Stem Cells and Their Derivatives: Unlocking the Promising Potential of Minimally Manipulated Cells for In Situ Tissue Engineering

We’ve read with great interest the article by Smolinska et al. entitled “Stem Cells and Their Derivatives: An Implication for the Regeneration of Nonunion Fractures” regarding the recent scientific studies dealing with the treatment of nonunion fractures in clinical and preclinical settings using Me...

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Veröffentlicht in:Cell transplantation 2024-01, Vol.33, p.9636897231221846-9636897231221846
Hauptverfasser: Klabukov, Ilya, Baranovskii, Denis
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description We’ve read with great interest the article by Smolinska et al. entitled “Stem Cells and Their Derivatives: An Implication for the Regeneration of Nonunion Fractures” regarding the recent scientific studies dealing with the treatment of nonunion fractures in clinical and preclinical settings using Mesenchymal Stem Cell (MSC)-based therapeutic techniques. Bone tissue regeneration is a dynamic process that involves the restoration of damaged or lost bone structure and function. Traditional approaches such as autografts and allografts, platelet rich plasma (PRP) treatment and cell therapies, have limitations, including donor site morbidity and immunologic concerns, as well as cell culture and processing requirements. In contrast, the use of minimally manipulated cells that do not require culturing has emerged as a promising alternative that offers several advantages in bone tissue regeneration.
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subjects Allografts
Autografts
Bone and Bones
Bone grafts
Bone growth
Bone Regeneration
Cell culture
Cell therapy
Fractures
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal Stem Cells
Morbidity
Nonunion
Platelet-Rich Plasma
Regeneration
Stem cell transplantation
Stem Cells
Structure-function relationships
Tissue culture
Tissue Engineering
Wound Healing
title Stem Cells and Their Derivatives: Unlocking the Promising Potential of Minimally Manipulated Cells for In Situ Tissue Engineering
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