Utility of nifedipine use for Doppler ultrasound early after liver transplantation to predict short-term complications and long-term outcomes
Purpose To evaluate the response to nifedipine administration measured by changes in hepatic arterial (HA) flow on post-operative Doppler ultrasound (US) to predict short-term complications and long-term outcomes in liver transplant (LT) patients. Methods Patients who underwent LT with post-operativ...
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| Veröffentlicht in: | Abdominal imaging 2024-04, Vol.49 (4), p.1103-1112 |
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| creator | Kadaba, Priyanka Beitia, Laura Rosen, Ally Weinberg, Alan Lewis, Sara Simpson, William L. |
| description | Purpose
To evaluate the response to nifedipine administration measured by changes in hepatic arterial (HA) flow on post-operative Doppler ultrasound (US) to predict short-term complications and long-term outcomes in liver transplant (LT) patients.
Methods
Patients who underwent LT with post-operative Doppler US within 3 days between 1 January 2005 and 31 December 2015 were included in this retrospective single center study. The patients who received and did not receive nifedipine during the Doppler US comprised the study and control groups, respectively. A positive response to nifedipine was defined as the detection of HA flow when none was present initially or a reduction in HA resistive index (RI) ≥ 0.1 after nifedipine administration. The rates of re-transplantation, re-operation, percutaneous intervention (PCI), and overall survival (OS) were recorded. Cox proportional hazards regression was used to evaluate the association of clinic-demographic variables and Doppler findings with the outcome measures.
Results
444 LT patients (305 M/139F, mean age 51.7 ± 17.4 years, mean interval between LT-Doppler US 1.12 ± 0.9 days) are presented. 220 patients comprised the nifedipine study group [
n
= 157/220 (71.4%) responder,
n
= 63/220 (28.6%) nonresponder] and 224 patients comprised the control group. There was no difference in re-transplantation or PCI rates between the groups (all
p
-values ≥ 0.2 and ≥ 0.08, respectively). The responder group had a lower rate of re-operation vs. the control group (15.9% vs. 24.1%,
p
= 0.03) and nonresponder group (15.9% vs. 31.8%,
p
= 0.004). 1-year and 2-year OS were similar between the groups (all
p
-values > 0.37).
Conclusion
Short-term complication rates and long-term outcomes for patients with liver transplant who responded to nifedipine administration on Doppler US are similar to those who did not require nifedipine administration. A lack of response to nifedipine was associated with a higher re-operation rate. |
| doi_str_mv | 10.1007/s00261-023-04152-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2914255919</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2969405424</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-d132e2aac7ff54036f1aa5b34cc170bd29cfa0e24576d4e0afe89ed0c76697f73</originalsourceid><addsrcrecordid>eNp9kctq3TAQhkVpSUKaF8iiCLrpxuno6uNlSa8QyCZZCx15lCrIlivJhfMQeeeqcXqhi240Qv83_2j4CTlncMEA-rcFgGvWARcdSKZ4B8_ICRdadwBq9_yv-zE5K-UeAJhWjHF1RI7FjrOBK3FCHm5riKEeaPJ0Dh7HsIQZ6VqQ-pTp-7QsETNdY822pHUeKdocD9T62p5j-N7OJs1liXautoY005rokpuTq7R8Tbl2DZ2oS9MSg3tECrXNKab5btPSWpuM5SV54W0sePZUT8ntxw83l5-7q-tPXy7fXXVOcF27kQmO3FrXe68kCO2ZtWovpHOsh_3IB-ctIJeq16NEsB53A47geq2H3vfilLzZfJecvq1YqplCcRjbDpjWYvjAJFdqYENDX_-D3qc1z-13jdKDBCW5bBTfKJdTKRm9WXKYbD4YBuZnXmbLy7S8zGNeBlrTqyfrdT_h-LvlVzoNEBtQmjTfYf4z-z-2PwAxwKOE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2969405424</pqid></control><display><type>article</type><title>Utility of nifedipine use for Doppler ultrasound early after liver transplantation to predict short-term complications and long-term outcomes</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Kadaba, Priyanka ; Beitia, Laura ; Rosen, Ally ; Weinberg, Alan ; Lewis, Sara ; Simpson, William L.</creator><creatorcontrib>Kadaba, Priyanka ; Beitia, Laura ; Rosen, Ally ; Weinberg, Alan ; Lewis, Sara ; Simpson, William L.</creatorcontrib><description>Purpose
To evaluate the response to nifedipine administration measured by changes in hepatic arterial (HA) flow on post-operative Doppler ultrasound (US) to predict short-term complications and long-term outcomes in liver transplant (LT) patients.
