Icariin Regulates EMT and Stem Cell-Like Character in Breast Cancer through Modulating lncRNA NEAT1/TGFβ/SMAD2 Signaling Pathway

Metastases and drug resistance are the major risk factors associated with breast cancer (BC), which is the most common type of tumor affecting females. Icariin (ICA) is a traditional Chinese medicine compound that possesses significant anticancer properties. Long non-coding RNAs (lncRNAs) are involv...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2024/02/10, Vol.47(2), pp.399-410
Hauptverfasser:	Song, Bo, Wei, Fuxia, Peng, Jiehao, Wei, Xiuhong, Liu, Mingran, Nie, Zhongbiao, Ma, Yanmiao, Peng, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism cancer stem cell-like character Cell Line, Tumor Cell Movement Cell Proliferation Drug resistance epithelial mesenchymal transition (EMT) Epithelial-Mesenchymal Transition Female Flavonoids Humans icariin (ICA) Immunofluorescence long non-coding RNA (lncRNA) NEAT1 Metastases Non-coding RNA Risk factors RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction Smad2 protein Smad2 Protein - metabolism Stem cells Stem Cells - metabolism Traditional Chinese medicine Transforming Growth Factor beta - metabolism transforming growth factor β (TGFβ) SMAD2 Transforming growth factor-b Western blotting Wound healing
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