SARS-CoV-2 NSP14 governs mutational instability and assists in making new SARS-CoV-2 variants

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the rapidly evolving RNA virus behind the COVID-19 pandemic, has spawned numerous variants since its 2019 emergence. The multifunctional Nonstructural protein 14 (NSP14) enzyme, possessing exonuclease and messenger RNA (mRNA) capping capa...

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Veröffentlicht in:	Computers in biology and medicine 2024-03, Vol.170, p.107899, Article 107899
Hauptverfasser:	Hassan, Sk. Sarif, Bhattacharya, Tanishta, Nawn, Debaleena, Jha, Ishana, Basu, Pallab, Redwan, Elrashdy M., Lundstrom, Kenneth, Barh, Debmalya, Andrade, Bruno Silva, Tambuwala, Murtaza M., Aljabali, Alaa A., Hromić-Jahjefendić, Altijana, Baetas-da-Cruz, Wagner, Serrano-Aroca, Ángel, Uversky, Vladimir N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioengineering Clustering Co-mutations-flow Coronaviruses COVID-19 COVID-19 - genetics Drug resistance Evolution Exonuclease Exoribonucleases - chemistry Exoribonucleases - genetics Exoribonucleases - metabolism Genetic diversity Humans Invariant residues mRNA guanylyltransferase mRNA processing Mutation Mutation - genetics Nonstructural protein 14 (NSP14) Pandemics Pathogenicity Pathogens Phylogeny Physicochemical analysis Post-transcription RdRp Residues Ribonucleic acid RNA RNA viruses SARS-CoV-2 SARS-CoV-2 - genetics SARS-CoV-2 - metabolism Severe acute respiratory syndrome coronavirus 2 Vaccine development Vaccines Viral diseases Viral Nonstructural Proteins - metabolism Virus Replication - genetics Viruses
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