Preparation of [1'- 13 C]citric acid as a probe in a breath test to evaluate tricarboxylic acid cycle flux
[1'- C]Citric acid (1) was efficiently prepared from dimethyl 1,3-acetonedicarboxylate in two steps as a probe for a breath test. The synthetic method was selected because of the yield and reproducibility. Compound 1 was orally administrated to rats, and the time course of the increase of CO /...
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| Veröffentlicht in: | Journal of labelled compounds & radiopharmaceuticals 2024-03, Vol.67 (3), p.86-90 |
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| Format: | Artikel |
| Sprache: | eng |
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| container_end_page | 90 |
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| container_issue | 3 |
| container_start_page | 86 |
| container_title | Journal of labelled compounds & radiopharmaceuticals |
| container_volume | 67 |
| creator | Mitome, Hidemichi Takenishi, Mieko Ono, Kumiko Kawagoe, Naoyuki Imai, Tsunehiko Sasaki, Yosuke Urita, Yoshihisa Akira, Kazuki |
| description | [1'-
C]Citric acid (1) was efficiently prepared from dimethyl 1,3-acetonedicarboxylate in two steps as a probe for a breath test. The synthetic method was selected because of the yield and reproducibility. Compound 1 was orally administrated to rats, and the time course of the increase of
CO
/
CO
ratios (Δ
CO
) in their breath was successfully followed, indicating the metabolism of 1. Thus, the
C-breath test using 1 is a promising method to evaluate tricarboxylic acid (TCA) cycle flux. |
| doi_str_mv | 10.1002/jlcr.4083 |
| format | Article |
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C]Citric acid (1) was efficiently prepared from dimethyl 1,3-acetonedicarboxylate in two steps as a probe for a breath test. The synthetic method was selected because of the yield and reproducibility. Compound 1 was orally administrated to rats, and the time course of the increase of
CO
/
CO
ratios (Δ
CO
) in their breath was successfully followed, indicating the metabolism of 1. Thus, the
C-breath test using 1 is a promising method to evaluate tricarboxylic acid (TCA) cycle flux.</description><identifier>ISSN: 0362-4803</identifier><identifier>EISSN: 1099-1344</identifier><identifier>DOI: 10.1002/jlcr.4083</identifier><identifier>PMID: 38171549</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Citric acid ; Oral administration ; Tricarboxylic acid cycle</subject><ispartof>Journal of labelled compounds & radiopharmaceuticals, 2024-03, Vol.67 (3), p.86-90</ispartof><rights>2024 John Wiley & Sons Ltd.</rights><rights>2024 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c273t-83c4fdd93a0cc41fb8f6ee100a16459444f375093e857d1bf83de33bed837a2e3</cites><orcidid>0000-0002-5839-4781</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38171549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitome, Hidemichi</creatorcontrib><creatorcontrib>Takenishi, Mieko</creatorcontrib><creatorcontrib>Ono, Kumiko</creatorcontrib><creatorcontrib>Kawagoe, Naoyuki</creatorcontrib><creatorcontrib>Imai, Tsunehiko</creatorcontrib><creatorcontrib>Sasaki, Yosuke</creatorcontrib><creatorcontrib>Urita, Yoshihisa</creatorcontrib><creatorcontrib>Akira, Kazuki</creatorcontrib><title>Preparation of [1'- 13 C]citric acid as a probe in a breath test to evaluate tricarboxylic acid cycle flux</title><title>Journal of labelled compounds & radiopharmaceuticals</title><addtitle>J Labelled Comp Radiopharm</addtitle><description>[1'-
C]Citric acid (1) was efficiently prepared from dimethyl 1,3-acetonedicarboxylate in two steps as a probe for a breath test. The synthetic method was selected because of the yield and reproducibility. Compound 1 was orally administrated to rats, and the time course of the increase of
CO
/
CO
ratios (Δ
CO
) in their breath was successfully followed, indicating the metabolism of 1. Thus, the