Methods
Patients who underwent LT with post-operative Doppler US within 3 days between 1 January 2005 and 31 December 2015 were included in this retrospective single center study. The patients who received and did not receive nifedipine during the Doppler US comprised the study and control groups, respectively. A positive response to nifedipine was defined as the detection of HA flow when none was present initially or a reduction in HA resistive index (RI) ≥ 0.1 after nifedipine administration. The rates of re-transplantation, re-operation, percutaneous intervention (PCI), and overall survival (OS) were recorded. Cox proportional hazards regression was used to evaluate the association of clinic-demographic variables and Doppler findings with the outcome measures.
Results
444 LT patients (305 M/139F, mean age 51.7 ± 17.4 years, mean interval between LT-Doppler US 1.12 ± 0.9 days) are presented. 220 patients comprised the nifedipine study group [
n
= 157/220 (71.4%) responder,
n
= 63/220 (28.6%) nonresponder] and 224 patients comprised the control group. There was no difference in re-transplantation or PCI rates between the groups (all
p
-values ≥ 0.2 and ≥ 0.08, respectively). The responder group had a lower rate of re-operation vs. the control group (15.9% vs. 24.1%,
p
= 0.03) and nonresponder group (15.9% vs. 31.8%,
p
= 0.004). 1-year and 2-year OS were similar between the groups (all
p
-values > 0.37).
Conclusion
Short-term complication rates and long-term outcomes for patients with liver transplant who responded to nifedipine administration on Doppler US are similar to those who did not require nifedipine administration. A lack of response to nifedipine was associated with a higher re-operation rate.</description><identifier>ISSN: 2366-0058</identifier><identifier>ISSN: 2366-004X</identifier><identifier>EISSN: 2366-0058</identifier><identifier>DOI: 10.1007/s00261-023-04152-0</identifier><identifier>PMID: 38219253</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Demographic variables ; Doppler effect ; Gastroenterology ; Hepatic Artery - diagnostic imaging ; Hepatobiliary ; Hepatology ; Humans ; Imaging ; Infant ; Liver ; Liver transplantation ; Liver Transplantation - adverse effects ; Liver transplants ; Medicine ; Medicine & Public Health ; Nifedipine ; Nifedipine - therapeutic use ; Percutaneous Coronary Intervention ; Percutaneous treatment ; Radiology ; Retrospective Studies ; Transplantation ; Ultrasonic imaging ; Ultrasonography, Doppler ; Ultrasound</subject><ispartof>Abdominal imaging, 2024-04, Vol.49 (4), p.1103-1112</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-d132e2aac7ff54036f1aa5b34cc170bd29cfa0e24576d4e0afe89ed0c76697f73</cites><orcidid>0000-0002-2756-2519</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00261-023-04152-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00261-023-04152-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38219253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kadaba, Priyanka</creatorcontrib><creatorcontrib>Beitia, Laura</creatorcontrib><creatorcontrib>Rosen, Ally</creatorcontrib><creatorcontrib>Weinberg, Alan</creatorcontrib><creatorcontrib>Lewis, Sara</creatorcontrib><creatorcontrib>Simpson, William L.</creatorcontrib><title>Utility of nifedipine use for Doppler ultrasound early after liver transplantation to predict short-term complications and long-term outcomes</title><title>Abdominal imaging</title><addtitle>Abdom Radiol</addtitle><addtitle>Abdom Radiol (NY)</addtitle><description>Purpose
To evaluate the response to nifedipine administration measured by changes in hepatic arterial (HA) flow on post-operative Doppler ultrasound (US) to predict short-term complications and long-term outcomes in liver transplant (LT) patients.
