IL-13 and IL-13–induced periostin levels are specifically decreased in patients following endoscopic sinus surgery for chronic rhinosinusitis
[Display omitted] Type 2 (T2) inflammation plays a pathogenic role in chronic rhinosinusitis (CRS). The effects of endoscopic sinus surgery (ESS) on T2 inflammation are unknown. The aim of this study was to compare T2 inflammatory biomarkers from middle meatal (MM) mucus for distinguishing patients...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2024-05, Vol.153 (5), p.1292-1305 |
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| creator | Harmon, Regan Schneider, Alexander L. Bai, Junqin Racette, Samuel D. Reddy, Abhita T. Huang, Julia H. Lehmann, David S. Price, Caroline P.E. Rodeghiero, Samuel Agarwal, Aditi Eide, Jacob G. Dong, Siyuan Conley, David B. Welch, Kevin C. Kern, Robert C. Shintani-Smith, Stephanie Peters, Anju T. Kato, Atsushi Stevens, Whitney W. Muhammad, Lutfiyya N. Schleimer, Robert P. Tan, Bruce K. |
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Type 2 (T2) inflammation plays a pathogenic role in chronic rhinosinusitis (CRS). The effects of endoscopic sinus surgery (ESS) on T2 inflammation are unknown.
The aim of this study was to compare T2 inflammatory biomarkers from middle meatal (MM) mucus for distinguishing patients with CRS from CRS-free patients, identifying major phenotypes (CRS without nasal polyps [CRSsNP] and CRS with nasal polyps [CRSwNP]), assessing endotypic change, and establishing cross-sectional and longitudinal outcomes in patients undergoing ESS.
MM mucus samples were collected from patients with CRSsNP and patients with CRSwNP before and 6 to 12 months after ESS and compared with samples from CRS-free control patients. T2 biomarkers were evaluated both continuously and using threshold-based definitions of T2 endotype to identify relationships with patient-reported (based on the 22-Item Sinonasal Outcomes Test and Chronic Rhinosinusitis Patient-Reported Outcomes Measure) and clinician-reported (radiographic and endoscopic) severity. Linear mixed models were developed to analyze clinical variables associated with T2 biomarker levels.
A total of 154 patients with CRS (89 with CRSsNP and 65 with CRSwNP) were enrolled, with a mean interval of 9 months between ESS and follow-up. An analysis of pre-ESS MM mucus samples revealed elevated levels of T2 mediators in patients with CRSwNP versus in patients with CRSsNP and CRS-free controls. Temporally stable correlations between levels of IL-13 and IL-5, levels of periostin and complement 5a, and levels of eosinophil cationic protein (ECP) and eotaxin-3 were observed. On this basis and on the basis of pathologic significance, levels of IL-13, periostin and ECP were further analyzed. After ESS, levels of IL-13 and periostin decreased significantly, whereas ECP levels remained unchanged. Across pre- and post-ESS evaluation, the T2 endotype was associated with radiographic severity but did not predict outcomes. CRSwNP status and African American race were associated with higher levels of IL-13 and periostin, whereas ECP level was higher in patients undergoing extensive surgery.
ESS decreased levels of IL-13 and periostin in the middle meatus. T2 inflammation after ESS was correlated with patient- and clinician-reported severity across phenotypes. Pre-ESS T2 inflammation did not predict post-ESS outcomes. |
| doi_str_mv | 10.1016/j.jaci.2023.11.922 |
| format | Article |
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Type 2 (T2) inflammation plays a pathogenic role in chronic rhinosinusitis (CRS). The effects of endoscopic sinus surgery (ESS) on T2 inflammation are unknown.
The aim of this study was to compare T2 inflammatory biomarkers from middle meatal (MM) mucus for distinguishing patients with CRS from CRS-free patients, identifying major phenotypes (CRS without nasal polyps [CRSsNP] and CRS with nasal polyps [CRSwNP]), assessing endotypic change, and establishing cross-sectional and longitudinal outcomes in patients undergoing ESS.
MM mucus samples were collected from patients with CRSsNP and patients with CRSwNP before and 6 to 12 months after ESS and compared with samples from CRS-free control patients. T2 biomarkers were evaluated both continuously and using threshold-based definitions of T2 endotype to identify relationships with patient-reported (based on the 22-Item Sinonasal Outcomes Test and Chronic Rhinosinusitis Patient-Reported Outcomes Measure) and clinician-reported (radiographic and endoscopic) severity. Linear mixed models were developed to analyze clinical variables associated with T2 biomarker levels.
