Triptolide induces apoptosis and cytoprotective autophagy by ROS accumulation via directly targeting peroxiredoxin 2 in gastric cancer cells

Triptolide, a natural bioactive compound derived from herbal medicine Tripterygium wilfordii, has multiple biological activities including anti-cancer effect, which is being tested in clinical trials for treating cancers. However, the exact mechanism by which Triptolide exerts its cytotoxic effects,...

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Veröffentlicht in:	Cancer letters 2024-04, Vol.587, p.216622-216622, Article 216622
Hauptverfasser:	Chen, Pengchen, Zhong, Xiaoru, Song, Yali, Zhong, Wenbin, Wang, Sisi, Wang, Jinyan, Huang, Pan, Niu, Yaping, Yang, Wenyue, Ding, Ziyang, Luo, Qingming, Yang, Chuanbin, Wang, Jigang, Zhang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Endoplasmic reticulum stress Gastric cancer Peroxiredoxin-2 Triptolide
Online-Zugang:	Volltext
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