Methods
Patients who underwent LT with post-operative Doppler US within 3 days between 1 January 2005 and 31 December 2015 were included in this retrospective single center study. The patients who received and did not receive nifedipine during the Doppler US comprised the study and control groups, respectively. A positive response to nifedipine was defined as the detection of HA flow when none was present initially or a reduction in HA resistive index (RI) ≥ 0.1 after nifedipine administration. The rates of re-transplantation, re-operation, percutaneous intervention (PCI), and overall survival (OS) were recorded. Cox proportional hazards regression was used to evaluate the association of clinic-demographic variables and Doppler findings with the outcome measures.
Results
444 LT patients (305 M/139F, mean age 51.7 ± 17.4 years, mean interval between LT-Doppler US 1.12 ± 0.9 days) are presented. 220 patients comprised the nifedipine study group [
n
= 157/220 (71.4%) responder,
n
= 63/220 (28.6%) nonresponder] and 224 patients comprised the control group. There was no difference in re-transplantation or PCI rates between the groups (all
p
-values ≥ 0.2 and ≥ 0.08, respectively). The responder group had a lower rate of re-operation vs. the control group (15.9% vs. 24.1%,
p
= 0.03) and nonresponder group (15.9% vs. 31.8%,
p
= 0.004). 1-year and 2-year OS were similar between the groups (all
p
-values > 0.37).
Conclusion
Short-term complication rates and long-term outcomes for patients with liver transplant who responded to nifedipine administration on Doppler US are similar to those who did not require nifedipine administration. A lack of response to nifedipine was associated with a higher re-operation rate.</description><subject>Demographic variables</subject><subject>Doppler effect</subject><subject>Gastroenterology</subject><subject>Hepatic Artery - diagnostic imaging</subject><subject>Hepatobiliary</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Infant</subject><subject>Liver</subject><subject>Liver transplantation</subject><subject>Liver Transplantation - adverse effects</subject><subject>Liver transplants</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nifedipine</subject><subject>Nifedipine - therapeutic use</subject><subject>Percutaneous Coronary Intervention</subject><subject>Percutaneous treatment</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Transplantation</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography, Doppler</subject><subject>Ultrasound</subject><issn>2366-0058</issn><issn>2366-004X</issn><issn>2366-0058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctq3TAQhkVpSUKaF8iiCLrpxuno6uNlSa8QyCZZCx15lCrIlivJhfMQeeeqcXqhi240Qv83_2j4CTlncMEA-rcFgGvWARcdSKZ4B8_ICRdadwBq9_yv-zE5K-UeAJhWjHF1RI7FjrOBK3FCHm5riKEeaPJ0Dh7HsIQZ6VqQ-pTp-7QsETNdY822pHUeKdocD9T62p5j-N7OJs1liXautoY005rokpuTq7R8Tbl2DZ2oS9MSg3tECrXNKab5btPSWpuM5SV54W0sePZUT8ntxw83l5-7q-tPXy7fXXVOcF27kQmO3FrXe68kCO2ZtWovpHOsh_3IB-ctIJeq16NEsB53A47geq2H3vfilLzZfJecvq1YqplCcRjbDpjWYvjAJFdqYENDX_-D3qc1z-13jdKDBCW5bBTfKJdTKRm9WXKYbD4YBuZnXmbLy7S8zGNeBlrTqyfrdT_h-LvlVzoNEBtQmjTfYf4z-z-2PwAxwKOE</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Kadaba, Priyanka</creator><creator>Beitia, Laura</creator><creator>Rosen, Ally</creator><creator>Weinberg, Alan</creator><creator>Lewis, Sara</creator><creator>Simpson, William L.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>JQ2</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2756-2519</orcidid></search><sort><creationdate>20240401</creationdate><title>Utility of nifedipine use for Doppler ultrasound early after liver transplantation to predict short-term complications and long-term outcomes</title><author>Kadaba, Priyanka ; Beitia, Laura ; Rosen, Ally ; Weinberg, Alan ; Lewis, Sara ; Simpson, William L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-d132e2aac7ff54036f1aa5b34cc170bd29cfa0e24576d4e0afe89ed0c76697f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Demographic variables</topic><topic>Doppler effect</topic><topic>Gastroenterology</topic><topic>Hepatic Artery - diagnostic imaging</topic><topic>Hepatobiliary</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Infant</topic><topic>Liver</topic><topic>Liver transplantation</topic><topic>Liver Transplantation - adverse effects</topic><topic>Liver