C-breath test using 1 is a promising method to evaluate tricarboxylic acid (TCA) cycle flux.</description><subject>Citric acid</subject><subject>Oral administration</subject><subject>Tricarboxylic acid cycle</subject><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpdkU9Lw0AQxRdRbK0e_AKy4EE9pO5mNs3mKMV_UNCDnkTCZjOLCWlSdzfSfns3tPXgaQbm94Y38wg552zKGYtv60bbqWASDsiYsyyLOAhxSMYMZnEkJIMROXGuZizMhDgmI5A85YnIxqR-tbhSVvmqa2ln6Ae_iigHOv_UlbeVpkpXJVWOKrqyXYG0akNbWFT-i3p0nvqO4o9qeuWRDgpli269afZSvdENUtP061NyZFTj8GxXJ-T94f5t_hQtXh6f53eLSMcp-EiCFqYsM1BMa8FNIc0MMdyp-Ewkwb8wkCYsA5RJWvLCSCgRoMBSQqpihAm53u4Nhr_7YDFfVk5j06gWu97lccYZz4RMREAv_6F119s2uAsUCC6TLJGButlS2nbOWTT5ylZLZTc5Z_kQQD4EkA8BBPZit7Evllj-kfuPwy9icX9V</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Mitome, Hidemichi</creator><creator>Takenishi, Mieko</creator><creator>Ono, Kumiko</creator><creator>Kawagoe, Naoyuki</creator><creator>Imai, Tsunehiko</creator><creator>Sasaki, Yosuke</creator><creator>Urita, Yoshihisa</creator><creator>Akira, Kazuki</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5839-4781</orcidid></search><sort><creationdate>20240301</creationdate><title>Preparation of [1'- 13 C]citric acid as a probe in a breath test to evaluate tricarboxylic acid cycle flux</title><author>Mitome, Hidemichi ; Takenishi, Mieko ; Ono, Kumiko ; Kawagoe, Naoyuki ; Imai, Tsunehiko ; Sasaki, Yosuke ; Urita, Yoshihisa ; Akira, Kazuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c273t-83c4fdd93a0cc41fb8f6ee100a16459444f375093e857d1bf83de33bed837a2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Citric acid</topic><topic>Oral administration</topic><topic>Tricarboxylic acid cycle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitome, Hidemichi</creatorcontrib><creatorcontrib>Takenishi, Mieko</creatorcontrib><creatorcontrib>Ono, Kumiko</creatorcontrib><creatorcontrib>Kawagoe, Naoyuki</creatorcontrib><creatorcontrib>Imai, Tsunehiko</creatorcontrib><creatorcontrib>Sasaki, Yosuke</creatorcontrib><creatorcontrib>Urita, Yoshihisa</creatorcontrib><creatorcontrib>Akira, Kazuki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitome, Hidemichi</au><au>Takenishi, Mieko</au><au>Ono, Kumiko</au><au>Kawagoe, Naoyuki</au><au>Imai, Tsunehiko</au><au>Sasaki, Yosuke</au><au>Urita, Yoshihisa</au><au>Akira, Kazuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of [1'- 13 C]citric acid as a probe in a breath test to evaluate tricarboxylic acid cycle flux</atitle><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle><addtitle>J Labelled Comp Radiopharm</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>67</volume><issue>3</issue><spage>86</spage><epage>90</epage><pages>86-90</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>[1'-
C]Citric acid (1) was efficiently prepared from dimethyl 1,3-acetonedicarboxylate in two steps as a probe for a breath test. The synthetic method was selected because of the yield and reproducibility. Compound 1 was orally administrated to rats, and the time course of the increase of
CO
/
CO
ratios (Δ
CO
) in their breath was successfully followed, indicating the metabolism of 1. Thus, the
C-breath test using 1 is a promising method to evaluate tricarboxylic acid (TCA) cycle flux.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38171549</pmid><doi>10.1002/jlcr.4083</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-5839-4781</orcidid></addata></record> |
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| identifier | ISSN: 0362-4803 |
| ispartof | Journal of labelled compounds & radiopharmaceuticals, 2024-03, Vol.67 (3), p.86-90 |
| issn | 0362-4803 1099-1344 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2910194854 |
| source | Wiley Online Library All Journals |
| subjects | Citric acid Oral administration Tricarboxylic acid cycle |
| title | Preparation of [1'- 13 C]citric acid as a probe in a breath test to evaluate tricarboxylic acid cycle flux |
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