Eliminating the need for preoperative intravenous hyperhydration: Sodium thiosulfate as nephrotoxicity prevention in HIPEC-treated patients – A retrospective analysis
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for peritoneal metastases. However, HIPEC with cisplatin is associated with renal toxicity. Sodium thiosulfate (ST) has been shown to prevent cisplatin-induced toxicity. A retrospective, single-cen...
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| Veröffentlicht in: | European journal of surgical oncology 2024-02, Vol.50 (2), p.107955-107955, Article 107955 |
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| creator | Vachez, Elea Kefleyesus, Amaniel Bakrin, Naoual Ranchon, Florence Rioufol, Catherine Vassal, Olivia Al-Hadeedi, Omar Kepenekian, Vahan Glehen, Olivier |
| description | Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for peritoneal metastases. However, HIPEC with cisplatin is associated with renal toxicity. Sodium thiosulfate (ST) has been shown to prevent cisplatin-induced toxicity.
A retrospective, single-center analysis of patients treated curatively for peritoneal surface malignancy, who underwent cytoreductive surgery with cisplatin-based HIPEC between 2015 and 2020. Patients were categorized into three groups based on the management of cisplatin-induced renal toxicity: preoperative hyperhydration alone (PHH), preoperative hyperhydration with ST (PHH + ST), and ST alone. Renal function and complications, in terms of Acute (AKI) and chronic kidney injury (CKI), were monitored and analyzed during 3 postoperative months.
This study included 220 consecutive patients. Mean serum creatinine levels were 95, 57 and 61 mmol/L, for PHH, PHH + ST and ST groups, respectively (p |
| doi_str_mv | 10.1016/j.ejso.2024.107955 |
| format | Article |
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A retrospective, single-center analysis of patients treated curatively for peritoneal surface malignancy, who underwent cytoreductive surgery with cisplatin-based HIPEC between 2015 and 2020. Patients were categorized into three groups based on the management of cisplatin-induced renal toxicity: preoperative hyperhydration alone (PHH), preoperative hyperhydration with ST (PHH + ST), and ST alone. Renal function and complications, in terms of Acute (AKI) and chronic kidney injury (CKI), were monitored and analyzed during 3 postoperative months.
This study included 220 consecutive patients. Mean serum creatinine levels were 95, 57 and 61 mmol/L, for PHH, PHH + ST and ST groups, respectively (p < 0.001). Glomerular Filtration Rate (GFR) were 96, 94 and 78 ml/min/1.73 m2, respectively (p < 0.001). AKI and CKI are respectively for PHH, PHH + ST and ST groups were 21 % (n = 46), 1 % (n = 2) and 0 % vs 19 % (n = 42), 0 % and 0 % (p < 0.001), for pairwise analysis did not show any difference between PHH + ST and ST alone combination, regarding nephrological outcomes. All patients were followed 3 months postoperatively.
There is no need for preoperative hyperhydration when sodium-thiosulfate is used to prevent cisplatin-induced nephrotoxicity in patients undergoing cytoreductive surgery with HIPEC. These findings have implications for improving and simplifying the management of patients with peritoneal metastases undergoing HIPEC with cisplatin.</description><identifier>ISSN: 0748-7983</identifier><identifier>EISSN: 1532-2157</identifier><identifier>DOI: 10.1016/j.ejso.2024.107955</identifier><identifier>PMID: 38219699</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><ispartof>European journal of surgical oncology, 2024-02, Vol.50 (2), p.107955-107955, Article 107955</ispartof><rights>2024 The Authors</rights><rights>2024 Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-9d89e84e27e15b6b74c52e99937a44df216c56a0ea7b4f6577340d602e4cfec23</citedby><cites>FETCH-LOGICAL-c400t-9d89e84e27e15b6b74c52e99937a44df216c56a0ea7b4f6577340d602e4cfec23</cites><orcidid>0000-0001-9885-8600 ; 0000-0002-9181-4231 ; 0000-0002-7951-4041</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejso.2024.107955$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38219699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vachez, Elea</creatorcontrib><creatorcontrib>Kefleyesus, Amaniel</creatorcontrib><creatorcontrib>Bakrin, Naoual</creatorcontrib><creatorcontrib>Ranchon, Florence</creatorcontrib><creatorcontrib>Rioufol, Catherine</creatorcontrib><creatorcontrib>Vassal, Olivia</creatorcontrib><creatorcontrib>Al-Hadeedi, Omar</creatorcontrib><creatorcontrib>Kepenekian, Vahan</creatorcontrib><creatorcontrib>Glehen, Olivier</creatorcontrib><title>Eliminating the need for preoperative intravenous hyperhydration: Sodium thiosulfate as nephrotoxicity prevention in HIPEC-treated patients – A retrospective analysis</title><title>European journal of surgical oncology</title><addtitle>Eur J Surg Oncol</addtitle><description>Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for peritoneal metastases. However, HIPEC with cisplatin is associated with renal toxicity. Sodium thiosulfate (ST) has been shown to prevent cisplatin-induced toxicity.