A total of 154 patients with CRS (89 with CRSsNP and 65 with CRSwNP) were enrolled, with a mean interval of 9 months between ESS and follow-up. An analysis of pre-ESS MM mucus samples revealed elevated levels of T2 mediators in patients with CRSwNP versus in patients with CRSsNP and CRS-free controls. Temporally stable correlations between levels of IL-13 and IL-5, levels of periostin and complement 5a, and levels of eosinophil cationic protein (ECP) and eotaxin-3 were observed. On this basis and on the basis of pathologic significance, levels of IL-13, periostin and ECP were further analyzed. After ESS, levels of IL-13 and periostin decreased significantly, whereas ECP levels remained unchanged. Across pre- and post-ESS evaluation, the T2 endotype was associated with radiographic severity but did not predict outcomes. CRSwNP status and African American race were associated with higher levels of IL-13 and periostin, whereas ECP level was higher in patients undergoing extensive surgery.
ESS decreased levels of IL-13 and periostin in the middle meatus. T2 inflammation after ESS was correlated with patient- and clinician-reported severity across phenotypes. Pre-ESS T2 inflammation did not predict post-ESS outcomes.</description><identifier>ISSN: 0091-6749</identifier><identifier>ISSN: 1097-6825</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2023.11.922</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>biomarker ; Chronic rhinosinusitis ; CRSsNP ; CRSwNP ; endotype ; nasal polyps ; patient-reported outcome measures</subject><ispartof>Journal of allergy and clinical immunology, 2024-05, Vol.153 (5), p.1292-1305</ispartof><rights>2024 American Academy of Allergy, Asthma & Immunology</rights><rights>Copyright © 2024 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c284t-7dc7dac282b29d76b281b40ccb0c93240e6b1a18aa3b1d376370e2bee10138343</cites><orcidid>0000-0001-9210-5050 ; 0009-0000-6106-2625</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091674923025423$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Harmon, Regan</creatorcontrib><creatorcontrib>Schneider, Alexander L.</creatorcontrib><creatorcontrib>Bai, Junqin</creatorcontrib><creatorcontrib>Racette, Samuel D.</creatorcontrib><creatorcontrib>Reddy, Abhita T.</creatorcontrib><creatorcontrib>Huang, Julia H.</creatorcontrib><creatorcontrib>Lehmann, David S.</creatorcontrib><creatorcontrib>Price, Caroline P.E.</creatorcontrib><creatorcontrib>Rodeghiero, Samuel</creatorcontrib><creatorcontrib>Agarwal, Aditi</creatorcontrib><creatorcontrib>Eide, Jacob G.</creatorcontrib><creatorcontrib>Dong, Siyuan</creatorcontrib><creatorcontrib>Conley, David B.</creatorcontrib><creatorcontrib>Welch, Kevin C.</creatorcontrib><creatorcontrib>Kern, Robert C.</creatorcontrib><creatorcontrib>Shintani-Smith, Stephanie</creatorcontrib><creatorcontrib>Peters, Anju T.</creatorcontrib><creatorcontrib>Kato, Atsushi</creatorcontrib><creatorcontrib>Stevens, Whitney W.</creatorcontrib><creatorcontrib>Muhammad, Lutfiyya N.</creatorcontrib><creatorcontrib>Schleimer, Robert P.</creatorcontrib><creatorcontrib>Tan, Bruce K.</creatorcontrib><title>IL-13 and IL-13–induced periostin levels are specifically decreased in patients following endoscopic sinus surgery for chronic rhinosinusitis</title><title>Journal of allergy and clinical immunology</title><description>[Display omitted]
Type 2 (T2) inflammation plays a pathogenic role in chronic rhinosinusitis (CRS). The effects of endoscopic sinus surgery (ESS) on T2 inflammation are unknown.
The aim of this study was to compare T2 inflammatory biomarkers from middle meatal (MM) mucus for distinguishing patients with CRS from CRS-free patients, identifying major phenotypes (CRS without nasal polyps [CRSsNP] and CRS with nasal polyps [CRSwNP]), assessing endotypic change, and establishing cross-sectional and longitudinal outcomes in patients undergoing ESS.
