Fetal overgrowth and weight trajectories during infancy and adiposity in early childhood
Background Large-for-gestational age (LGA), a marker of fetal overgrowth, has been linked to obesity in adulthood. Little is known about how infancy growth trajectories affect adiposity in early childhood in LGA. Methods In the Shanghai Birth Cohort, we followed up 259 LGA (birth weight >90th per...
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| creator | Tao, Min-Yi Liu, Xin Chen, Zi-Lin Yang, Meng-Nan Xu, Ya-Jie He, Hua Fang, Fang Chen, Qian Mao, Xuan-Xia Zhang, Jun Ouyang, Fengxiu Shen, Xiu-Hua Li, Fei Luo, Zhong-Cheng Shen, Xiaoming Huang, Hong Sun, Kun Zhang, Jun Wang, Weiye Xu, Weiping Ouyang, Fengxiu Li, Fei Huang, Yin Zhang, Jinsong Yan, Chonghuai Shen, Lisong Bao, Yixiao Tian, Ying Chen, Weiwei Zhang, Huijuan Tong, Chuanliang Xu, Jian Zhang, Lin Zhang, Yiwen Jiang, Fang Yu, Xiaodan Yu, Guangjun Chen, Jinjin Zhang, Yu Li, Xiaotian Cheng, Haidong Zhang, Qinying Duan, Tao Hua, Jing Peng, Hua |
| description | Background
Large-for-gestational age (LGA), a marker of fetal overgrowth, has been linked to obesity in adulthood. Little is known about how infancy growth trajectories affect adiposity in early childhood in LGA.
Methods
In the Shanghai Birth Cohort, we followed up 259 LGA (birth weight >90th percentile) and 1673 appropriate-for-gestational age (AGA, 10th–90th percentiles) children on body composition (by InBody 770) at age 4 years. Adiposity outcomes include body fat mass (BFM), percent body fat (PBF), body mass index (BMI), overweight/obesity, and high adiposity (PBF >85th percentile).
Results
Three weight growth trajectories (low, mid, and high) during infancy (0–2 years) were identified in AGA and LGA subjects separately. BFM, PBF and BMI were progressively higher from low- to mid-to high-growth trajectories in both AGA and LGA children. Compared to the mid-growth trajectory, the high-growth trajectory was associated with greater increases in BFM and the odds of overweight/obesity or high adiposity in LGA than in AGA children (tests for interactions, all
P
|
| doi_str_mv | 10.1038/s41390-023-02991-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2913443515</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3043521025</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-3b1093d0a78d6aa8f1661d18cfd146af50da9851a78972a760edfa46c6cb56ad3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMoWqt_wIMsePGymq_Nbo5S_IKCFwVvYZpk25Ttpia7lv33ptYP8OBhGJh55k14EDoj-IpgVl1HTpjEOaYslZQkL_fQiBQsjTgv99EIY0ZyJmV1hI5jXGJMeFHxQ3TEKpp2lI3Q653toMn8uw3z4DfdIoPWZBvr5osu6wIsre58cDZmpg-unWeuraHVwycGxq19dN2QppmF0AyZXrjGLLw3J-ighiba068-Ri93t8-Th3z6dP84uZnmmlHR5WxGsGQGQ1kZAVDVRAhiSKVrQ7iAusAGZFWQtJclhVJga2rgQgs9KwQYNkaXu9x18G-9jZ1auaht00BrfR8VlYRxzorkZYwu_qBL34c2_U4xnBBKMN1SdEfp4GMMtlbr4FYQBkWw2npXO-8qeVef3lWZjs6_ovvZypqfk2_RCWA7IK63Gm34ffuf2A9Rao4F</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3043521025</pqid></control><display><type>article</type><title>Fetal overgrowth and weight trajectories during infancy and adiposity in