Deterministic reprogramming of neutrophils within tumors
Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances characterizing the diversity of neutrophil states in cancer, common trajectories and mechanisms governing the ontogeny and relationship between...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2024-01, Vol.383 (6679), p.eadf6493 |
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| creator | Ng, Melissa S F Kwok, Immanuel Tan, Leonard Shi, Changming Cerezo-Wallis, Daniela Tan, Yingrou Leong, Keith Calvo, Gabriel F Yang, Katharine Zhang, Yuning Jin, Jingsi Liong, Ka Hang Wu, Dandan He, Rui Liu, Dehua Teh, Ye Chean Bleriot, Camille Caronni, Nicoletta Liu, Zhaoyuan Duan, Kaibo Narang, Vipin Ballesteros, Iván Moalli, Federica Li, Mengwei Chen, Jinmiao Liu, Yao Liu, Lianxin Qi, Jingjing Liu, Yingbin Jiang, Lingxi Shen, Baiyong Cheng, Hui Cheng, Tao Angeli, Veronique Sharma, Ankur Loh, Yuin-Han Tey, Hong Liang Chong, Shu Zhen Iannacone, Matteo Ostuni, Renato Hidalgo, Andrés Ginhoux, Florent Ng, Lai Guan |
| description | Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances characterizing the diversity of neutrophil states in cancer, common trajectories and mechanisms governing the ontogeny and relationship between these neutrophil states remain undefined. Here, we demonstrate that immature and mature neutrophils that enter tumors undergo irreversible epigenetic, transcriptional, and proteomic modifications to converge into a distinct, terminally differentiated dcTRAIL-R1
state. Reprogrammed dcTRAIL-R1
neutrophils predominantly localize to a glycolytic and hypoxic niche at the tumor core and exert pro-angiogenic function that favors tumor growth. We found similar trajectories in neutrophils across multiple tumor types and in humans, suggesting that targeting this program may provide a means of enhancing certain cancer immunotherapies. |
| doi_str_mv | 10.1126/science.adf6493 |
| format | Article |
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state. Reprogrammed dcTRAIL-R1
neutrophils predominantly localize to a glycolytic and hypoxic niche at the tumor core and exert pro-angiogenic function that favors tumor growth. We found similar trajectories in neutrophils across multiple tumor types and in humans, suggesting that targeting this program may provide a means of enhancing certain cancer immunotherapies.</description><identifier>ISSN: 0036-8075</identifier><identifier>ISSN: 1095-9203</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.adf6493</identifier><identifier>PMID: 38207030</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Ablation ; Angiogenesis ; Animal models ; Biomarkers ; Blood ; Blood vessels ; Bone marrow ; Cancer ; Cellular Reprogramming - genetics ; Cellular Reprogramming - immunology ; Chromatin ; Convergence ; Effector cells ; Emergency response ; Epigenesis, Genetic ; Flow cytometry ; Flow mapping ; Gene expression ; Gene sequencing ; Genotype & phenotype ; Glycolysis ; Growth factors ; Humans ; Hypoxia ; Immunotherapy ; Individualized Instruction ; Leukocytes (neutrophilic) ; Life span ; Localization ; Maturation ; Neoplasms - blood supply ; Neoplasms - immunology ; Neovascularization, Pathologic - genetics ; Neovascularization, Pathologic - immunology ; Neutrophils ; Neutrophils - immunology ; Nutrients ; Ontogeny ; Oxidative stress ; Pancreatic cancer ; Peptide mapping ; Phenotypes ; Populations ; Proteomics ; Receptors, TNF-Related Apoptosis-Inducing Ligand - immunology ; Ribonucleic acid ; RNA ; Solid tumors ; Surface markers ; Survival ; Therapeutic targets ; Transcription, Genetic ; Tumor cells ; Tumor microenvironment ; Tumors ; Vascular endothelial growth factor</subject><ispartof>Science (American Association for the Advancement of Science), 2024-01, Vol.383 (6679), p.eadf6493</ispartof><rights>Copyright © 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c325t-8dd7984d96c47c824e6807d76d689c4b3413ba72962154a657d7a728a6fc11653</citedby><cites>FETCH-LOGICAL-c325t-8dd7984d96c47c824e6807d76d689c4b3413ba72962154a657d7a728a6fc11653</cites><orcidid>0000-0002-6862-136X ; 0000-0003-1905-3586 ; 0000-0002-2857-7755 ; 0000-0002-4298-2888 ; 0000-0003-0155-2109 ; 0000-0002-6923-1021 ; 0000-0002-0568-3387 ; 0009-0003-3665-3978 ; 0000-0002-3994-248X ; 0000-0002-3117-0833 ; 0000-0002-5925-2769 ; 0000-0003-0365-3229 ; 0000-0002-2759-3497 ; 0000-0001-5513-555X ; 0000-0001-8894-6711 ; 0000-0002-3263-7108 ; 0000-0003-0460-3426 ; 0000-0002-6246-2353 ; 0000-0003-3826-2746 ; 0000-0002-7575-032X ; 0000-0002-8209-1289 ; 0000-0002-4715-6454 ; 0000-0002-3623-236X ; 0000-0003-1111-0283 ; 0000-0002-9370-2671 ; 0000-0003-3563-6546 ; 0000-0003-1523-1621 ; 0000-0002-3535-6467 ; 0000-0002-7633-9006 ; 0000-0001-6037-6972 ; 0000-0002-2682-912X ; 0000-0002-1988-6572 ; 0000-0001-7547-6423</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2871,2872,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38207030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng, Melissa S F</creatorcontrib><creatorcontrib>Kwok, Immanuel</creatorcontrib><creatorcontrib>Tan, Leonard</creatorcontrib><creatorcontrib>Shi, Changming</creatorcontrib><creatorcontrib>Cerezo-Wallis, Daniela</creatorcontrib><creatorcontrib>Tan, Yingrou</creatorcontrib><creatorcontrib>Leong, Keith</creatorcontrib><creatorcontrib>Calvo, Gabriel F</creatorcontrib><creatorcontrib>Yang, Katharine</creatorcontrib><creatorcontrib>Zhang, Yuning</creatorcontrib><creatorcontrib>Jin, Jingsi</creatorcontrib><creatorcontrib>Liong, Ka Hang</creatorcontrib><creatorcontrib>Wu, Dandan</creatorcontrib><creatorcontrib>He, Rui</creatorcontrib><creatorcontrib>Liu, Dehua</creatorcontrib><creatorcontrib>Teh, Ye Chean</creatorcontrib><creatorcontrib>Bleriot, Camille</creatorcontrib><creatorcontrib>Caronni, Nicoletta</creatorcontrib><creatorcontrib>Liu, Zhaoyuan</creatorcontrib><creatorcontrib>Duan, Kaibo</creatorcontrib><creatorcontrib>Narang, Vipin</creatorcontrib><creatorcontrib>Ballesteros, Iván</creatorcontrib><creatorcontrib>Moalli, Federica</creatorcontrib><creatorcontrib>Li, Mengwei</creatorcontrib><creatorcontrib>Chen, Jinmiao</creatorcontrib><creatorcontrib>Liu, Yao</creatorcontrib><creatorcontrib>Liu, Lianxin</creatorcontrib><creatorcontrib>Qi, Jingjing</creatorcontrib><creatorcontrib>Liu, Yingbin</creatorcontrib><creatorcontrib>Jiang, Lingxi</creatorcontrib><creatorcontrib>Shen, Baiyong</creatorcontrib><creatorcontrib>Cheng, Hui</creatorcontrib><creatorcontrib>Cheng, Tao</creatorcontrib><creatorcontrib>Angeli, Veronique</creatorcontrib><creatorcontrib>Sharma, Ankur</creatorcontrib><creatorcontrib>Loh, Yuin-Han</creatorcontrib><creatorcontrib>Tey, Hong Liang</creatorcontrib><creatorcontrib>Chong, Shu Zhen</creatorcontrib><creatorcontrib>Iannacone, Matteo</creatorcontrib><creatorcontrib>Ostuni, Renato</creatorcontrib><creatorcontrib>Hidalgo, Andrés</creatorcontrib><creatorcontrib>Ginhoux, Florent</creatorcontrib><creatorcontrib>Ng, Lai Guan</creatorcontrib><title>Deterministic reprogramming of neutrophils within tumors</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances characterizing the diversity of neutrophil states in cancer, common trajectories and mechanisms governing the ontogeny and relationship between these neutrophil states remain undefined. Here, we demonstrate that immature and mature neutrophils that enter tumors undergo irreversible epigenetic, transcriptional, and proteomic modifications to converge into a distinct, terminally differentiated dcTRAIL-R1
