Curcumin induces ferroptosis and apoptosis in osteosarcoma cells by regulating Nrf2/GPX4 signaling pathway

Curcumin, an antitumor agent, has been shown to inhibit cell growth and metastasis in osteosarcoma. However, there is no evidence of curcumin and its regulation of cell ferroptosis and nuclear factor E2–related factor 2 (Nrf2)/glutathione peroxidase 4 (GPX4) signaling pathways in osteosarcoma. This...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2023-12, Vol.248 (23), p.2183-2197
Hauptverfasser:	Yuan, Chuanjian, Fan, Rong, Zhu, Kai, Wang, Yutong, Xie, Wenpeng, Liang, Yanchen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bone Neoplasms - drug therapy Curcumin - pharmacology Disease Models, Animal Ferroptosis Humans Mice NF-E2-Related Factor 2 Osteosarcoma - drug therapy Signal Transduction
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