transplants</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nifedipine</topic><topic>Nifedipine - therapeutic use</topic><topic>Percutaneous Coronary Intervention</topic><topic>Percutaneous treatment</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Transplantation</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography, Doppler</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kadaba, Priyanka</creatorcontrib><creatorcontrib>Beitia, Laura</creatorcontrib><creatorcontrib>Rosen, Ally</creatorcontrib><creatorcontrib>Weinberg, Alan</creatorcontrib><creatorcontrib>Lewis, Sara</creatorcontrib><creatorcontrib>Simpson, William L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Abdominal imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kadaba, Priyanka</au><au>Beitia, Laura</au><au>Rosen, Ally</au><au>Weinberg, Alan</au><au>Lewis, Sara</au><au>Simpson, William L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utility of nifedipine use for Doppler ultrasound early after liver transplantation to predict short-term complications and long-term outcomes</atitle><jtitle>Abdominal imaging</jtitle><stitle>Abdom Radiol</stitle><addtitle>Abdom Radiol (NY)</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>49</volume><issue>4</issue><spage>1103</spage><epage>1112</epage><pages>1103-1112</pages><issn>2366-0058</issn><issn>2366-004X</issn><eissn>2366-0058</eissn><abstract>Purpose
To evaluate the response to nifedipine administration measured by changes in hepatic arterial (HA) flow on post-operative Doppler ultrasound (US) to predict short-term complications and long-term outcomes in liver transplant (LT) patients.
Methods
Patients who underwent LT with post-operative Doppler US within 3 days between 1 January 2005 and 31 December 2015 were included in this retrospective single center study. The patients who received and did not receive nifedipine during the Doppler US comprised the study and control groups, respectively. A positive response to nifedipine was defined as the detection of HA flow when none was present initially or a reduction in HA resistive index (RI) ≥ 0.1 after nifedipine administration. The rates of re-transplantation, re-operation, percutaneous intervention (PCI), and overall survival (OS) were recorded. Cox proportional hazards regression was used to evaluate the association of clinic-demographic variables and Doppler findings with the outcome measures.
Results
444 LT patients (305 M/139F, mean age 51.7 ± 17.4 years, mean interval between LT-Doppler US 1.12 ± 0.9 days) are presented. 220 patients comprised the nifedipine study group [
n
= 157/220 (71.4%) responder,
n
= 63/220 (28.6%) nonresponder] and 224 patients comprised the control group. There was no difference in re-transplantation or PCI rates between the groups (all
p
-values ≥ 0.2 and ≥ 0.08, respectively). The responder group had a lower rate of re-operation vs. the control group (15.9% vs. 24.1%,
p
= 0.03) and nonresponder group (15.9% vs. 31.8%,
p
= 0.004). 1-year and 2-year OS were similar between the groups (all
p
-values > 0.37).
Conclusion
Short-term complication rates and long-term outcomes for patients with liver transplant who responded to nifedipine administration on Doppler US are similar to those who did not require nifedipine administration. A lack of response to nifedipine was associated with a higher re-operation rate.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38219253</pmid><doi>10.1007/s00261-023-04152-0</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-2756-2519</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2366-0058 |
| ispartof | Abdominal imaging, 2024-04, Vol.49 (4), p.1103-1112 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Demographic variables Doppler effect Gastroenterology Hepatic Artery - diagnostic imaging Hepatobiliary Hepatology Humans Imaging Infant Liver Liver transplantation Liver Transplantation - adverse effects Liver transplants Medicine Medicine & Public Health Nifedipine Nifedipine - therapeutic use Percutaneous Coronary Intervention Percutaneous treatment Radiology Retrospective Studies Transplantation Ultrasonic imaging Ultrasonography, Doppler Ultrasound |
| title | Utility of nifedipine use for Doppler ultrasound early after liver transplantation to predict short-term complications and long-term outcomes |
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