CdSe/ZnS Quantum Dots Loaded Solid Lipid Nanoparticles: Novel Luminescent Nanocomposite Particles

Highly luminescent lipophilic CdSe/ZnS core-shell QDs with an emission maximum at 556 nm were synthesized. These QDs were successfully encapsulated into solid lipid nanoparticles (SLNs) using the thin-layer ultrasonication technique. Transmission electron microscopy (TEM), photon correlation spectro...

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Veröffentlicht in:Materials Science Forum 2006-03, Vol.510-511, p.170-173
Hauptverfasser: Liang, J.G., Liu, W., Xu, H.B., Yang, X.L., Zhu, Y.L., He, Z.K.
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container_title Materials Science Forum
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Liu, W.
Xu, H.B.
Yang, X.L.
Zhu, Y.L.
He, Z.K.
description Highly luminescent lipophilic CdSe/ZnS core-shell QDs with an emission maximum at 556 nm were synthesized. These QDs were successfully encapsulated into solid lipid nanoparticles (SLNs) using the thin-layer ultrasonication technique. Transmission electron microscopy (TEM), photon correlation spectroscopy (PCS), and zeta potential measurement were employed to characterize the QDs-loaded SLNs for morphology, particle size with polydispersity index (PI), and zeta potential. The nanocomposite particles obtained appeared in a shape of spherical or near spherical with the average size of 92.3 nm, PI of 0.235 and zeta potential of -28.74 mV. Each nanocomposite particle contains tens of QDs observed by TEM. Fluorescence measurements show that the encapsulated QDs maintain their high luminescence and narrow/symmetric emission spectra. The experiment result indicates that the nanocomposite particles are stable and slow to photobleach. These luminescent nanocomposite particles have good potentials in biological imaging applications.
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