C-terminal amino acids in the type I transmembrane domain of L-type lectin VIP36 affect γ-secretase susceptibility

Regulated intramembrane proteolysis (RIP) is a two-step processing mechanism for transmembrane proteins consisting of ectodomain shedding (shedding), which removes the extracellular domain through juxtamembrane processing and intramembrane proteolysis, which processes membrane-anchored shedding prod...

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Veröffentlicht in:	Biochemical and biophysical research communications 2024-02, Vol.696, p.149504-149504, Article 149504
Hauptverfasser:	Hua, Zhihai, Watanabe, Ryoma, Fukunaga, Taku, Matsui, Yojiro, Matsuoka, Mayu, Yamaguchi, Shoya, Tanabe, Shun-ya, Yamamoto, Miyu, Tamura-Kawakami, Keiko, Takagi, Junichi, Kajita, Mihoko, Futai, Eugene, Shirakabe, Kyoko
Format:	Artikel
Sprache:	eng
Schlagworte:	domain Ectodomain shedding (shedding) enzymes hydrophobicity lectins Metalloprotease proteolysis Regulated intramembrane proteolysis (RIP) Transmembrane domain transmembrane proteins γ-secretase
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