlated with speed at 200 bpm (p = 0.03, r2 = −0.61), and Xrs with maximum heart rate (HR) during exercise (p = 0.02, r2 = −0.62). Post‐exercise Rrs inversely correlated with mean (p = 0.04, r2 = −0.60) and maximum speed (p = 0.04, r2 = −0.60), and HR variability (p < 0.01, r2 = −0.74).
Main limitations
Small sample size, oscillometry repeatability not assessed, potential interference of upper airway obstructions, external variables influencing fitness indices.
Conclusions
Oscillometry identified lung function differences between healthy and MEA horses at 15 min post‐exercise. Only healthy horses exhibited exercise‐induced bronchodilation. Oscillometry showed potential in predicting subclinical airway obstruction.</description><identifier>ISSN: 0425-1644</identifier><identifier>ISSN: 2042-3306</identifier><identifier>EISSN: 2042-3306</identifier><identifier>DOI: 10.1111/evj.14065</identifier><identifier>PMID: 38247256</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Airway management ; Animals ; Asthma ; Asthma - diagnosis ; Asthma - physiopathology ; Asthma - veterinary ; Bronchoalveolar Lavage Fluid - cytology ; Case-Control Studies ; Cellular biology ; equine asthma ; Female ; horse ; Horse Diseases - diagnosis ; Horse Diseases - physiopathology ; Horses ; Horses - physiology ; lung function ; Male ; oscillometry ; Oscillometry - veterinary ; Physical Conditioning, Animal ; Physical fitness ; Prospective Studies ; racehorses ; Respiratory Function Tests - veterinary ; Thoroughbred</subject><ispartof>Equine veterinary journal, 2025-01, Vol.57 (1), p.28-37</ispartof><rights>2024 EVJ Ltd.</rights><rights>2025 EVJ Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-ced6461d848f0281028ef6ad4b1fcc8fa5c926aa3b2c6840ec5b9bbd1a27e7d13</citedby><cites>FETCH-LOGICAL-c3535-ced6461d848f0281028ef6ad4b1fcc8fa5c926aa3b2c6840ec5b9bbd1a27e7d13</cites><orcidid>0000-0003-4655-2102 ; 0000-0002-9964-2753</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fevj.14065$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fevj.14065$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38247256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lo Feudo, Chiara Maria</creatorcontrib><creatorcontrib>Stucchi, Luca</creatorcontrib><creatorcontrib>Bizzotto, Davide</creatorcontrib><creatorcontrib>Dellacà, Raffaele</creatorcontrib><creatorcontrib>Lavoie, Jean‐Pierre</creatorcontrib><creatorcontrib>Ferrucci, Francesco</creatorcontrib><title>Respiratory oscillometry testing in relation to exercise in healthy and asthmatic Thoroughbreds</title><title>Equine veterinary journal</title><addtitle>Equine Vet J</addtitle><description>Background
Racehorses may experience exercise‐induced bronchodilation or bronchoconstriction, with potential differences between healthy and asthmatic individuals.
Objectives
To identify exercise‐related lung function variations by oscillometry in racehorses, compare lung function between healthy and mild equine asthma (MEA) horses, assess oscillometry's potential as a predictor of racing fitness.
Study design
Prospective case–control clinical study.
Methods
Fourteen Thoroughbred racehorses (5 healthy, 9 MEA) underwent a protocol including respiratory oscillometry at rest, exercise with fitness monitoring, oscillometry at 15 and 45 min post‐exercise, and bronchoalveolar lavage fluid (BALf) cytology. Oscillometry parameters (resistance [Rrs] and reactance [Xrs]) were compared within and between healthy and MEA groups at different timepoints. Associations between Rrs and Xrs at rest and 15 min post‐exercise and BALf cytology and fitness indices were evaluated.
Results
MEA horses showed higher Rrs at 15 min post‐exercise (0.6 ± 0.2 cmH2O/L/s) than healthy horses (0.3 ± 0.1 cmH2O/L/s) (p < 0.01). In healthy horses, Rrs decreased at 15 min post‐exercise compared with resting values (0.5 ± 0.1 cmH2O/L/s) (p = 0.04). In MEA horses, oscillometry parameters did not vary with time. Post‐exercise Xrs inversely correlated with total haemosiderin score (p < 0.01, r2 = 0.51). Resting Rrs inversely correlated with speed at 200 bpm (p = 0.03, r2 = −0.61), and Xrs with maximum heart rate (HR) during exercise (p = 0.02, r2 = −0.62). Post‐exercise Rrs inversely correlated with mean (p = 0.04, r2 = −0.60) and maximum speed (p = 0.04, r2 = −0.60), and HR variability (p < 0.01, r2 = −0.74).
