Nanosilver-Functionalized Hybrid Hydrogels of Carboxymethyl Cellulose/Poly(Vinyl Alcohol) with Antibacterial Activity for Prevention and Therapy of Infections of Diabetic Chronic Wounds
Diabetic foot ulcers (DFUs) are considered one of the most severe chronic complications of diabetes and can lead to amputation in severe cases. In addition, bacterial infections in diabetic chronic wounds aggravate this scenario by threatening human health. Wound dressings made of polymer matrices w...
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| Veröffentlicht in: | Polymers 2023-11, Vol.15 (23), p.4542 |
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| creator | Capanema, Nádia S V Mansur, Alexandra A P Carvalho, Sandhra M Martins, Talita Gonçalves, Maysa S Andrade, Rafaella S Dorneles, Elaine M S Lima, Letícia C D de Alvarenga, Érika L F C da Fonseca, Emanuel V B Sá, Marcos Augusto de Lage, Andrey P Lobato, Zelia I P Mansur, Herman S |
| description | Diabetic foot ulcers (DFUs) are considered one of the most severe chronic complications of diabetes and can lead to amputation in severe cases. In addition, bacterial infections in diabetic chronic wounds aggravate this scenario by threatening human health. Wound dressings made of polymer matrices with embedded metal nanoparticles can inhibit microorganism growth and promote wound healing, although the current clinical treatments for diabetic chronic wounds remain unsatisfactory. In this view, this research reports the synthesis and characterization of innovative hybrid hydrogels made of carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) chemically crosslinked by citric acid (CA) functionalized with silver nanoparticles (AgNPs) generated in situ using an eco-friendly aqueous process. The results assessed through comprehensive in vitro and in vivo assays demonstrated that these hybrid polymer hydrogels functionalized with AgNPs possess physicochemical properties, cytocompatibility, hemocompatibility, bioadhesion, antibacterial activity, and biocompatibility suitable for wound dressings to support chronic wound healing process as well as preventing and treating bacterial infections. Hence, it can be envisioned that, with further research and development, these polymer-based hybrid nanoplatforms hold great potential as an important tool for creating a new generation of smart dressings for treating chronic diabetic wounds and opportunistic bacterial infections. |
| doi_str_mv | 10.3390/polym15234542 |
| format | Article |
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In addition, bacterial infections in diabetic chronic wounds aggravate this scenario by threatening human health. Wound dressings made of polymer matrices with embedded metal nanoparticles can inhibit microorganism growth and promote wound healing, although the current clinical treatments for diabetic chronic wounds remain unsatisfactory. In this view, this research reports the synthesis and characterization of innovative hybrid hydrogels made of carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) chemically crosslinked by citric acid (CA) functionalized with silver nanoparticles (AgNPs) generated in situ using an eco-friendly aqueous process. The results assessed through comprehensive in vitro and in vivo assays demonstrated that these hybrid polymer hydrogels functionalized with AgNPs possess physicochemical properties, cytocompatibility, hemocompatibility, bioadhesion, antibacterial activity, and biocompatibility suitable for wound dressings to support chronic wound healing process as well as preventing and treating bacterial infections. Hence, it can be envisioned that, with further research and development, these polymer-based hybrid nanoplatforms hold great potential as an important tool for creating a new generation of smart dressings for treating chronic diabetic wounds and opportunistic bacterial infections.