Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1

PROTAC linker design remains mostly an empirical task. We employed the PRosettaC computational software in the design of sulfonyl‐fluoride‐based PROTACs targeting acyl protein thioesterase 1 (APT1). The software efficiently generated ternary complex models from empirically‐designed PROTACs and sugge...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2024-02, Vol.25 (4), p.e202300736-n/a
Hauptverfasser:	Carvalho, Luís A. R., Sousa, Bárbara B., Zaidman, Daniel, Kiely‐Collins, Hannah, Bernardes, Gonçalo J. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activity-based Protein Profiling Bioinformatics Click chemistry Design Empirical analysis PROTACs Proteins Proteomics Software Thioesterase Western blotting
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