state. Reprogrammed dcTRAIL-R1
neutrophils predominantly localize to a glycolytic and hypoxic niche at the tumor core and exert pro-angiogenic function that favors tumor growth. We found similar trajectories in neutrophils across multiple tumor types and in humans, suggesting that targeting this program may provide a means of enhancing certain cancer immunotherapies.</description><subject>Ablation</subject><subject>Angiogenesis</subject><subject>Animal models</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Blood vessels</subject><subject>Bone marrow</subject><subject>Cancer</subject><subject>Cellular Reprogramming - genetics</subject><subject>Cellular Reprogramming - immunology</subject><subject>Chromatin</subject><subject>Convergence</subject><subject>Effector cells</subject><subject>Emergency response</subject><subject>Epigenesis, Genetic</subject><subject>Flow cytometry</subject><subject>Flow mapping</subject><subject>Gene expression</subject><subject>Gene sequencing</subject><subject>Genotype & phenotype</subject><subject>Glycolysis</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Immunotherapy</subject><subject>Individualized Instruction</subject><subject>Leukocytes (neutrophilic)</subject><subject>Life span</subject><subject>Localization</subject><subject>Maturation</subject><subject>Neoplasms - blood supply</subject><subject>Neoplasms - immunology</subject><subject>Neovascularization, Pathologic - genetics</subject><subject>Neovascularization, Pathologic - immunology</subject><subject>Neutrophils</subject><subject>Neutrophils - immunology</subject><subject>Nutrients</subject><subject>Ontogeny</subject><subject>Oxidative stress</subject><subject>Pancreatic cancer</subject><subject>Peptide mapping</subject><subject>Phenotypes</subject><subject>Populations</subject><subject>Proteomics</subject><subject>Receptors, TNF-Related Apoptosis-Inducing Ligand - immunology</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Solid tumors</subject><subject>Surface markers</subject><subject>Survival</subject><subject>Therapeutic targets</subject><subject>Transcription, Genetic</subject><subject>Tumor cells</subject><subject>Tumor microenvironment</subject><subject>Tumors</subject><subject>Vascular endothelial growth factor</subject><issn>0036-8075</issn><issn>1095-9203</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkDtPwzAUhS0EoqUws6FILCxp_Y49ovKUKrHAbLm207pK4mInQvx7XDUwMF3de757dHQAuEZwjhDmi2S864yba1tzKskJmCIoWSkxJKdgCiHhpYAVm4CLlHYQZk2SczAhAsMKEjgF4sH1Lra-86n3pohuH8Mm6jZfNkWoi84NfQz7rW9S8eX7re-KfmhDTJfgrNZNclfjnIGPp8f35Uu5ent-Xd6vSkMw60thbSUFtZIbWhmBqeM5kK245UIauiYUkbWusOQYMao5y1pehea1QYgzMgN3R98c7HNwqVetT8Y1je5cGJLCElHMIM8-M3D7D92FIXY53YEiCENGZKYWR8rEkFJ0tdpH3-r4rRBUh1LVWKoaS80fN6PvsG6d_eN_WyQ_g-JzcQ</recordid><startdate>20240112</startdate><enddate>20240112</enddate><creator>Ng, Melissa S 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reprogramming of neutrophils within tumors</title><author>Ng, Melissa S F ; Kwok, Immanuel ; Tan, Leonard ; Shi, Changming ; Cerezo-Wallis, Daniela ; Tan, Yingrou ; Leong, Keith ; Calvo, Gabriel F ; Yang, Katharine ; Zhang, Yuning ; Jin, Jingsi ; Liong, Ka Hang ; Wu, Dandan ; He, Rui ; Liu, Dehua ; Teh, Ye Chean ; Bleriot, Camille ; Caronni, Nicoletta ; Liu, Zhaoyuan ; Duan, Kaibo ; Narang, Vipin ; Ballesteros, Iván ; Moalli, Federica ; Li, Mengwei ; Chen, Jinmiao ; Liu, Yao ; Liu, Lianxin ; Qi, Jingjing ; Liu, Yingbin ; Jiang, Lingxi ; Shen, Baiyong ; Cheng, Hui ; Cheng, Tao ; Angeli, Veronique ; Sharma, Ankur ; Loh, Yuin-Han ; Tey, Hong Liang ; Chong, Shu Zhen ; Iannacone, Matteo ; Ostuni, Renato ; Hidalgo, Andrés ; Ginhoux, Florent ; Ng, Lai Guan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-8dd7984d96c47c824e6807d76d689c4b3413ba72962154a657d7a728a6fc11653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Ablation</topic><topic>Angiogenesis</topic><topic>Animal models</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>Blood vessels</topic><topic>Bone marrow</topic><topic>Cancer</topic><topic>Cellular Reprogramming - genetics</topic><topic>Cellular Reprogramming - immunology</topic><topic>Chromatin</topic><topic>Convergence</topic><topic>Effector cells</topic><topic>Emergency response</topic><topic>Epigenesis, Genetic</topic><topic>Flow cytometry</topic><topic>Flow mapping</topic><topic>Gene expression</topic><topic>Gene sequencing</topic><topic>Genotype & phenotype</topic><topic>Glycolysis</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Immunotherapy</topic><topic>Individualized Instruction</topic><topic>Leukocytes (neutrophilic)</topic><topic>Life span</topic><topic>Localization</topic><topic>Maturation</topic><topic>Neoplasms - blood supply</topic><topic>Neoplasms - immunology</topic><topic>Neovascularization, Pathologic - genetics</topic><topic>Neovascularization, Pathologic - immunology</topic><topic>Neutrophils</topic><topic>Neutrophils - immunology</topic><topic>Nutrients</topic><topic>Ontogeny</topic><topic>Oxidative stress</topic><topic>Pancreatic cancer</topic><topic>Peptide mapping</topic><topic>Phenotypes</topic><topic>Populations</topic><topic>Proteomics</topic><topic>Receptors, TNF-Related Apoptosis-Inducing Ligand - immunology</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Solid tumors</topic><topic>Surface markers</topic><topic>Survival</topic><topic>Therapeutic targets</topic><topic>Transcription, Genetic</topic><topic>Tumor cells</topic><topic>Tumor microenvironment</topic><topic>Tumors</topic><topic>Vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ng, Melissa S F</creatorcontrib><creatorcontrib>Kwok, Immanuel</creatorcontrib><creatorcontrib>Tan, Leonard</creatorcontrib><creatorcontrib>Shi, Changming</creatorcontrib><creatorcontrib>Cerezo-Wallis, Daniela</creatorcontrib><creatorcontrib>Tan, Yingrou</creatorcontrib><creatorcontrib>Leong, Keith</creatorcontrib><creatorcontrib>Calvo, Gabriel F</creatorcontrib><creatorcontrib>Yang, Katharine</creatorcontrib><creatorcontrib>Zhang, Yuning</creatorcontrib><creatorcontrib>Jin, Jingsi</creatorcontrib><creatorcontrib>Liong, Ka Hang</creatorcontrib><creatorcontrib>Wu, Dandan</creatorcontrib><creatorcontrib>He, Rui</creatorcontrib><creatorcontrib>Liu, Dehua</creatorcontrib><creatorcontrib>Teh, Ye