The impact of the Mediterranean diet on alleviating depressive symptoms in adults: a systematic review and meta-analysis of randomized controlled trials

High adherence to the Mediterranean diet (MD) has been associated with a reduced risk of depression in prospective cohort studies, but whether MD interventions are effective among adults with depression is uncertain. This study aimed to synthesize findings on the effects of MD interventions on the s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nutrition reviews 2025-01, Vol.83 (1), p.29
Hauptverfasser: Bizzozero-Peroni, Bruno, Martínez-Vizcaíno, Vicente, Fernández-Rodríguez, Rubén, Jiménez-López, Estela, Núñez de Arenas-Arroyo, Sergio, Saz-Lara, Alicia, Díaz-Goñi, Valentina, Mesas, Arthur Eumann
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 1
container_start_page 29
container_title Nutrition reviews
container_volume 83
creator Bizzozero-Peroni, Bruno
Martínez-Vizcaíno, Vicente
Fernández-Rodríguez, Rubén
Jiménez-López, Estela
Núñez de Arenas-Arroyo, Sergio
Saz-Lara, Alicia
Díaz-Goñi, Valentina
Mesas, Arthur Eumann
description High adherence to the Mediterranean diet (MD) has been associated with a reduced risk of depression in prospective cohort studies, but whether MD interventions are effective among adults with depression is uncertain. This study aimed to synthesize findings on the effects of MD interventions on the severity of depressive symptoms in adults with depression. PubMed, Cochrane CENTRAL, PsycINFO, Scopus, and Web of Science were systematically searched from database inception to March 2023. The Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines and the Cochrane recommendations were followed. We included randomized controlled trials (RCTs) comparing outcomes after MD interventions with outcomes for control conditions in adults with depressive disorders or depressive symptoms. Two authors extracted the data independently. The Sidik-Jonkman estimator, the I2 metric, and the prediction interval were used to estimate between-study heterogeneity. To determine the risk of bias and the certainty of evidence from RCTs, we used the Cochrane Collaboration's Risk of Bias 2 and Grades of Recommendation, Assessment, Development, and Evaluation tools, respectively. In total, 1507 participants (mean age range: 22.0 years-53.3 years) with depression were initially included in the 5 RCTs of this review. Compared with control conditions, MD interventions significantly reduced depressive symptoms among young and middle-aged adults with major depression or mild to moderate depressive symptoms (standardized mean difference: -0.53; 95% confidence interval: -0.90 to -0.16; I2 = 87.1%). The prediction interval ranged from -1.86 to 0.81. The overall risk of bias was within the range of "some concerns" to "high," while the certainty of evidence was low. MD interventions appear to have substantial potential for alleviating depressive symptoms in people experiencing major or mild depression. However, to establish robust recommendations, there remains a need for high-quality, large-scale, and long-term RCTs. PROSPERO registration no. CRD42022341895.
doi_str_mv 10.1093/nutrit/nuad176
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2914255973</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2914255973</sourcerecordid><originalsourceid>FETCH-LOGICAL-c225t-e47284b05df97021302a44610c49406ba1be36480dea5eb4606397a56d27f7973</originalsourceid><addsrcrecordid>eNo9kU9P3DAQxa0KBFvgyrHykUu2_hc77g0haCtRcaHnaBJPiqs4SW2HavtJ-LgY7dLT04x_M0_jR8glZ1vOrPw8rTn6XAQcN_oD2XBTy0o1jTkiG8aErbRW8pR8TOk3Y4wLK0_IqWwEt0KyDXl5fELqwwJ9pvNAc6l-oPMZY4QJYaLOY3mZKIwjPnvIfvpFHS4RU_LPSNMuLHkOifqCuHXM6QuF0k0ZQ4F7GssU_qUwORowQwUTjLvk05tbsXBz8P_Q0X6ecpyLh6PlIBjTOTkeiuDFQc_Iz7vbx5tv1f3D1-831_dVL0SdK1RGNKpjtRusYYJLJkApzVmvrGK6A96h1KphDqHGTmmmpTVQayfMYKyRZ-Rqv3eJ858VU26DTz2OYzl_XlMrLFeirgtZ0O0e7eOcUsShXaIPEHctZ-1bGu0-jfaQRhn4dNi9dgHdf_z9--UrEAyLVQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2914255973</pqid></control><display><type>article</type><title>The impact of the Mediterranean diet on alleviating depressive symptoms in adults: a systematic review and meta-analysis of randomized controlled trials</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Bizzozero-Peroni, Bruno ; Martínez-Vizcaíno, Vicente ; Fernández-Rodríguez, Rubén ; Jiménez-López, Estela ; Núñez de Arenas-Arroyo, Sergio ; Saz-Lara, Alicia ; Díaz-Goñi, Valentina ; Mesas, Arthur Eumann</creator><creatorcontrib>Bizzozero-Peroni, Bruno ; Martínez-Vizcaíno, Vicente ; Fernández-Rodríguez, Rubén ; Jiménez-López, Estela ; Núñez de Arenas-Arroyo, Sergio ; Saz-Lara, Alicia ; Díaz-Goñi, Valentina ; Mesas, Arthur Eumann</creatorcontrib><description>High adherence to the Mediterranean diet (MD) has been associated with a reduced risk of depression in prospective cohort studies, but whether MD interventions are effective among adults with depression is uncertain. This study aimed to synthesize findings on the effects of MD interventions on the severity of depressive symptoms in adults with depression. PubMed, Cochrane CENTRAL, PsycINFO, Scopus, and Web of Science were systematically searched from database inception to March 2023. The Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines and the Cochrane recommendations were followed. We included randomized controlled trials (RCTs) comparing outcomes after MD interventions with outcomes for control conditions in adults with depressive disorders or depressive symptoms. Two authors extracted the data independently. The Sidik-Jonkman estimator, the I2 metric, and the prediction interval were used to estimate between-study heterogeneity. To determine the risk of bias and the certainty of evidence from RCTs, we used the Cochrane Collaboration's Risk of Bias 2 and Grades of Recommendation, Assessment, Development, and Evaluation tools, respectively. In total, 1507 participants (mean age range: 22.0 years-53.3 years) with depression were initially included in the 5 RCTs of this review. Compared with control conditions, MD interventions significantly reduced depressive symptoms among young and middle-aged adults with major depression or mild to moderate depressive symptoms (standardized mean difference: -0.53; 95% confidence interval: -0.90 to -0.16; I2 = 87.1%). The prediction interval ranged from -1.86 to 0.81. The overall risk of bias was within the range of "some concerns" to "high," while the certainty of evidence was low. MD interventions appear to have substantial potential for alleviating depressive symptoms in people experiencing major or mild depression. However, to establish robust recommendations, there remains a need for high-quality, large-scale, and long-term RCTs. PROSPERO registration no. CRD42022341895.</description><identifier>ISSN: 0029-6643</identifier><identifier>ISSN: 1753-4887</identifier><identifier>EISSN: 1753-4887</identifier><identifier>DOI: 10.1093/nutrit/nuad176</identifier><identifier>PMID: 38219230</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Depression - prevention &amp; control ; Diet, Mediterranean ; Humans ; Middle Aged ; Randomized Controlled Trials as Topic</subject><ispartof>Nutrition reviews, 2025-01, Vol.83 (1), p.29</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c225t-e47284b05df97021302a44610c49406ba1be36480dea5eb4606397a56d27f7973</citedby><cites>FETCH-LOGICAL-c225t-e47284b05df97021302a44610c49406ba1be36480dea5eb4606397a56d27f7973</cites><orcidid>0000-0001-7774-8437 ; 0000-0003-0669-8625 ; 0000-0001-7504-1534 ; 0000-0002-1724-1893 ; 0000-0001-6121-7893 ; 0000-0003-0614-5561 ; 0000-0001-8553-7701 ; 0000-0002-0088-8607</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38219230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bizzozero-Peroni, Bruno</creatorcontrib><creatorcontrib>Martínez-Vizcaíno, Vicente</creatorcontrib><creatorcontrib>Fernández-Rodríguez, Rubén</creatorcontrib><creatorcontrib>Jiménez-López, Estela</creatorcontrib><creatorcontrib>Núñez de Arenas-Arroyo, Sergio</creatorcontrib><creatorcontrib>Saz-Lara, Alicia</creatorcontrib><creatorcontrib>Díaz-Goñi, Valentina</creatorcontrib><creatorcontrib>Mesas, Arthur Eumann</creatorcontrib><title>The impact of the Mediterranean diet on alleviating depressive symptoms in adults: a systematic review and meta-analysis of randomized controlled trials</title><title>Nutrition reviews</title><addtitle>Nutr Rev</addtitle><description>High adherence to the Mediterranean diet (MD) has been associated with a reduced risk of depression in prospective cohort studies, but whether MD interventions are effective among adults with depression is uncertain. This study aimed to synthesize findings on the effects of MD interventions on the severity of depressive symptoms in adults with depression. PubMed, Cochrane CENTRAL, PsycINFO, Scopus, and Web of Science were systematically searched from database inception to March 2023. The Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines and the Cochrane recommendations were followed. We included randomized controlled trials (RCTs) comparing outcomes after MD interventions with outcomes for control conditions in adults with depressive disorders or depressive symptoms. Two authors extracted the data independently. The Sidik-Jonkman estimator, the I2 metric, and the prediction interval were used to estimate between-study heterogeneity. To determine the risk of bias and the certainty of evidence from RCTs, we used the Cochrane Collaboration's Risk of Bias 2 and Grades of Recommendation, Assessment, Development, and Evaluation tools, respectively. In total, 1507 participants (mean age range: 22.0 years-53.3 years) with depression were initially included in the 5 RCTs of this review. Compared with control conditions, MD interventions significantly reduced depressive symptoms among young and middle-aged adults with major depression or mild to moderate depressive symptoms (standardized mean difference: -0.53; 95% confidence interval: -0.90 to -0.16; I2 = 87.1%). The prediction interval ranged from -1.86 to 0.81. The overall risk of bias was within the range of "some concerns" to "high," while the certainty of evidence was low. MD interventions appear to have substantial potential for alleviating depressive symptoms in people experiencing major or mild depression. However, to establish robust recommendations, there remains a need for high-quality, large-scale, and long-term RCTs. PROSPERO registration no. CRD42022341895.</description><subject>Adult</subject><subject>Depression - prevention &amp; control</subject><subject>Diet, Mediterranean</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Randomized Controlled Trials as Topic</subject><issn>0029-6643</issn><issn>1753-4887</issn><issn>1753-4887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU9P3DAQxa0KBFvgyrHykUu2_hc77g0haCtRcaHnaBJPiqs4SW2HavtJ-LgY7dLT04x_M0_jR8glZ1vOrPw8rTn6XAQcN_oD2XBTy0o1jTkiG8aErbRW8pR8TOk3Y4wLK0_IqWwEt0KyDXl5fELqwwJ9pvNAc6l-oPMZY4QJYaLOY3mZKIwjPnvIfvpFHS4RU_LPSNMuLHkOifqCuHXM6QuF0k0ZQ4F7GssU_qUwORowQwUTjLvk05tbsXBz8P_Q0X6ecpyLh6PlIBjTOTkeiuDFQc_Iz7vbx5tv1f3D1-831_dVL0SdK1RGNKpjtRusYYJLJkApzVmvrGK6A96h1KphDqHGTmmmpTVQayfMYKyRZ-Rqv3eJ858VU26DTz2OYzl_XlMrLFeirgtZ0O0e7eOcUsShXaIPEHctZ-1bGu0-jfaQRhn4dNi9dgHdf_z9--UrEAyLVQ</recordid><startdate>20250101</startdate><enddate>20250101</enddate><creator>Bizzozero-Peroni, Bruno</creator><creator>Martínez-Vizcaíno, Vicente</creator><creator>Fernández-Rodríguez, Rubén</creator><creator>Jiménez-López, Estela</creator><creator>Núñez de Arenas-Arroyo, Sergio</creator><creator>Saz-Lara, Alicia</creator><creator>Díaz-Goñi, Valentina</creator><creator>Mesas, Arthur Eumann</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7774-8437</orcidid><orcidid>https://orcid.org/0000-0003-0669-8625</orcidid><orcidid>https://orcid.org/0000-0001-7504-1534</orcidid><orcidid>https://orcid.org/0000-0002-1724-1893</orcidid><orcidid>https://orcid.org/0000-0001-6121-7893</orcidid><orcidid>https://orcid.org/0000-0003-0614-5561</orcidid><orcidid>https://orcid.org/0000-0001-8553-7701</orcidid><orcidid>https://orcid.org/0000-0002-0088-8607</orcidid></search><sort><creationdate>20250101</creationdate><title>The impact of the Mediterranean diet on alleviating depressive symptoms in adults: a systematic review and meta-analysis of randomized controlled trials</title><author>Bizzozero-Peroni, Bruno ; Martínez-Vizcaíno, Vicente ; Fernández-Rodríguez, Rubén ; Jiménez-López, Estela ; Núñez de Arenas-Arroyo, Sergio ; Saz-Lara, Alicia ; Díaz-Goñi, Valentina ; Mesas, Arthur Eumann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c225t-e47284b05df97021302a44610c49406ba1be36480dea5eb4606397a56d27f7973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adult</topic><topic>Depression - prevention &amp; control</topic><topic>Diet, Mediterranean</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Randomized Controlled Trials as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bizzozero-Peroni, Bruno</creatorcontrib><creatorcontrib>Martínez-Vizcaíno, Vicente</creatorcontrib><creatorcontrib>Fernández-Rodríguez, Rubén</creatorcontrib><creatorcontrib>Jiménez-López, Estela</creatorcontrib><creatorcontrib>Núñez de Arenas-Arroyo, Sergio</creatorcontrib><creatorcontrib>Saz-Lara, Alicia</creatorcontrib><creatorcontrib>Díaz-Goñi, Valentina</creatorcontrib><creatorcontrib>Mesas, Arthur