Investigating the role of thymol as a promising inhibitor of pyruvate dehydrogenase kinase 3 for targeted cancer therapy

Protein kinases have emerged as major contributors to various diseases. They are currently exploited as a potential target in drug discovery because they play crucial roles in cell signaling, growth, and regulation. Their dysregulation is associated with inflammatory disorders, cancer, and neurodege...

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Veröffentlicht in:	International journal of biological macromolecules 2024-02, Vol.259 (Pt 2), p.129314-129314, Article 129314
Hauptverfasser:	Jairajpuri, Deeba Shamim, Khan, Shama, Anwar, Saleha, Hussain, Afzal, Alajmi, Mohamed F., Hassan, Imtaiyaz
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer therapeutics Drug discovery Enzyme inhibition assay Humans Inflammatory disorders Molecular Docking Simulation Molecular dynamics simulation Natural compounds Neoplasms - drug therapy Protein kinases Protein Kinases - metabolism Pyruvate Dehydrogenase Acetyl-Transferring Kinase - chemistry Thymol - pharmacology
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