early childhood</title><source>Springer Nature - Complete Springer Journals</source><creator>Tao, Min-Yi ; Liu, Xin ; Chen, Zi-Lin ; Yang, Meng-Nan ; Xu, Ya-Jie ; He, Hua ; Fang, Fang ; Chen, Qian ; Mao, Xuan-Xia ; Zhang, Jun ; Ouyang, Fengxiu ; Shen, Xiu-Hua ; Li, Fei ; Luo, Zhong-Cheng ; Shen, Xiaoming ; Huang, Hong ; Sun, Kun ; Zhang, Jun ; Wang, Weiye ; Xu, Weiping ; Ouyang, Fengxiu ; Li, Fei ; Huang, Yin ; Zhang, Jinsong ; Yan, Chonghuai ; Shen, Lisong ; Bao, Yixiao ; Tian, Ying ; Chen, Weiwei ; Zhang, Huijuan ; Tong, Chuanliang ; Xu, Jian ; Zhang, Lin ; Zhang, Yiwen ; Jiang, Fang ; Yu, Xiaodan ; Yu, Guangjun ; Chen, Jinjin ; Zhang, Yu ; Li, Xiaotian ; Cheng, Haidong ; Zhang, Qinying ; Duan, Tao ; Hua, Jing ; Peng, Hua</creator><creatorcontrib>Tao, Min-Yi ; Liu, Xin ; Chen, Zi-Lin ; Yang, Meng-Nan ; Xu, Ya-Jie ; He, Hua ; Fang, Fang ; Chen, Qian ; Mao, Xuan-Xia ; Zhang, Jun ; Ouyang, Fengxiu ; Shen, Xiu-Hua ; Li, Fei ; Luo, Zhong-Cheng ; Shen, Xiaoming ; Huang, Hong ; Sun, Kun ; Zhang, Jun ; Wang, Weiye ; Xu, Weiping ; Ouyang, Fengxiu ; Li, Fei ; Huang, Yin ; Zhang, Jinsong ; Yan, Chonghuai ; Shen, Lisong ; Bao, Yixiao ; Tian, Ying ; Chen, Weiwei ; Zhang, Huijuan ; Tong, Chuanliang ; Xu, Jian ; Zhang, Lin ; Zhang, Yiwen ; Jiang, Fang ; Yu, Xiaodan ; Yu, Guangjun ; Chen, Jinjin ; Zhang, Yu ; Li, Xiaotian ; Cheng, Haidong ; Zhang, Qinying ; Duan, Tao ; Hua, Jing ; Peng, Hua ; Shanghai Birth Cohort ; for the Shanghai Birth Cohort</creatorcontrib><description>Background
Large-for-gestational age (LGA), a marker of fetal overgrowth, has been linked to obesity in adulthood. Little is known about how infancy growth trajectories affect adiposity in early childhood in LGA.
Methods
In the Shanghai Birth Cohort, we followed up 259 LGA (birth weight >90th percentile) and 1673 appropriate-for-gestational age (AGA, 10th–90th percentiles) children on body composition (by InBody 770) at age 4 years. Adiposity outcomes include body fat mass (BFM), percent body fat (PBF), body mass index (BMI), overweight/obesity, and high adiposity (PBF >85th percentile).
Results
Three weight growth trajectories (low, mid, and high) during infancy (0–2 years) were identified in AGA and LGA subjects separately. BFM, PBF and BMI were progressively higher from low- to mid-to high-growth trajectories in both AGA and LGA children. Compared to the mid-growth trajectory, the high-growth trajectory was associated with greater increases in BFM and the odds of overweight/obesity or high adiposity in LGA than in AGA children (tests for interactions, all
P
< 0.05).
Conclusions
Weight trajectories during infancy affect adiposity in early childhood regardless of LGA or not. The study is the first to demonstrate that high-growth weight trajectory during infancy has a greater impact on adiposity in early childhood in LGA than in AGA subjects.
Impact
Large-for-gestational age (LGA), a marker of fetal overgrowth, has been linked to obesity in adulthood, but little is known about how weight trajectories during infancy affect adiposity during early childhood in LGA subjects.
