Targeted deletion of NR2F2 and VCAM1 in theca cells impacts ovarian follicular development: insights into polycystic ovary syndrome?

Defining features of polycystic ovary syndrome (PCOS) include elevated expression of steroidogenic genes, theca cell androgen biosynthesis, and peripheral levels of androgens. In previous studies, we identified vascular cell adhesion molecule 1 (VCAM1) as a selective androgen target gene in specific...

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Veröffentlicht in:	Biology of reproduction 2024-04, Vol.110 (4), p.782-797
Hauptverfasser:	Candelaria, Nicholes R., Richards, JoAnne S.
Format:	Artikel
Sprache:	eng
Schlagworte:	androgens Androgens - metabolism Animals biosynthesis cell differentiation COUP Transcription Factor II - genetics COUP Transcription Factor II - metabolism CYP11A1 CYP17A1 Editor's Choice Female follicular development gene expression genes gonadotropins granulosa cells Granulosa Cells - metabolism luteinization Mice NOTCH1 NR2F2 NR5A1 PCOS polycystic ovary syndrome Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - metabolism RESEARCH ARTICLE steroidogenesis theca cells Theca Cells - metabolism Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - metabolism vascular cell adhesion molecules VCAM1
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