Acute suppression of translation by hyperthermia enhances anti-myeloma activity of carfilzomib

Hyperthermia is a unique treatment option for cancers. Multiple myeloma (MM) remains incurable and innovative therapeutic options are needed. We investigated the efficacy of hyperthermia and carfilzomib in combination against MM cells. Although MM cell lines exhibited different susceptibilities to p...

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Veröffentlicht in:	International journal of hematology 2024-03, Vol.119 (3), p.291-302
Hauptverfasser:	Maruhashi, Tomoko, Miki, Hirokazu, Sogabe, Kimiko, Oda, Asuka, Sumitani, Ryohei, Oura, Masahiro, Takahashi, Mamiko, Harada, Takeshi, Fujii, Shiro, Nakamura, Shingen, Kurahashi, Kiyoe, Endo, Itsuro, Abe, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell death Drug resistance Enzymatic activity Fever Heat recovery Heat treatment Heat treatments Hematology Humans Hyperthermia Hyperthermia, Induced Inhibitor drugs Medical innovations Medicine Medicine & Public Health Multiple myeloma Multiple Myeloma - drug therapy Oligopeptides - pharmacology Oligopeptides - therapeutic use Oncology Original Article Phosphorylation Plasmacytoma Proteasomes Targeted cancer therapy Translation
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