Chean</creatorcontrib><creatorcontrib>Bleriot, Camille</creatorcontrib><creatorcontrib>Caronni, Nicoletta</creatorcontrib><creatorcontrib>Liu, Zhaoyuan</creatorcontrib><creatorcontrib>Duan, Kaibo</creatorcontrib><creatorcontrib>Narang, Vipin</creatorcontrib><creatorcontrib>Ballesteros, Iván</creatorcontrib><creatorcontrib>Moalli, Federica</creatorcontrib><creatorcontrib>Li, Mengwei</creatorcontrib><creatorcontrib>Chen, Jinmiao</creatorcontrib><creatorcontrib>Liu, Yao</creatorcontrib><creatorcontrib>Liu, Lianxin</creatorcontrib><creatorcontrib>Qi, Jingjing</creatorcontrib><creatorcontrib>Liu, Yingbin</creatorcontrib><creatorcontrib>Jiang, Lingxi</creatorcontrib><creatorcontrib>Shen, Baiyong</creatorcontrib><creatorcontrib>Cheng, Hui</creatorcontrib><creatorcontrib>Cheng, Tao</creatorcontrib><creatorcontrib>Angeli, Veronique</creatorcontrib><creatorcontrib>Sharma, Ankur</creatorcontrib><creatorcontrib>Loh, Yuin-Han</creatorcontrib><creatorcontrib>Tey, Hong Liang</creatorcontrib><creatorcontrib>Chong, Shu Zhen</creatorcontrib><creatorcontrib>Iannacone, Matteo</creatorcontrib><creatorcontrib>Ostuni, Renato</creatorcontrib><creatorcontrib>Hidalgo, Andrés</creatorcontrib><creatorcontrib>Ginhoux, Florent</creatorcontrib><creatorcontrib>Ng, Lai Guan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ng, Melissa S F</au><au>Kwok, Immanuel</au><au>Tan, Leonard</au><au>Shi, Changming</au><au>Cerezo-Wallis, Daniela</au><au>Tan, Yingrou</au><au>Leong, Keith</au><au>Calvo, Gabriel F</au><au>Yang, Katharine</au><au>Zhang, Yuning</au><au>Jin, Jingsi</au><au>Liong, Ka Hang</au><au>Wu, Dandan</au><au>He, Rui</au><au>Liu, Dehua</au><au>Teh, Ye Chean</au><au>Bleriot, Camille</au><au>Caronni, Nicoletta</au><au>Liu, Zhaoyuan</au><au>Duan, Kaibo</au><au>Narang, Vipin</au><au>Ballesteros, Iván</au><au>Moalli, Federica</au><au>Li, Mengwei</au><au>Chen, Jinmiao</au><au>Liu, Yao</au><au>Liu, Lianxin</au><au>Qi, Jingjing</au><au>Liu, Yingbin</au><au>Jiang, Lingxi</au><au>Shen, Baiyong</au><au>Cheng, Hui</au><au>Cheng, Tao</au><au>Angeli, Veronique</au><au>Sharma, Ankur</au><au>Loh, Yuin-Han</au><au>Tey, Hong Liang</au><au>Chong, Shu Zhen</au><au>Iannacone, Matteo</au><au>Ostuni, Renato</au><au>Hidalgo, Andrés</au><au>Ginhoux, Florent</au><au>Ng, Lai Guan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deterministic reprogramming of neutrophils within tumors</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2024-01-12</date><risdate>2024</risdate><volume>383</volume><issue>6679</issue><spage>eadf6493</spage><pages>eadf6493-</pages><issn>0036-8075</issn><issn>1095-9203</issn><eissn>1095-9203</eissn><abstract>Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances characterizing the diversity of neutrophil states in cancer, common trajectories and mechanisms governing the ontogeny and relationship between these neutrophil states remain undefined. Here, we demonstrate that immature and mature neutrophils that enter tumors undergo irreversible epigenetic, transcriptional, and proteomic modifications to converge into a distinct, terminally differentiated dcTRAIL-R1
state. Reprogrammed dcTRAIL-R1
neutrophils predominantly localize to a glycolytic and hypoxic niche at the tumor core and exert pro-angiogenic function that favors tumor growth. We found similar trajectories in neutrophils across multiple tumor types and in humans, suggesting that targeting this program may provide a means of enhancing certain cancer immunotherapies.