Main limitations
Small sample size, oscillometry repeatability not assessed, potential interference of upper airway obstructions, external variables influencing fitness indices.
Conclusions
Oscillometry identified lung function differences between healthy and MEA horses at 15 min post‐exercise. Only healthy horses exhibited exercise‐induced bronchodilation. Oscillometry showed potential in predicting subclinical airway obstruction.</description><subject>Airway management</subject><subject>Animals</subject><subject>Asthma</subject><subject>Asthma - diagnosis</subject><subject>Asthma - physiopathology</subject><subject>Asthma - veterinary</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Case-Control Studies</subject><subject>Cellular biology</subject><subject>equine asthma</subject><subject>Female</subject><subject>horse</subject><subject>Horse Diseases - diagnosis</subject><subject>Horse Diseases - physiopathology</subject><subject>Horses</subject><subject>Horses - physiology</subject><subject>lung function</subject><subject>Male</subject><subject>oscillometry</subject><subject>Oscillometry - veterinary</subject><subject>Physical Conditioning, Animal</subject><subject>Physical fitness</subject><subject>Prospective Studies</subject><subject>racehorses</subject><subject>Respiratory Function Tests - veterinary</subject><subject>Thoroughbred</subject><issn>0425-1644</issn><issn>2042-3306</issn><issn>2042-3306</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1LwzAUhoMobk4v_ANS8EYv6vK97lLG_GIgiHob0vTUZrTNTFp1_97opheCB8JJwsPLy4PQMcEXJM4Y3pYXhGMpdtCQYk5TxrDcRcN4FSmRnA_QQQhLjBmjnO6jAcson1Ahh0g9QFhZrzvn14kLxta1a6CLjw5CZ9uXxLaJh1p31rVJ5xL4AG9sgK__CnTdVetEt0WiQ1c1kTLJY-W861-q3EMRDtFeqesAR9s9Qk9X88fZTbq4v76dXS5SwwQTqYFCckmKjGclphmJB0qpC56T0pis1MJMqdSa5dTIjGMwIp_meUE0ncCkIGyEzja5K-9e-1hdNTYYqGvdguuDolMyEYKLjEf09A-6dL1vYzvFokUuppzJSJ1vKONdCB5KtfK20X6tCFZf1lW0rr6tR_Zkm9jnDRS_5I_mCIw3wLutYf1_kpo_320iPwFpTY06</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Lo Feudo, Chiara Maria</creator><creator>Stucchi, Luca</creator><creator>Bizzotto, Davide</creator><creator>Dellacà, Raffaele</creator><creator>Lavoie, Jean‐Pierre</creator><creator>Ferrucci, Francesco</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4655-2102</orcidid><orcidid>https://orcid.org/0000-0002-9964-2753</orcidid></search><sort><creationdate>202501</creationdate><title>Respiratory oscillometry testing in relation to exercise in healthy and asthmatic Thoroughbreds</title><author>Lo Feudo, Chiara Maria ; Stucchi, Luca ; Bizzotto, Davide ; Dellacà, Raffaele ; Lavoie, Jean‐Pierre ; Ferrucci, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-ced6461d848f0281028ef6ad4b1fcc8fa5c926aa3b2c6840ec5b9bbd1a27e7d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Airway management</topic><topic>Animals</topic><topic>Asthma</topic><topic>Asthma - diagnosis</topic><topic>Asthma - physiopathology</topic><topic>Asthma - veterinary</topic><topic>Bronchoalveolar Lavage Fluid - cytology</topic><topic>Case-Control Studies</topic><topic>Cellular biology</topic><topic>equine asthma</topic><topic>Female</topic><topic>horse</topic><topic>Horse Diseases - diagnosis</topic><topic>Horse Diseases - physiopathology</topic><topic>Horses</topic><topic>Horses - physiology</topic><topic>lung function</topic><topic>Male</topic><topic>oscillometry</topic><topic>Oscillometry - veterinary</topic><topic>Physical Conditioning, Animal</topic><topic>Physical fitness</topic><topic>Prospective Studies</topic><topic>racehorses</topic><topic>Respiratory Function Tests - veterinary</topic><topic>Thoroughbred</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lo Feudo, Chiara Maria</creatorcontrib><creatorcontrib>Stucchi, Luca</creatorcontrib><creatorcontrib>Bizzotto, Davide</creatorcontrib><creatorcontrib>Dellacà, Raffaele</creatorcontrib><creatorcontrib>Lavoie, Jean‐Pierre</creatorcontrib><creatorcontrib>Ferrucci, Francesco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Equine