The study is the first to demonstrate a greater impact of high-growth weight trajectory during infancy (0–2 years) on adiposity in early childhood (at age 4 years) in subjects with fetal overgrowth (LGA) than in those with normal birth size (appropriate-for-gestational age).
Weight trajectory monitoring may be a valuable tool in identifying high-risk LGA children for close follow-ups and interventions to decrease the risk of obesity.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-023-02991-7</identifier><identifier>PMID: 38200323</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Body fat ; Body mass index ; Childhood ; Childrens health ; Disease prevention ; Gestational age ; Medicine ; Medicine & Public Health ; Obesity ; Overweight ; Pediatric Surgery ; Pediatrics ; Population Study Article</subject><ispartof>Pediatric research, 2024-04, Vol.95 (5), p.1372-1378</ispartof><rights>The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-3b1093d0a78d6aa8f1661d18cfd146af50da9851a78972a760edfa46c6cb56ad3</cites><orcidid>0000-0002-1794-1312</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41390-023-02991-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41390-023-02991-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38200323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tao, Min-Yi</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Chen, Zi-Lin</creatorcontrib><creatorcontrib>Yang, Meng-Nan</creatorcontrib><creatorcontrib>Xu, Ya-Jie</creatorcontrib><creatorcontrib>He, Hua</creatorcontrib><creatorcontrib>Fang, Fang</creatorcontrib><creatorcontrib>Chen, Qian</creatorcontrib><creatorcontrib>Mao, Xuan-Xia</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Ouyang, Fengxiu</creatorcontrib><creatorcontrib>Shen, Xiu-Hua</creatorcontrib><creatorcontrib>Li, Fei</creatorcontrib><creatorcontrib>Luo, Zhong-Cheng</creatorcontrib><creatorcontrib>Shen, Xiaoming</creatorcontrib><creatorcontrib>Huang, Hong</creatorcontrib><creatorcontrib>Sun, Kun</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Wang, Weiye</creatorcontrib><creatorcontrib>Xu, Weiping</creatorcontrib><creatorcontrib>Ouyang, Fengxiu</creatorcontrib><creatorcontrib>Li, Fei</creatorcontrib><creatorcontrib>Huang, Yin</creatorcontrib><creatorcontrib>Zhang, Jinsong</creatorcontrib><creatorcontrib>Yan, Chonghuai</creatorcontrib><creatorcontrib>Shen, Lisong</creatorcontrib><creatorcontrib>Bao, Yixiao</creatorcontrib><creatorcontrib>Tian, Ying</creatorcontrib><creatorcontrib>Chen, Weiwei</creatorcontrib><creatorcontrib>Zhang, Huijuan</creatorcontrib><creatorcontrib>Tong, Chuanliang</creatorcontrib><creatorcontrib>Xu, Jian</creatorcontrib><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Zhang, Yiwen</creatorcontrib><creatorcontrib>Jiang, Fang</creatorcontrib><creatorcontrib>Yu, Xiaodan</creatorcontrib><creatorcontrib>Yu, Guangjun</creatorcontrib><creatorcontrib>Chen, Jinjin</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Li, Xiaotian</creatorcontrib><creatorcontrib>Cheng, Haidong</creatorcontrib><creatorcontrib>Zhang, Qinying</creatorcontrib><creatorcontrib>Duan, Tao</creatorcontrib><creatorcontrib>Hua, Jing</creatorcontrib><creatorcontrib>Peng, Hua</creatorcontrib><creatorcontrib>Shanghai Birth Cohort</creatorcontrib><creatorcontrib>for the Shanghai Birth Cohort</creatorcontrib><title>Fetal overgrowth and weight trajectories during infancy and adiposity in early childhood</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
Large-for-gestational age (LGA), a marker of fetal overgrowth, has been linked to obesity in adulthood. Little is known about how infancy growth trajectories affect adiposity in early childhood in LGA.
