Design, Synthesis, and Biological Evaluation of Hydrophobic-Tagged Glutathione Peroxidase 4 (GPX4) Degraders

[Display omitted] •A class of hydrophobically tagged molecules as the first examples of HyT-based GPX4 degraders were identified.•7b effectively induces dose- and time-dependent degradation of GPX4 protein with a DC50 value of 58 nM.•7b degrades GPX4 through both the ubiquitin–proteasome and the aut...

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Veröffentlicht in:	Bioorganic chemistry 2024-03, Vol.144, p.107115-107115, Article 107115
Hauptverfasser:	Li, Xiaomei, Hu, Mengdie, Zhang, Yanping, Hua, Hui, Sun, Yujie, Xiang, Qiuping, Zhu, Dongsheng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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