Single-cell, single-nucleus, and spatial transcriptomics characterization of the immunological landscape in the healthy and PSC human liver

Primary sclerosing cholangitis (PSC) is an immune-mediated cholestatic liver disease for which there is an unmet need to understand the cellular composition of the affected liver and how it underlies disease pathogenesis. We aimed to generate a comprehensive atlas of the PSC liver using multi-omic m...

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Veröffentlicht in:	Journal of hepatology 2024-05, Vol.80 (5), p.730-743
Hauptverfasser:	Andrews, Tallulah S., Nakib, Diana, Perciani, Catia T., Ma, Xue Zhong, Liu, Lewis, Winter, Erin, Camat, Damra, Chung, Sai W., Lumanto, Patricia, Manuel, Justin, Mangroo, Shantel, Hansen, Bettina, Arpinder, Bal, Thoeni, Cornelia, Sayed, Blayne, Feld, Jordan, Gehring, Adam, Gulamhusein, Aliya, Hirschfield, Gideon M., Ricciuto, Amanda, Bader, Gary D., McGilvray, Ian D., MacParland, Sonya
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholangitis, Sclerosing Cicatrix - metabolism Cicatrix - pathology Cytokines - metabolism Ecosystem Gene Expression Profiling Humans Inflammation - metabolism Liver Liver - pathology Liver Cirrhosis - pathology Myeloid Dysfunction Primary Sclerosing Cholangitis Single Cell RNA sequencing Spatial Transcriptomics
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