Studying serum neurofilament light chain levels as a potential new biomarker for small fiber neuropathy
Background and purpose Diagnosing small fiber neuropathies can be challenging. To address this issue, whether serum neurofilament light chain (sNfL) could serve as a potential biomarker of damage to epidermal Aδ‐ and C‐fibers was tested. Methods Serum NfL levels were assessed in 30 patients diagnose...
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| Veröffentlicht in: | European journal of neurology 2024-04, Vol.31 (4), p.e16192-n/a |
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| container_title | European journal of neurology |
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| creator | Baka, Panoraia Steenken, Livia Escolano‐Lozano, Fabiola Steffen, Falk Papagianni, Aikaterini Sommer, Claudia Pogatzki‐Zahn, Esther Hirsch, Silke Protopapa, Maria Bittner, Stefan Birklein, Frank |
| description | Background and purpose
Diagnosing small fiber neuropathies can be challenging. To address this issue, whether serum neurofilament light chain (sNfL) could serve as a potential biomarker of damage to epidermal Aδ‐ and C‐fibers was tested.
Methods
Serum NfL levels were assessed in 30 patients diagnosed with small fiber neuropathy and were compared to a control group of 19 healthy individuals. Electrophysiological studies, quantitative sensory testing and quantification of intraepidermal nerve fiber density after skin biopsy were performed in both the proximal and distal leg.
Results
Serum NfL levels were not increased in patients with small fiber neuropathy compared to healthy controls (9.1 ± 3.9 and 9.4 ± 3.8, p = 0.83) and did not correlate with intraepidermal nerve fiber density at the lateral calf or lateral thigh or with other parameters of small fiber impairment.
Conclusion
Serum NfL levels cannot serve as a biomarker for small fiber damage. |
| doi_str_mv | 10.1111/ene.16192 |
| format | Article |
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Diagnosing small fiber neuropathies can be challenging. To address this issue, whether serum neurofilament light chain (sNfL) could serve as a potential biomarker of damage to epidermal Aδ‐ and C‐fibers was tested.
Methods
Serum NfL levels were assessed in 30 patients diagnosed with small fiber neuropathy and were compared to a control group of 19 healthy individuals. Electrophysiological studies, quantitative sensory testing and quantification of intraepidermal nerve fiber density after skin biopsy were performed in both the proximal and distal leg.
Results
Serum NfL levels were not increased in patients with small fiber neuropathy compared to healthy controls (9.1 ± 3.9 and 9.4 ± 3.8, p = 0.83) and did not correlate with intraepidermal nerve fiber density at the lateral calf or lateral thigh or with other parameters of small fiber impairment.
Conclusion
Serum NfL levels cannot serve as a biomarker for small fiber damage.</description><identifier>ISSN: 1351-5101</identifier><identifier>ISSN: 1468-1331</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/ene.16192</identifier><identifier>PMID: 38189534</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Age ; axonal degeneration ; biomarker ; Biomarkers ; Biopsy ; Chronic illnesses ; Damage ; Density ; Diabetes ; Diabetic neuropathy ; Epidermis - innervation ; Epidermis - pathology ; Fibers ; Humans ; Intermediate Filaments ; intraepidermal nerve fiber density ; Light levels ; Nerve Fibers - pathology ; Nerves ; Neuropathy ; Older people ; Pain ; Pathophysiology ; Peripheral Nervous System Diseases - diagnosis ; Sensory testing ; serum neurofilament light chain ; Skin ; Skin - pathology ; small fiber neuropathy ; Small Fiber Neuropathy - pathology ; Thigh</subject><ispartof>European journal of neurology, 2024-04, Vol.31 (4), p.e16192-n/a</ispartof><rights>2024 The Authors. published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.</rights><rights>2024 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3032-d199afdfac1d7b05ac54a0bec5f4c6e4a8ec44cd89ee72f5c1b9dbaa2de63bae3</citedby><cites>FETCH-LOGICAL-c3032-d199afdfac1d7b05ac54a0bec5f4c6e4a8ec44cd89ee72f5c1b9dbaa2de63bae3</cites><orcidid>0000-0002-6303-3673</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fene.16192$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fene.16192$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,11542,27903,27904,45553,45554,46030,46454</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38189534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baka, Panoraia</creatorcontrib><creatorcontrib>Steenken, Livia</creatorcontrib><creatorcontrib>Escolano‐Lozano, Fabiola</creatorcontrib><creatorcontrib>Steffen, Falk</creatorcontrib><creatorcontrib>Papagianni, Aikaterini</creatorcontrib><creatorcontrib>Sommer, Claudia</creatorcontrib><creatorcontrib>Pogatzki‐Zahn, Esther</creatorcontrib><creatorcontrib>Hirsch, Silke</creatorcontrib><creatorcontrib>Protopapa, Maria</creatorcontrib><creatorcontrib>Bittner, Stefan</creatorcontrib><creatorcontrib>Birklein, Frank</creatorcontrib><title>Studying serum neurofilament light chain levels as a potential new biomarker for small fiber neuropathy</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background and purpose
Diagnosing small fiber neuropathies can be challenging. To address this issue, whether serum neurofilament light chain (sNfL) could serve as a potential biomarker of damage to epidermal Aδ‐ and C‐fibers was tested.