A retrospective, single-center analysis of patients treated curatively for peritoneal surface malignancy, who underwent cytoreductive surgery with cisplatin-based HIPEC between 2015 and 2020. Patients were categorized into three groups based on the management of cisplatin-induced renal toxicity: preoperative hyperhydration alone (PHH), preoperative hyperhydration with ST (PHH + ST), and ST alone. Renal function and complications, in terms of Acute (AKI) and chronic kidney injury (CKI), were monitored and analyzed during 3 postoperative months.
This study included 220 consecutive patients. Mean serum creatinine levels were 95, 57 and 61 mmol/L, for PHH, PHH + ST and ST groups, respectively (p < 0.001). Glomerular Filtration Rate (GFR) were 96, 94 and 78 ml/min/1.73 m2, respectively (p < 0.001). AKI and CKI are respectively for PHH, PHH + ST and ST groups were 21 % (n = 46), 1 % (n = 2) and 0 % vs 19 % (n = 42), 0 % and 0 % (p < 0.001), for pairwise analysis did not show any difference between PHH + ST and ST alone combination, regarding nephrological outcomes. All patients were followed 3 months postoperatively.
There is no need for preoperative hyperhydration when sodium-thiosulfate is used to prevent cisplatin-induced nephrotoxicity in patients undergoing cytoreductive surgery with HIPEC. These findings have implications for improving and simplifying the management of patients with peritoneal metastases undergoing HIPEC with cisplatin.</description><issn>0748-7983</issn><issn>1532-2157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kcGO0zAQhi0EYrsLL8AB-cglxXacOEZcVlVhV1oJJOBsufaEukrjYCcVufEOvATPxZPshC4cOVma-f_PM_MT8oKzNWe8fn1YwyHHtWBCYkHpqnpEVrwqRSF4pR6TFVOyKZRuygtymfOBMaZLpZ-Si7IRXNdar8ivbReOobdj6L_ScQ-0B_C0jYkOCeIACTsnoKEfkz1BH6dM9zOW97NfWrF_Qz9FH6YjmkPMU9faEajNyBn2KY7xe3BhnBca2hcDsujN7cftphgToNjTAUHYy_T3j5_0miYYU8wDuD8_2952cw75GXnS2i7D84f3inx5t_28uSnuPry_3VzfFU4yNhbaNxoaCUIBr3b1TklXCdAaF7dS-lbw2lW1ZWDVTrZ1pVQpma-ZAOlacKK8Iq_O3CHFbxPk0RxDdtB1tgfc3gjNpahqPC1KxVnqcN6coDVDCkebZsOZWRIyB7MkZJaEzDkhNL184E-7I_h_lr-RoODtWQC45SlAMtnheRz4kPAmxsfwP_49n3uoAQ</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Vachez, Elea</creator><creator>Kefleyesus, Amaniel</creator><creator>Bakrin, Naoual</creator><creator>Ranchon, Florence</creator><creator>Rioufol, Catherine</creator><creator>Vassal, Olivia</creator><creator>Al-Hadeedi, Omar</creator><creator>Kepenekian, Vahan</creator><creator>Glehen, Olivier</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9885-8600</orcidid><orcidid>https://orcid.org/0000-0002-9181-4231</orcidid><orcidid>https://orcid.org/0000-0002-7951-4041</orcidid></search><sort><creationdate>20240201</creationdate><title>Eliminating the need for preoperative intravenous hyperhydration: Sodium thiosulfate as nephrotoxicity prevention in HIPEC-treated patients – A retrospective analysis</title><author>Vachez, Elea ; Kefleyesus, Amaniel ; Bakrin, Naoual ; Ranchon, Florence ; Rioufol, Catherine ; Vassal, Olivia ; Al-Hadeedi, Omar ; Kepenekian, Vahan ; Glehen, Olivier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-9d89e84e27e15b6b74c52e99937a44df216c56a0ea7b4f6577340d602e4cfec23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vachez, Elea</creatorcontrib><creatorcontrib>Kefleyesus, Amaniel</creatorcontrib><creatorcontrib>Bakrin, Naoual</creatorcontrib><creatorcontrib>Ranchon, Florence</creatorcontrib><creatorcontrib>Rioufol, Catherine</creatorcontrib><creatorcontrib>Vassal, Olivia</creatorcontrib><creatorcontrib>Al-Hadeedi, Omar</creatorcontrib><creatorcontrib>Kepenekian, Vahan</creatorcontrib><creatorcontrib>Glehen, Olivier</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vachez, Elea</au><au>Kefleyesus, Amaniel</au><au>Bakrin, Naoual</au><au>Ranchon, Florence</au><au>Rioufol, Catherine</au><au>Vassal, Olivia</au><au>Al-Hadeedi, Omar</au><au>Kepenekian, Vahan</au><au>Glehen, Olivier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eliminating the need for preoperative intravenous hyperhydration: Sodium thiosulfate as nephrotoxicity prevention in HIPEC-treated patients – A retrospective analysis</atitle><jtitle>European journal of surgical oncology</jtitle><addtitle>Eur J Surg Oncol</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>50</volume><issue>2</issue><spage>107955</spage><epage>107955</epage><pages>107955-107955</pages><artnum>107955</artnum><issn>0748-7983</issn><eissn>1532-2157</eissn><abstract>Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for peritoneal metastases. However, HIPEC with cisplatin is associated with renal toxicity. Sodium thiosulfate (ST) has been shown to prevent cisplatin-induced toxicity.
A retrospective, single-center analysis of patients treated curatively for peritoneal surface malignancy, who underwent cytoreductive surgery with cisplatin-based HIPEC between 2015 and 2020. Patients were categorized into three groups based on the management of cisplatin-induced renal toxicity: preoperative hyperhydration alone (PHH), preoperative hyperhydration with ST (PHH + ST), and ST alone. Renal function and complications, in terms of Acute (AKI) and chronic kidney injury (CKI), were monitored and analyzed during 3 postoperative months.
This study included 220 consecutive patients. Mean serum creatinine levels were 95, 57 and 61 mmol/L, for PHH, PHH + ST and ST groups, respectively (p < 0.001). Glomerular Filtration Rate (GFR) were 96, 94 and 78 ml/min/1.73 m2, respectively (p < 0.001). AKI and CKI are respectively for PHH, PHH + ST and ST groups were 21 % (n = 46), 1 % (n = 2) and 0 % vs 19 % (n = 42), 0 % and 0 % (p < 0.001), for pairwise analysis did not show any difference between PHH + ST and ST alone combination, regarding nephrological outcomes. All patients were followed 3 months postoperatively.
There is no need for preoperative hyperhydration when sodium-thiosulfate is used to prevent cisplatin-induced nephrotoxicity in patients undergoing cytoreductive surgery with HIPEC. These findings have implications for improving and simplifying the management of patients with peritoneal metastases undergoing HIPEC with cisplatin.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38219699</pmid><doi>10.1016/j.ejso.2024.107955</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-9885-8600</orcidid><orcidid>https://orcid.org/0000-0002-9181-4231</orcidid><orcidid>https://orcid.org/0000-0002-7951-4041</orcidid><oa>free_for_read</oa></addata></record> |
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| title | Eliminating the need for preoperative intravenous hyperhydration: Sodium thiosulfate as nephrotoxicity prevention in HIPEC-treated patients – A retrospective analysis |
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