TIE2 expression in hypertensive ICH and its therapeutic modulation with AKB-9778: Implications for brain vascular health

Hypertensive intracerebral hemorrhage (ICH) is a devastating condition, the molecular underpinnings of which remain not fully understood. By leveraging high-throughput transcriptome sequencing and network pharmacology analysis, this study unveils the significant role of the tyrosine kinase with immu...

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Veröffentlicht in:	Experimental neurology 2024-04, Vol.374, p.114685-114685, Article 114685
Hauptverfasser:	Wu, Jingkun, Wang, Hongbin, Wang, Naizhu, Wang, Zai, Zhu, Qinghua
Format:	Artikel
Sprache:	eng
Schlagworte:	AKB-9778 Angiogenesis Aniline Compounds Animals Brain - metabolism Brain microvascular endothelial cells Cerebral Hemorrhage - metabolism Endothelial Cells - metabolism Humans Hypertensive intracerebral hemorrhage Intracranial Hemorrhage, Hypertensive - metabolism Mice Rap1/MEK/ERK Receptor, TIE-2 - genetics Receptor, TIE-2 - metabolism Sulfonic Acids TIE2
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