Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic Naegleria fowleri “Brain-Eating” Amoeba

Current therapy for primary amoebic meningoencephalitis (PAM), a highly lethal brain infection in humans caused by Naegleria fowleri amoeba, is restricted to repurposed drugs with limited efficacy and success. Discovery of an antiamoebic benzylamine scaffold 2 precipitated a medicinal chemistry effo...

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Veröffentlicht in:	ACS medicinal chemistry letters 2024-01, Vol.15 (1), p.87-92
Hauptverfasser:	Pomeroy, Julia M., Khalifa, Muhammad M., Milanes, Jillian E., Palmentiero, Caroline M., Morris, James C., Golden, Jennifer E.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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