Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase for the Formation of Longer Alkyl-Chain Olivetolic Acid Analogs and Their Antibacterial Activities

Among presently used pharmaceuticals, about 60% were developed from natural products with unique chemical diversity and biological activities. Hence, the discovery of new bioactive compounds from natural products is still important for further drug development. In addition, breakthroughs in syntheti...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2024/01/01, Vol.72(1), pp.1-10
1. Verfasser:	Morita, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Analgesics Analogs Antibacterial activity Antiemetics Bioactive compounds cannabinoid Cannabinoids Cannabis crystal structure analysis Drug development enzyme engineering Epilepsy Genes Inflammation Metabolites Natural products Secondary metabolites Substrates Tetrahydrocannabinol THC
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