Short chain fatty acids inhibit corneal inflammatory responses to TLR ligands via the ocular G-protein coupled receptor 43

Short chain fatty acids (SCFAs) produced by gut microbiota are known to play primary roles in gut homeostasis by immunomodulation partially through G-protein coupled receptors (GPR) 43. Using mouse models of TLR ligand induced keratitis, we investigated whether SCFAs and GPR43 play any regulatory ro...

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Veröffentlicht in:	The ocular surface 2024-04, Vol.32, p.48-57
Hauptverfasser:	Wu, Jun, Chen, Nu, Grau, Elizabeth, Johnson, Luke, Liu, Yongqing, Li, Chi, Scott, Patrick A., Kim, Chang, Sun, Deming, Kaplan, Henry J., Shao, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Butyrate Cytokines and chemokines G-protein coupled receptors (GPR) 43 Microbial induced keratitis Short chain fatty acids TLR ligands
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