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym15234542</identifier><identifier>PMID: 38231902</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antibacterial agents ; Antibiotics ; Bacteria ; Bacterial infections ; Biocompatibility ; Biopolymers ; Carboxymethyl cellulose ; Care and treatment ; Cellulose ; Chemical properties ; Chronic illnesses ; Citric acid ; Composite materials ; Debridement ; Diabetes ; Diabetic foot ; Drug resistance ; Foot diseases ; Gram-positive bacteria ; Health aspects ; Hydrogels ; Hyperglycemia ; Infection ; Infections ; Microorganisms ; Nanoparticles ; Polymers ; Polyvinyl alcohol ; R&D ; Research & development ; Silver ; Skin ; Tissue engineering ; Type 2 diabetes ; Ulcers ; Wound healing ; Wounds and injuries</subject><ispartof>Polymers, 2023-11, Vol.15 (23), p.4542</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-4f1bdb49962b379a52333adfbe58e539f28ad9d35a3c79d17fa8510c216992163</citedby><cites>FETCH-LOGICAL-c427t-4f1bdb49962b379a52333adfbe58e539f28ad9d35a3c79d17fa8510c216992163</cites><orcidid>0000-0002-0195-7926 ; 0000-0002-3032-495X ; 0000-0001-7810-8511 ; 0000-0002-9480-9761</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38231902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Capanema, Nádia S V</creatorcontrib><creatorcontrib>Mansur, Alexandra A P</creatorcontrib><creatorcontrib>Carvalho, Sandhra M</creatorcontrib><creatorcontrib>Martins, Talita</creatorcontrib><creatorcontrib>Gonçalves, Maysa S</creatorcontrib><creatorcontrib>Andrade, Rafaella S</creatorcontrib><creatorcontrib>Dorneles, Elaine M S</creatorcontrib><creatorcontrib>Lima, Letícia C D</creatorcontrib><creatorcontrib>de Alvarenga, Érika L F C</creatorcontrib><creatorcontrib>da Fonseca, Emanuel V B</creatorcontrib><creatorcontrib>Sá, Marcos Augusto de</creatorcontrib><creatorcontrib>Lage, Andrey P</creatorcontrib><creatorcontrib>Lobato, Zelia I P</creatorcontrib><creatorcontrib>Mansur, Herman S</creatorcontrib><title>Nanosilver-Functionalized Hybrid Hydrogels of Carboxymethyl Cellulose/Poly(Vinyl Alcohol) with Antibacterial Activity for Prevention and Therapy of Infections of Diabetic Chronic Wounds</title><title>Polymers</title><addtitle>Polymers (Basel)</addtitle><description>Diabetic foot ulcers (DFUs) are considered one of the most severe chronic complications of diabetes and can lead to amputation in severe cases. 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The results assessed through comprehensive in vitro and in vivo assays demonstrated that these hybrid polymer hydrogels functionalized with AgNPs possess physicochemical properties, cytocompatibility, hemocompatibility, bioadhesion, antibacterial activity, and biocompatibility suitable for wound dressings to support chronic wound healing process as well as preventing and treating bacterial infections. Hence, it can be envisioned that, with further research and development, these polymer-based hybrid nanoplatforms hold great potential as an important tool for creating a new generation of smart dressings for treating chronic diabetic wounds and opportunistic bacterial infections.</description><subject>Antibacterial agents</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Biocompatibility</subject><subject>Biopolymers</subject><subject>Carboxymethyl cellulose</subject><subject>Care and treatment</subject><subject>Cellulose</subject><subject>Chemical properties</subject><subject>Chronic illnesses</subject><subject>Citric acid</subject><subject>Composite materials</subject><subject>Debridement</subject><subject>Diabetes</subject><subject>Diabetic foot</subject><subject>Drug resistance</subject><subject>Foot diseases</subject><subject>Gram-positive bacteria</subject><subject>Health aspects</subject><subject>Hydrogels</subject><subject>Hyperglycemia</subject><subject>Infection</subject><subject>Infections</subject><subject>Microorganisms</subject><subject>Nanoparticles</subject><subject>Polymers</subject><subject>Polyvinyl alcohol</subject><subject>R&D</subject><subject>Research & development</subject><subject>Silver</subject><subject>Skin</subject><subject>Tissue engineering</subject><subject>Type 2 diabetes</subject><subject>Ulcers</subject><subject>Wound healing</subject><subject>Wounds and injuries</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkktvFSEUxydGY5vapVtD4qYuph1gXixvptY2abSLqssJA4cODQNXYK6O38xvJ9PWR42Q8CeH33lwcrLsJS6OKWXFydaZZcIVoWVVkifZPikampe0Lp7-dd_LDkO4LdIqq7rGzfNsj7aEYlaQ_ezHe25d0GYHPj-brYjaWW70d5DofBm8XkV6dwMmIKdQx_3gvi0TxHExqANjZuMCnFylQo4-aZuMGyPc6Mwb9FXHEW1s1AMXEbzm6S3F3-m4IOU8uvKwA7smRNxKdD2C59tlzXJhFdxVcpfzVPMBohaoG72zST-72crwInumuAlw-KAH2cezt9fdeX754d1Ft7nMRUmamJcKD3IoGavJQBvGU7Mo5VINULVQUaZIyyWTtOJUNEziRvG2woUguGYsHfQgO7qPu_Xuywwh9pMOIv2cW3Bz6AnDdVmwpq4S-vof9NbNPvUzUS1jJSW0pn-oG26g11a56LlYg_abpqlahhlliTr-D5W2hEkLZ0HpZH_kkN87CO9C8KD6rdcT90uPi36dlv7RtCT-1UOx8zCB_E3_mg36E9R0vQM</recordid><startdate>20231127</startdate><enddate>20231127</enddate><creator>Capanema, Nádia S V</creator><creator>Mansur, Alexandra A P</creator><creator>Carvalho, Sandhra M</creator><creator>Martins, Talita</creator><creator>Gonçalves, Maysa S</creator><creator>Andrade, Rafaella S</creator><creator>Dorneles, Elaine M S</creator><creator>Lima, Letícia C D</creator><creator>de Alvarenga, Érika L F C</creator><creator>da Fonseca, Emanuel V B</creator><creator>Sá, Marcos Augusto de</creator><creator>Lage, Andrey P</creator><creator>Lobato, Zelia I P</creator><creator>Mansur, Herman S</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0195-7926</orcidid><orcidid>https://orcid.org/0000-0002-3032-495X</orcidid><orcidid>https://orcid.org/0000-0001-7810-8511</orcidid><orcidid>https://orcid.org/0000-0002-9480-9761</orcidid></search><sort><creationdate>20231127</creationdate><title>Nanosilver-Functionalized Hybrid Hydrogels of Carboxymethyl Cellulose/Poly(Vinyl Alcohol) with Antibacterial Activity for Prevention and Therapy of Infections of Diabetic Chronic Wounds</title><author>Capanema, Nádia S V ; 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In addition, bacterial infections in diabetic chronic wounds aggravate this scenario by threatening human health. Wound dressings made of polymer matrices with embedded metal nanoparticles can inhibit microorganism growth and promote wound healing, although the current clinical treatments for diabetic chronic wounds remain unsatisfactory. In this view, this research reports the synthesis and characterization of innovative hybrid hydrogels made of carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) chemically crosslinked by citric acid (CA) functionalized with silver nanoparticles (AgNPs) generated in situ using an eco-friendly aqueous process. The results assessed through comprehensive in vitro and in vivo assays demonstrated that these hybrid polymer hydrogels functionalized with AgNPs possess physicochemical properties, cytocompatibility, hemocompatibility, bioadhesion, antibacterial activity, and biocompatibility suitable for wound dressings to support chronic wound healing process as well as preventing and treating bacterial infections. 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| ispartof | Polymers, 2023-11, Vol.15 (23), p.4542 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Antibacterial agents Antibiotics Bacteria Bacterial infections Biocompatibility Biopolymers Carboxymethyl cellulose Care and treatment Cellulose Chemical properties Chronic illnesses Citric acid Composite materials Debridement Diabetes Diabetic foot Drug resistance Foot diseases Gram-positive bacteria Health aspects Hydrogels Hyperglycemia Infection Infections Microorganisms Nanoparticles Polymers Polyvinyl alcohol R&D Research & development Silver Skin Tissue engineering Type 2 diabetes Ulcers Wound healing Wounds and injuries |
| title | Nanosilver-Functionalized Hybrid Hydrogels of Carboxymethyl Cellulose/Poly(Vinyl Alcohol) with Antibacterial Activity for Prevention and Therapy of Infections of Diabetic Chronic Wounds |
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