Methods
Serum NfL levels were assessed in 30 patients diagnosed with small fiber neuropathy and were compared to a control group of 19 healthy individuals. Electrophysiological studies, quantitative sensory testing and quantification of intraepidermal nerve fiber density after skin biopsy were performed in both the proximal and distal leg.
Results
Serum NfL levels were not increased in patients with small fiber neuropathy compared to healthy controls (9.1 ± 3.9 and 9.4 ± 3.8, p = 0.83) and did not correlate with intraepidermal nerve fiber density at the lateral calf or lateral thigh or with other parameters of small fiber impairment.
Conclusion
Serum NfL levels cannot serve as a biomarker for small fiber damage.</description><subject>Age</subject><subject>axonal degeneration</subject><subject>biomarker</subject><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Chronic illnesses</subject><subject>Damage</subject><subject>Density</subject><subject>Diabetes</subject><subject>Diabetic neuropathy</subject><subject>Epidermis - innervation</subject><subject>Epidermis - pathology</subject><subject>Fibers</subject><subject>Humans</subject><subject>Intermediate Filaments</subject><subject>intraepidermal nerve fiber density</subject><subject>Light levels</subject><subject>Nerve Fibers - pathology</subject><subject>Nerves</subject><subject>Neuropathy</subject><subject>Older people</subject><subject>Pain</subject><subject>Pathophysiology</subject><subject>Peripheral Nervous System Diseases - diagnosis</subject><subject>Sensory testing</subject><subject>serum neurofilament light chain</subject><subject>Skin</subject><subject>Skin - pathology</subject><subject>small fiber neuropathy</subject><subject>Small Fiber Neuropathy - pathology</subject><subject>Thigh</subject><issn>1351-5101</issn><issn>1468-1331</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp10EFP2zAYBmALMVFgO-wPIEtctkPAXxyn8XGqujEJbQfgHH1xPrfunKSzE6r--xnKOCBhWbItP3plv4x9BnEFaVxTT1dQgs6P2CkUZZWBlHCc9lJBpkDAjJ3FuBFC5PNcnLCZrKDSShanbHU3Tu3e9SseKUwd72kKg3UeO-pH7t1qPXKzRtdzT4_kI8c0-XYY07VDn_yON27oMPyhwO0QeOzQe25dk87PaVsc1_uP7INFH-nTy3rOHr4v7xc32e3vHz8X324zI4XMsxa0RttaNNDOG6HQqAJFQ0bZwpRUYEWmKExbaaJ5bpWBRrcNYt5SKRskec6-HHK3Yfg7URzrzkVD3mNPwxTrXANUhRBSJ3r5hm6GKfTpdUmpUig9B5XU14MyYYgxkK23waXv7msQ9VP7dWq_fm4_2YuXxKnpqH2V_-tO4PoAds7T_v2kevlreYj8Byx2kQY</recordid><startdate>202404</startdate><enddate>202404</enddate><creator>Baka, Panoraia</creator><creator>Steenken, Livia</creator><creator>Escolano‐Lozano, Fabiola</creator><creator>Steffen, Falk</creator><creator>Papagianni, Aikaterini</creator><creator>Sommer, Claudia</creator><creator>Pogatzki‐Zahn, Esther</creator><creator>Hirsch, Silke</creator><creator>Protopapa, Maria</creator><creator>Bittner, Stefan</creator><creator>Birklein, Frank</creator><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6303-3673</orcidid></search><sort><creationdate>202404</creationdate><title>Studying serum neurofilament light chain levels as a potential new biomarker for small fiber neuropathy</title><author>Baka, Panoraia ; 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Diagnosing small fiber neuropathies can be challenging. To address this issue, whether serum neurofilament light chain (sNfL) could serve as a potential biomarker of damage to epidermal Aδ‐ and C‐fibers was tested.
Methods
Serum NfL levels were assessed in 30 patients diagnosed with small fiber neuropathy and were compared to a control group of 19 healthy individuals. Electrophysiological studies, quantitative sensory testing and quantification of intraepidermal nerve fiber density after skin biopsy were performed in both the proximal and distal leg.
Results
Serum NfL levels were not increased in patients with small fiber neuropathy compared to healthy controls (9.1 ± 3.9 and 9.4 ± 3.8, p = 0.83) and did not correlate with intraepidermal nerve fiber density at the lateral calf or lateral thigh or with other parameters of small fiber impairment.
Conclusion
Serum NfL levels cannot serve as a biomarker for small fiber damage.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>38189534</pmid><doi>10.1111/ene.16192</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6303-3673</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley-Blackwell Open Access Titles; Wiley Online Library Journals Frontfile Complete; PubMed Central |
| subjects | Age axonal degeneration biomarker Biomarkers Biopsy Chronic illnesses Damage Density Diabetes Diabetic neuropathy Epidermis - innervation Epidermis - pathology Fibers Humans Intermediate Filaments intraepidermal nerve fiber density Light levels Nerve Fibers - pathology Nerves Neuropathy Older people Pain Pathophysiology Peripheral Nervous System Diseases - diagnosis Sensory testing serum neurofilament light chain Skin Skin - pathology small fiber neuropathy Small Fiber Neuropathy - pathology Thigh |
| title | Studying serum neurofilament light chain levels as a potential new biomarker for small fiber neuropathy |
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