Mass Spectrometry Evidence for Forming Schiff Base 3′-DNA-Histone Cross-Links from Abasic Sites in Vitro and in Human Cells

Histones catalyze DNA strand incision at apurinic/apyrimidinic (AP) sites accompanied by the formation of reversible but long-lived DNA–protein cross-links at 3′-termini (3′-histone-DPCs). However, the chemical structures of 3′-histone-DPCs are not well characterized, and whether they are formed in...

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Veröffentlicht in:	Chemical research in toxicology 2024-02, Vol.37 (2), p.216-219
Hauptverfasser:	Peng, Ying, Bryan, Cameron, Yang, Kun
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemistry DNA Damage DNA Repair Histones - metabolism Humans Schiff Bases - chemistry Tandem Mass Spectrometry
Online-Zugang:	Volltext
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