veterinary journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lo Feudo, Chiara Maria</au><au>Stucchi, Luca</au><au>Bizzotto, Davide</au><au>Dellacà, Raffaele</au><au>Lavoie, Jean‐Pierre</au><au>Ferrucci, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Respiratory oscillometry testing in relation to exercise in healthy and asthmatic Thoroughbreds</atitle><jtitle>Equine veterinary journal</jtitle><addtitle>Equine Vet J</addtitle><date>2025-01</date><risdate>2025</risdate><volume>57</volume><issue>1</issue><spage>28</spage><epage>37</epage><pages>28-37</pages><issn>0425-1644</issn><issn>2042-3306</issn><eissn>2042-3306</eissn><abstract>Background
Racehorses may experience exercise‐induced bronchodilation or bronchoconstriction, with potential differences between healthy and asthmatic individuals.
Objectives
To identify exercise‐related lung function variations by oscillometry in racehorses, compare lung function between healthy and mild equine asthma (MEA) horses, assess oscillometry's potential as a predictor of racing fitness.
Study design
Prospective case–control clinical study.
Methods
Fourteen Thoroughbred racehorses (5 healthy, 9 MEA) underwent a protocol including respiratory oscillometry at rest, exercise with fitness monitoring, oscillometry at 15 and 45 min post‐exercise, and bronchoalveolar lavage fluid (BALf) cytology. Oscillometry parameters (resistance [Rrs] and reactance [Xrs]) were compared within and between healthy and MEA groups at different timepoints. Associations between Rrs and Xrs at rest and 15 min post‐exercise and BALf cytology and fitness indices were evaluated.
Results
MEA horses showed higher Rrs at 15 min post‐exercise (0.6 ± 0.2 cmH2O/L/s) than healthy horses (0.3 ± 0.1 cmH2O/L/s) (p < 0.01). In healthy horses, Rrs decreased at 15 min post‐exercise compared with resting values (0.5 ± 0.1 cmH2O/L/s) (p = 0.04). In MEA horses, oscillometry parameters did not vary with time. Post‐exercise Xrs inversely correlated with total haemosiderin score (p < 0.01, r2 = 0.51). Resting Rrs inversely correlated with speed at 200 bpm (p = 0.03, r2 = −0.61), and Xrs with maximum heart rate (HR) during exercise (p = 0.02, r2 = −0.62). Post‐exercise Rrs inversely correlated with mean (p = 0.04, r2 = −0.60) and maximum speed (p = 0.04, r2 = −0.60), and HR variability (p < 0.01, r2 = −0.74).
Main limitations
Small sample size, oscillometry repeatability not assessed, potential interference of upper airway obstructions, external variables influencing fitness indices.
Conclusions
Oscillometry identified lung function differences between healthy and MEA horses at 15 min post‐exercise. Only healthy horses exhibited exercise‐induced bronchodilation. Oscillometry showed potential in predicting subclinical airway obstruction.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38247256</pmid><doi>10.1111/evj.14065</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4655-2102</orcidid><orcidid>https://orcid.org/0000-0002-9964-2753</orcidid></addata></record> |
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| subjects | Airway management Animals Asthma Asthma - diagnosis Asthma - physiopathology Asthma - veterinary Bronchoalveolar Lavage Fluid - cytology Case-Control Studies Cellular biology equine asthma Female horse Horse Diseases - diagnosis Horse Diseases - physiopathology Horses Horses - physiology lung function Male oscillometry Oscillometry - veterinary Physical Conditioning, Animal Physical fitness Prospective Studies racehorses Respiratory Function Tests - veterinary Thoroughbred |
| title | Respiratory oscillometry testing in relation to exercise in healthy and asthmatic Thoroughbreds |
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