Synthesis of Chiral α‑Aryl Ketones by Photoredox/Nickel-Catalyzed Enantioconvergent Acyl Cross-Coupling with Organotrifluoroborate

Synthesis of Chiral α‑Aryl Ketones by Photoredox/Nickel-Catalyzed Enantioconvergent Acyl Cross-Coupling with Organotrifluoroborate

Photoredox/nickel-catalyzed enantioconvergent acyl cross-coupling of carboxylic derivatives with racemic secondary organotrifluoroborate was developed for the synthesis of an enolizable chiral α-aryl ketone under mild neutral conditions. Moderate to high yields and good enantioselectivities were ach...

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Veröffentlicht in:Organic letters 2024-02, Vol.26 (4), p.850-854
Hauptverfasser: Wang, Weichen, Shen, Chaoren, Zhang, Linli, Dong, Kaiwu
Format: Artikel
Sprache:eng
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Zusammenfassung:Photoredox/nickel-catalyzed enantioconvergent acyl cross-coupling of carboxylic derivatives with racemic secondary organotrifluoroborate was developed for the synthesis of an enolizable chiral α-aryl ketone under mild neutral conditions. Moderate to high yields and good enantioselectivities were achieved.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c04004