Eumann</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bizzozero-Peroni, Bruno</au><au>Martínez-Vizcaíno, Vicente</au><au>Fernández-Rodríguez, Rubén</au><au>Jiménez-López, Estela</au><au>Núñez de Arenas-Arroyo, Sergio</au><au>Saz-Lara, Alicia</au><au>Díaz-Goñi, Valentina</au><au>Mesas, Arthur Eumann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of the Mediterranean diet on alleviating depressive symptoms in adults: a systematic review and meta-analysis of randomized controlled trials</atitle><jtitle>Nutrition reviews</jtitle><addtitle>Nutr Rev</addtitle><date>2025-01-01</date><risdate>2025</risdate><volume>83</volume><issue>1</issue><spage>29</spage><pages>29-</pages><issn>0029-6643</issn><issn>1753-4887</issn><eissn>1753-4887</eissn><abstract>High adherence to the Mediterranean diet (MD) has been associated with a reduced risk of depression in prospective cohort studies, but whether MD interventions are effective among adults with depression is uncertain. This study aimed to synthesize findings on the effects of MD interventions on the severity of depressive symptoms in adults with depression. PubMed, Cochrane CENTRAL, PsycINFO, Scopus, and Web of Science were systematically searched from database inception to March 2023. The Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines and the Cochrane recommendations were followed. We included randomized controlled trials (RCTs) comparing outcomes after MD interventions with outcomes for control conditions in adults with depressive disorders or depressive symptoms. Two authors extracted the data independently. The Sidik-Jonkman estimator, the I2 metric, and the prediction interval were used to estimate between-study heterogeneity. To determine the risk of bias and the certainty of evidence from RCTs, we used the Cochrane Collaboration's Risk of Bias 2 and Grades of Recommendation, Assessment, Development, and Evaluation tools, respectively. In total, 1507 participants (mean age range: 22.0 years-53.3 years) with depression were initially included in the 5 RCTs of this review. Compared with control conditions, MD interventions significantly reduced depressive symptoms among young and middle-aged adults with major depression or mild to moderate depressive symptoms (standardized mean difference: -0.53; 95% confidence interval: -0.90 to -0.16; I2 = 87.1%). The prediction interval ranged from -1.86 to 0.81. The overall risk of bias was within the range of "some concerns" to "high," while the certainty of evidence was low. MD interventions appear to have substantial potential for alleviating depressive symptoms in people experiencing major or mild depression. However, to establish robust recommendations, there remains a need for high-quality, large-scale, and long-term RCTs. PROSPERO registration no. CRD42022341895.</abstract><cop>United States</cop><pmid>38219230</pmid><doi>10.1093/nutrit/nuad176</doi><orcidid>https://orcid.org/0000-0001-7774-8437</orcidid><orcidid>https://orcid.org/0000-0003-0669-8625</orcidid><orcidid>https://orcid.org/0000-0001-7504-1534</orcidid><orcidid>https://orcid.org/0000-0002-1724-1893</orcidid><orcidid>https://orcid.org/0000-0001-6121-7893</orcidid><orcidid>https://orcid.org/0000-0003-0614-5561</orcidid><orcidid>https://orcid.org/0000-0001-8553-7701</orcidid><orcidid>https://orcid.org/0000-0002-0088-8607</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0029-6643
ispartof Nutrition reviews, 2025-01, Vol.83 (1), p.29
issn 0029-6643
1753-4887
1753-4887
language eng
recordid cdi_proquest_miscellaneous_2914255973
source MEDLINE; Oxford University Press Journals All Titles (1996-Current)
subjects Adult
Depression - prevention & control
Diet, Mediterranean
Humans
Middle Aged
Randomized Controlled Trials as Topic
title The impact of the Mediterranean diet on alleviating depressive symptoms in adults: a systematic review and meta-analysis of randomized controlled trials
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T11%3A53%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20impact%20of%20the%20Mediterranean%20diet%20on%20alleviating%20depressive%20symptoms%20in%20adults:%20a%20systematic%20review%20and%20meta-analysis%20of%20randomized%20controlled%20trials&rft.jtitle=Nutrition%20reviews&rft.au=Bizzozero-Peroni,%20Bruno&rft.date=2025-01-01&rft.volume=83&rft.issue=1&rft.spage=29&rft.pages=29-&rft.issn=0029-6643&rft.eissn=1753-4887&rft_id=info:doi/10.1093/nutrit/nuad176&rft_dat=%3Cproquest_cross%3E2914255973%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2914255973&rft_id=info:pmid/38219230&rfr_iscdi=true