Methods
In the Shanghai Birth Cohort, we followed up 259 LGA (birth weight >90th percentile) and 1673 appropriate-for-gestational age (AGA, 10th–90th percentiles) children on body composition (by InBody 770) at age 4 years. Adiposity outcomes include body fat mass (BFM), percent body fat (PBF), body mass index (BMI), overweight/obesity, and high adiposity (PBF >85th percentile).
Results
Three weight growth trajectories (low, mid, and high) during infancy (0–2 years) were identified in AGA and LGA subjects separately. BFM, PBF and BMI were progressively higher from low- to mid-to high-growth trajectories in both AGA and LGA children. Compared to the mid-growth trajectory, the high-growth trajectory was associated with greater increases in BFM and the odds of overweight/obesity or high adiposity in LGA than in AGA children (tests for interactions, all
P
< 0.05).
Conclusions
Weight trajectories during infancy affect adiposity in early childhood regardless of LGA or not. The study is the first to demonstrate that high-growth weight trajectory during infancy has a greater impact on adiposity in early childhood in LGA than in AGA subjects.
Impact
Large-for-gestational age (LGA), a marker of fetal overgrowth, has been linked to obesity in adulthood, but little is known about how weight trajectories during infancy affect adiposity during early childhood in LGA subjects.
The study is the first to demonstrate a greater impact of high-growth weight trajectory during infancy (0–2 years) on adiposity in early childhood (at age 4 years) in subjects with fetal overgrowth (LGA) than in those with normal birth size (appropriate-for-gestational age).
Weight trajectory monitoring may be a valuable tool in identifying high-risk LGA children for close follow-ups and interventions to decrease the risk of obesity.</description><subject>Body fat</subject><subject>Body mass index</subject><subject>Childhood</subject><subject>Childrens health</subject><subject>Disease prevention</subject><subject>Gestational age</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Population Study Article</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoWqt_wIMsePGymq_Nbo5S_IKCFwVvYZpk25Ttpia7lv33ptYP8OBhGJh55k14EDoj-IpgVl1HTpjEOaYslZQkL_fQiBQsjTgv99EIY0ZyJmV1hI5jXGJMeFHxQ3TEKpp2lI3Q653toMn8uw3z4DfdIoPWZBvr5osu6wIsre58cDZmpg-unWeuraHVwycGxq19dN2QppmF0AyZXrjGLLw3J-ighiba068-Ri93t8-Th3z6dP84uZnmmlHR5WxGsGQGQ1kZAVDVRAhiSKVrQ7iAusAGZFWQtJclhVJga2rgQgs9KwQYNkaXu9x18G-9jZ1auaht00BrfR8VlYRxzorkZYwu_qBL34c2_U4xnBBKMN1SdEfp4GMMtlbr4FYQBkWw2npXO-8qeVef3lWZjs6_ovvZypqfk2_RCWA7IK63Gm34ffuf2A9Rao4F</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Tao, Min-Yi</creator><creator>Liu, Xin</creator><creator>Chen, Zi-Lin</creator><creator>Yang, Meng-Nan</creator><creator>Xu, Ya-Jie</creator><creator>He, Hua</creator><creator>Fang, Fang</creator><creator>Chen, Qian</creator><creator>Mao, Xuan-Xia</creator><creator>Zhang, Jun</creator><creator>Ouyang, Fengxiu</creator><creator>Shen, Xiu-Hua</creator><creator>Li, Fei</creator><creator>Luo, Zhong-Cheng</creator><creator>Shen, Xiaoming</creator><creator>Huang, Hong</creator><creator>Sun, Kun</creator><creator>Zhang, Jun</creator><creator>Wang, Weiye</creator><creator>Xu, Weiping</creator><creator>Ouyang, Fengxiu</creator><creator>Li, Fei</creator><creator>Huang, Yin</creator><creator>Zhang, Jinsong</creator><creator>Yan, Chonghuai</creator><creator>Shen, Lisong</creator><creator>Bao, Yixiao</creator><creator>Tian, Ying</creator><creator>Chen, Weiwei</creator><creator>Zhang, Huijuan</creator><creator>Tong, Chuanliang</creator><creator>Xu, Jian</creator><creator>Zhang, Lin</creator><creator>Zhang, Yiwen</creator><creator>Jiang, Fang</creator><creator>Yu, Xiaodan</creator><creator>Yu, Guangjun</creator><creator>Chen, Jinjin</creator><creator>Zhang, Yu</creator><creator>Li, Xiaotian</creator><creator>Cheng, Haidong</creator><creator>Zhang, Qinying</creator><creator>Duan, Tao</creator><creator>Hua, Jing</creator><creator>Peng, Hua</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1794-1312</orcidid></search><sort><creationdate>20240401</creationdate><title>Fetal overgrowth and weight trajectories during infancy and adiposity in early childhood</title><author>Tao, Min-Yi ; Liu, Xin ; Chen, Zi-Lin ; Yang, Meng-Nan ; Xu, Ya-Jie ; He, Hua ; Fang, Fang ; Chen, Qian ; Mao, Xuan-Xia ; Zhang, Jun ; Ouyang, Fengxiu ; Shen, Xiu-Hua ; Li, Fei ; Luo, Zhong-Cheng ; Shen, Xiaoming ; Huang, Hong ; Sun, Kun ; Zhang, Jun ; Wang, Weiye ; Xu, Weiping ; Ouyang, Fengxiu ; Li, Fei ; Huang, Yin ; Zhang, Jinsong ; Yan, Chonghuai ; Shen, Lisong ; Bao, Yixiao ; Tian, Ying ; Chen, Weiwei ; Zhang, Huijuan ; Tong, Chuanliang ; Xu, Jian ; Zhang, Lin ; Zhang, Yiwen ; Jiang, Fang ; Yu, Xiaodan ; Yu, Guangjun ; Chen, Jinjin ; Zhang, Yu ; Li, Xiaotian ; Cheng, Haidong ; Zhang, Qinying ; Duan, Tao ; Hua, Jing ; Peng, Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-3b1093d0a78d6aa8f1661d18cfd146af50da9851a78972a760edfa46c6cb56ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Body fat</topic><topic>Body mass index</topic><topic>Childhood</topic><topic>Childrens health</topic><topic>Disease prevention</topic><topic>Gestational age</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Population Study Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tao, Min-Yi</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Chen, 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Chonghuai</creatorcontrib><creatorcontrib>Shen, Lisong</creatorcontrib><creatorcontrib>Bao, Yixiao</creatorcontrib><creatorcontrib>Tian, Ying</creatorcontrib><creatorcontrib>Chen, Weiwei</creatorcontrib><creatorcontrib>Zhang, Huijuan</creatorcontrib><creatorcontrib>Tong, Chuanliang</creatorcontrib><creatorcontrib>Xu, Jian</creatorcontrib><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Zhang, Yiwen</creatorcontrib><creatorcontrib>Jiang, Fang</creatorcontrib><creatorcontrib>Yu, Xiaodan</creatorcontrib><creatorcontrib>Yu, Guangjun</creatorcontrib><creatorcontrib>Chen, Jinjin</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Li, Xiaotian</creatorcontrib><creatorcontrib>Cheng, Haidong</creatorcontrib><creatorcontrib>Zhang, Qinying</creatorcontrib><creatorcontrib>Duan, Tao</creatorcontrib><creatorcontrib>Hua, Jing</creatorcontrib><creatorcontrib>Peng, Hua</creatorcontrib><creatorcontrib>Shanghai Birth Cohort</creatorcontrib><creatorcontrib>for the Shanghai Birth Cohort</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tao, Min-Yi</au><au>Liu, Xin</au><au>Chen, Zi-Lin</au><au>Yang, Meng-Nan</au><au>Xu, Ya-Jie</au><au>He, Hua</au><au>Fang, Fang</au><au>Chen, Qian</au><au>Mao, Xuan-Xia</au><au>Zhang, Jun</au><au>Ouyang, Fengxiu</au><au>Shen, Xiu-Hua</au><au>Li, Fei</au><au>Luo, Zhong-Cheng</au><au>Shen, Xiaoming</au><au>Huang, Hong</au><au>Sun, Kun</au><au>Zhang, Jun</au><au>Wang, Weiye</au><au>Xu, Weiping</au><au>Ouyang, Fengxiu</au><au>Li, Fei</au><au>Huang, Yin</au><au>Zhang, Jinsong</au><au>Yan, Chonghuai</au><au>Shen, Lisong</au><au>Bao, Yixiao</au><au>Tian, Ying</au><au>Chen, Weiwei</au><au>Zhang, Huijuan</au><au>Tong, Chuanliang</au><au>Xu, Jian</au><au>Zhang, Lin</au><au>Zhang, Yiwen</au><au>Jiang, Fang</au><au>Yu, Xiaodan</au><au>Yu, Guangjun</au><au>Chen, Jinjin</au><au>Zhang, Yu</au><au>Li, Xiaotian</au><au>Cheng, Haidong</au><au>Zhang, Qinying</au><au>Duan, Tao</au><au>Hua, Jing</au><au>Peng, Hua</au><aucorp>Shanghai