The emergence of natural products as potential therapeutics for male infertility
Infertility is a major reproductive health problem. Approximately 50% of all documented cases of infertility are attributable to male factors, such as poor testicular function and semen quality. The recent significant global decline in sperm counts has serious implications for male fertility, but th...
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| Veröffentlicht in: | Andrology (Oxford) 2024-09, Vol.12 (6), p.1191-1208 |
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| creator | Li, Xiuyun Zhang, Bin Yang, Huijun Zhang, Liuping Lou, Hongxiang Zheng, Shicun |
| description | Infertility is a major reproductive health problem. Approximately 50% of all documented cases of infertility are attributable to male factors, such as poor testicular function and semen quality. The recent significant global decline in sperm counts has serious implications for male fertility, but the armamentarium for improving testicular function and semen quality is limited. Natural products have a wide range of activities and are a major source of drugs for disease prevention and treatment. To provide ideas and a theoretical basis for the research and development of therapeutic drugs for male infertility, this review summarizes natural products (mostly monomers) that have been shown to improve testicular function and semen quality and their possible mechanisms of action. These natural products primarily improve testicular function and semen quality via antioxidant, antiapoptotic, and anti‐inflammatory effects, in addition to increasing serum testosterone and reducing DNA damage in spermatozoa and testicular cells. Prospects for the application of natural products in the treatment of male infertility are discussed. |
| doi_str_mv | 10.1111/andr.13588 |
| format | Article |
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Approximately 50% of all documented cases of infertility are attributable to male factors, such as poor testicular function and semen quality. The recent significant global decline in sperm counts has serious implications for male fertility, but the armamentarium for improving testicular function and semen quality is limited. Natural products have a wide range of activities and are a major source of drugs for disease prevention and treatment. To provide ideas and a theoretical basis for the research and development of therapeutic drugs for male infertility, this review summarizes natural products (mostly monomers) that have been shown to improve testicular function and semen quality and their possible mechanisms of action. These natural products primarily improve testicular function and semen quality via antioxidant, antiapoptotic, and anti‐inflammatory effects, in addition to increasing serum testosterone and reducing DNA damage in spermatozoa and testicular cells. 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Approximately 50% of all documented cases of infertility are attributable to male factors, such as poor testicular function and semen quality. The recent significant global decline in sperm counts has serious implications for male fertility, but the armamentarium for improving testicular function and semen quality is limited. Natural products have a wide range of activities and are a major source of drugs for disease prevention and treatment. To provide ideas and a theoretical basis for the research and development of therapeutic drugs for male infertility, this review summarizes natural products (mostly monomers) that have been shown to improve testicular function and semen quality and their possible mechanisms of action. These natural products primarily improve testicular function and semen quality via antioxidant, antiapoptotic, and anti‐inflammatory effects, in addition to increasing serum testosterone and reducing DNA damage in spermatozoa and testicular cells. Prospects for the application of natural products in the treatment of male infertility are discussed.