Artificial intelligence-driven design of the assembled major cat allergen Fel d 1 to improve its spatial folding and IgE-reactivity

•We firstly provided an AI-design strategy to optimize the Fel d 1 with improved spatial conformation between two chains.•The optimized Fel d 1 could fold into its native-like structure with no extra process and its IgE-binding activity was improved.•The strategy lays the foundation for the Fel d 1&...

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Veröffentlicht in:	International immunopharmacology 2024-02, Vol.128, p.111488-111488, Article 111488
Hauptverfasser:	Zheng, Wei, Xu, Yi-Fei, Hu, Zhi-Ming, Li, Ke, Xu, Zhi-Qiang, Sun, Jin-Lyu, Wei, Ji-Fu
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergen Artificial intelligence Escherichia coli Fel d 1 Immunoglobulin E (IgE)
Online-Zugang:	Volltext
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