The Transplantation of 3-Dimensional Spheroids of Adipose-Derived Stem Cells Promotes Achilles Tendon Healing in Rabbits by Enhancing the Proliferation of Tenocytes and Suppressing M1 Macrophages

Background: Tendons have limited regenerative potential, so healing of ruptured tendon tissue requires a prolonged period, and the prognosis is suboptimal. Although stem cell transplantation–based approaches show promise for accelerating tendon repair, the resultant therapeutic efficacy remains unsa...

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Veröffentlicht in:	The American journal of sports medicine 2024-02, Vol.52 (2), p.406-422
Hauptverfasser:	Chen, Shih-Heng, Lee, Yun-Wei, Kao, Huang-Kai, Yang, Pei-Ching, Chen, Shih-Hsien, Liu, Shao-Wen, Lin, Yu-Jie, Huang, Chieh-Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Achilles Tendon - pathology Adipose Tissue - pathology Animals Cell Proliferation Cytokines Gene expression Kinases Macrophages - pathology Rabbits Spheroids Stem cell transplantation Stem cells Stem Cells - physiology Tendon Injuries - surgery Tendons Tenocytes
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