</description><subject>Animals</subject><subject>Biological Products - therapeutic use</subject><subject>Humans</subject><subject>Infertility</subject><subject>Infertility, Male - drug therapy</subject><subject>Male</subject><subject>male infertility</subject><subject>Natural products</subject><subject>reproduction</subject><subject>Semen Analysis</subject><subject>semen quality</subject><subject>Spermatozoa - drug effects</subject><subject>testicular function</subject><subject>Testis - drug effects</subject><subject>Testis - metabolism</subject><issn>2047-2919</issn><issn>2047-2927</issn><issn>2047-2927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLQzEQhYMoVmo3_gAJuBGhNY9709xl8Q1FReo6pMnE3nIfNclF-u9Nbe3ChcPADMPH4cxB6IySEU11rRvrR5TnUh6gE0ay8ZAVbHy432nRQ4MQliSV3DQ7Rj0uaUGZyE_Q62wBGGrwH9AYwK3DjY6d1xVe-dZ2JgasA161EZpYpmtcgNcr6GJpAnatx7WuAJeNAx_LqozrU3TkdBVgsJt99H5_N7t5HE5fHp5uJtOh4QWXQxCcE-IAGONEWxAsyw2AJrmxRs5tTp3QItOucFY7qbnNmM0FnedmbtNTvI8ut7rJ52cHIaq6DAaqSjfQdkGlz1nOBCUyoRd_0GXb-Sa5U5wUTIyFkFmirraU8W0IHpxa-bLWfq0oUZuo1SZq9RN1gs93kt28BrtHf4NNAN0CX2UF63-k1OT59m0r-g3294ml</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Li, Xiuyun</creator><creator>Zhang, Bin</creator><creator>Yang, Huijun</creator><creator>Zhang, Liuping</creator><creator>Lou, Hongxiang</creator><creator>Zheng, Shicun</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2345-9039</orcidid></search><sort><creationdate>202409</creationdate><title>The emergence of natural products as potential therapeutics for male infertility</title><author>Li, Xiuyun ; Zhang, Bin ; Yang, Huijun ; Zhang, Liuping ; Lou, Hongxiang ; Zheng, Shicun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3938-e63300fee2230ade6245ceea05cdc8bd51f6a64af9fdaf8a3d42d561b5cbd9193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Biological Products - therapeutic use</topic><topic>Humans</topic><topic>Infertility</topic><topic>Infertility, Male - drug therapy</topic><topic>Male</topic><topic>male infertility</topic><topic>Natural products</topic><topic>reproduction</topic><topic>Semen Analysis</topic><topic>semen quality</topic><topic>Spermatozoa - drug effects</topic><topic>testicular function</topic><topic>Testis - drug effects</topic><topic>Testis - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xiuyun</creatorcontrib><creatorcontrib>Zhang, Bin</creatorcontrib><creatorcontrib>Yang, Huijun</creatorcontrib><creatorcontrib>Zhang, Liuping</creatorcontrib><creatorcontrib>Lou, Hongxiang</creatorcontrib><creatorcontrib>Zheng, Shicun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Andrology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xiuyun</au><au>Zhang, Bin</au><au>Yang, Huijun</au><au>Zhang, Liuping</au><au>Lou, Hongxiang</au><au>Zheng, Shicun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The emergence of natural products as potential therapeutics for male infertility</atitle><jtitle>Andrology (Oxford)</jtitle><addtitle>Andrology</addtitle><date>2024-09</date><risdate>2024</risdate><volume>12</volume><issue>6</issue><spage>1191</spage><epage>1208</epage><pages>1191-1208</pages><issn>2047-2919</issn><issn>2047-2927</issn><eissn>2047-2927</eissn><abstract>Infertility is a major reproductive health problem. Approximately 50% of all documented cases of infertility are attributable to male factors, such as poor testicular function and semen quality. The recent significant global decline in sperm counts has serious implications for male fertility, but the armamentarium for improving testicular function and semen quality is limited. Natural products have a wide range of activities and are a major source of drugs for disease prevention and treatment. To provide ideas and a theoretical basis for the research and development of therapeutic drugs for male infertility, this review summarizes natural products (mostly monomers) that have been shown to improve testicular function and semen quality and their possible mechanisms of action. These natural products primarily improve testicular function and semen quality via antioxidant, antiapoptotic, and anti‐inflammatory effects, in addition to increasing serum testosterone and reducing DNA damage in spermatozoa and testicular cells. Prospects for the application of natural products in the treatment of male infertility are discussed.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38191265</pmid><doi>10.1111/andr.13588</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-2345-9039</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biological Products - therapeutic use Humans Infertility Infertility, Male - drug therapy Male male infertility Natural products reproduction Semen Analysis semen quality Spermatozoa - drug effects testicular function Testis - drug effects Testis - metabolism |
| title | The emergence of natural products as potential therapeutics for male infertility |
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