</abstract><cop>United States</cop><pub>The American Association for the Advancement of Science</pub><pmid>38207030</pmid><doi>10.1126/science.adf6493</doi><orcidid>https://orcid.org/0000-0002-6862-136X</orcidid><orcidid>https://orcid.org/0000-0003-1905-3586</orcidid><orcidid>https://orcid.org/0000-0002-2857-7755</orcidid><orcidid>https://orcid.org/0000-0002-4298-2888</orcidid><orcidid>https://orcid.org/0000-0003-0155-2109</orcidid><orcidid>https://orcid.org/0000-0002-6923-1021</orcidid><orcidid>https://orcid.org/0000-0002-0568-3387</orcidid><orcidid>https://orcid.org/0009-0003-3665-3978</orcidid><orcidid>https://orcid.org/0000-0002-3994-248X</orcidid><orcidid>https://orcid.org/0000-0002-3117-0833</orcidid><orcidid>https://orcid.org/0000-0002-5925-2769</orcidid><orcidid>https://orcid.org/0000-0003-0365-3229</orcidid><orcidid>https://orcid.org/0000-0002-2759-3497</orcidid><orcidid>https://orcid.org/0000-0001-5513-555X</orcidid><orcidid>https://orcid.org/0000-0001-8894-6711</orcidid><orcidid>https://orcid.org/0000-0002-3263-7108</orcidid><orcidid>https://orcid.org/0000-0003-0460-3426</orcidid><orcidid>https://orcid.org/0000-0002-6246-2353</orcidid><orcidid>https://orcid.org/0000-0003-3826-2746</orcidid><orcidid>https://orcid.org/0000-0002-7575-032X</orcidid><orcidid>https://orcid.org/0000-0002-8209-1289</orcidid><orcidid>https://orcid.org/0000-0002-4715-6454</orcidid><orcidid>https://orcid.org/0000-0002-3623-236X</orcidid><orcidid>https://orcid.org/0000-0003-1111-0283</orcidid><orcidid>https://orcid.org/0000-0002-9370-2671</orcidid><orcidid>https://orcid.org/0000-0003-3563-6546</orcidid><orcidid>https://orcid.org/0000-0003-1523-1621</orcidid><orcidid>https://orcid.org/0000-0002-3535-6467</orcidid><orcidid>https://orcid.org/0000-0002-7633-9006</orcidid><orcidid>https://orcid.org/0000-0001-6037-6972</orcidid><orcidid>https://orcid.org/0000-0002-2682-912X</orcidid><orcidid>https://orcid.org/0000-0002-1988-6572</orcidid><orcidid>https://orcid.org/0000-0001-7547-6423</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2024-01, Vol.383 (6679), p.eadf6493 |
| issn | 0036-8075 1095-9203 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2914250641 |
| source | American Association for the Advancement of Science; MEDLINE |
| subjects | Ablation Angiogenesis Animal models Biomarkers Blood Blood vessels Bone marrow Cancer Cellular Reprogramming - genetics Cellular Reprogramming - immunology Chromatin Convergence Effector cells Emergency response Epigenesis, Genetic Flow cytometry Flow mapping Gene expression Gene sequencing Genotype & phenotype Glycolysis Growth factors Humans Hypoxia Immunotherapy Individualized Instruction Leukocytes (neutrophilic) Life span Localization Maturation Neoplasms - blood supply Neoplasms - immunology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - immunology Neutrophils Neutrophils - immunology Nutrients Ontogeny Oxidative stress Pancreatic cancer Peptide mapping Phenotypes Populations Proteomics Receptors, TNF-Related Apoptosis-Inducing Ligand - immunology Ribonucleic acid RNA Solid tumors Surface markers Survival Therapeutic targets Transcription, Genetic Tumor cells Tumor microenvironment Tumors Vascular endothelial growth factor |
| title | Deterministic reprogramming of neutrophils within tumors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T21%3A56%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Deterministic%20reprogramming%20of%20neutrophils%20within%20tumors&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Ng,%20Melissa%20S%20F&rft.date=2024-01-12&rft.volume=383&rft.issue=6679&rft.spage=eadf6493&rft.pages=eadf6493-&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.adf6493&rft_dat=%3Cproquest_cross%3E2913120539%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2913120539&rft_id=info:pmid/38207030&rfr_iscdi=true |