Birth Cohort</aucorp><aucorp>for the Shanghai Birth Cohort</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal overgrowth and weight trajectories during infancy and adiposity in early childhood</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>95</volume><issue>5</issue><spage>1372</spage><epage>1378</epage><pages>1372-1378</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
Large-for-gestational age (LGA), a marker of fetal overgrowth, has been linked to obesity in adulthood. Little is known about how infancy growth trajectories affect adiposity in early childhood in LGA.
Methods
In the Shanghai Birth Cohort, we followed up 259 LGA (birth weight >90th percentile) and 1673 appropriate-for-gestational age (AGA, 10th–90th percentiles) children on body composition (by InBody 770) at age 4 years. Adiposity outcomes include body fat mass (BFM), percent body fat (PBF), body mass index (BMI), overweight/obesity, and high adiposity (PBF >85th percentile).
Results
Three weight growth trajectories (low, mid, and high) during infancy (0–2 years) were identified in AGA and LGA subjects separately. BFM, PBF and BMI were progressively higher from low- to mid-to high-growth trajectories in both AGA and LGA children. Compared to the mid-growth trajectory, the high-growth trajectory was associated with greater increases in BFM and the odds of overweight/obesity or high adiposity in LGA than in AGA children (tests for interactions, all
P
< 0.05).
Conclusions
Weight trajectories during infancy affect adiposity in early childhood regardless of LGA or not. The study is the first to demonstrate that high-growth weight trajectory during infancy has a greater impact on adiposity in early childhood in LGA than in AGA subjects.
Impact
Large-for-gestational age (LGA), a marker of fetal overgrowth, has been linked to obesity in adulthood, but little is known about how weight trajectories during infancy affect adiposity during early childhood in LGA subjects.
The study is the first to demonstrate a greater impact of high-growth weight trajectory during infancy (0–2 years) on adiposity in early childhood (at age 4 years) in subjects with fetal overgrowth (LGA) than in those with normal birth size (appropriate-for-gestational age).
Weight trajectory monitoring may be a valuable tool in identifying high-risk LGA children for close follow-ups and interventions to decrease the risk of obesity.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>38200323</pmid><doi>10.1038/s41390-023-02991-7</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1794-1312</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3998 |
| ispartof | Pediatric research, 2024-04, Vol.95 (5), p.1372-1378 |
| issn | 0031-3998 1530-0447 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2913443515 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Body fat Body mass index Childhood Childrens health Disease prevention Gestational age Medicine Medicine & Public Health Obesity Overweight Pediatric Surgery Pediatrics Population Study Article |
| title | Fetal overgrowth and weight trajectories during infancy and adiposity in early childhood |
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