MM mucus samples were collected from patients with CRSsNP and patients with CRSwNP before and 6 to 12 months after ESS and compared with samples from CRS-free control patients. T2 biomarkers were evaluated both continuously and using threshold-based definitions of T2 endotype to identify relationships with patient-reported (based on the 22-Item Sinonasal Outcomes Test and Chronic Rhinosinusitis Patient-Reported Outcomes Measure) and clinician-reported (radiographic and endoscopic) severity. Linear mixed models were developed to analyze clinical variables associated with T2 biomarker levels.
A total of 154 patients with CRS (89 with CRSsNP and 65 with CRSwNP) were enrolled, with a mean interval of 9 months between ESS and follow-up. An analysis of pre-ESS MM mucus samples revealed elevated levels of T2 mediators in patients with CRSwNP versus in patients with CRSsNP and CRS-free controls. Temporally stable correlations between levels of IL-13 and IL-5, levels of periostin and complement 5a, and levels of eosinophil cationic protein (ECP) and eotaxin-3 were observed. On this basis and on the basis of pathologic significance, levels of IL-13, periostin and ECP were further analyzed. After ESS, levels of IL-13 and periostin decreased significantly, whereas ECP levels remained unchanged. Across pre- and post-ESS evaluation, the T2 endotype was associated with radiographic severity but did not predict outcomes. CRSwNP status and African American race were associated with higher levels of IL-13 and periostin, whereas ECP level was higher in patients undergoing extensive surgery.
ESS decreased levels of IL-13 and periostin in the middle meatus. T2 inflammation after ESS was correlated with patient- and clinician-reported severity across phenotypes. Pre-ESS T2 inflammation did not predict post-ESS outcomes.</description><subject>biomarker</subject><subject>Chronic rhinosinusitis</subject><subject>CRSsNP</subject><subject>CRSwNP</subject><subject>endotype</subject><subject>nasal polyps</subject><subject>patient-reported outcome measures</subject><issn>0091-6749</issn><issn>1097-6825</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kL1OHDEQx60oSLlAXoDKJc1u_LHsh5QGIQJIJ6WB2vLaczAnY288u6Dr8gYpeEOeBB-XOppiZjS__xQ_xk6lqKWQ7fdtvbUOayWUrqWsB6U-sZUUQ1e1vTr_zFZCDLJqu2b4wr4SbUXZdT-s2N_bdSU1t9Hzj-ntzytGvzjwfIKMiWaMPMAzBOI2A6cJHG7Q2RB23IPLYKmwBZrsjBBn4psUQnrB-MAh-kQuTeg4YVyI05IfIO8Kkrl7zCmWS37EmD7OOCOdsKONDQTf_vVjdv_z6u7yplr_ur69vFhXTvXNXHXedd6WWY1q8F07ql6OjXBuFG7QqhHQjtLK3lo9Sq-7VncC1AhQbOleN_qYnR3-Tjn9XoBm84TkIAQbIS1k1CBKyUbqgqoD6nIiyrAxU8Ynm3dGCrO3b7Zmb9_s7RspTbFfQj8OoSIOnhGyIVf0FK-Ywc3GJ_xf_B3nk5Fg</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Harmon, Regan</creator><creator>Schneider, Alexander L.</creator><creator>Bai, Junqin</creator><creator>Racette, Samuel D.</creator><creator>Reddy, Abhita T.</creator><creator>Huang, Julia H.</creator><creator>Lehmann, David S.</creator><creator>Price, Caroline P.E.</creator><creator>Rodeghiero, Samuel</creator><creator>Agarwal, Aditi</creator><creator>Eide, Jacob G.</creator><creator>Dong, Siyuan</creator><creator>Conley, David B.</creator><creator>Welch, Kevin C.</creator><creator>Kern, Robert C.</creator><creator>Shintani-Smith, Stephanie</creator><creator>Peters, Anju T.</creator><creator>Kato, Atsushi</creator><creator>Stevens, Whitney W.</creator><creator>Muhammad, Lutfiyya N.</creator><creator>Schleimer, Robert P.</creator><creator>Tan, Bruce K.</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9210-5050</orcidid><orcidid>https://orcid.org/0009-0000-6106-2625</orcidid></search><sort><creationdate>202405</creationdate><title>IL-13 and IL-13–induced periostin levels are specifically decreased in patients following endoscopic sinus surgery for chronic rhinosinusitis</title><author>Harmon, Regan ; Schneider, Alexander L. ; Bai, Junqin ; Racette, Samuel D. ; Reddy, Abhita T. ; Huang, Julia H. ; Lehmann, David S. ; Price, Caroline P.E. ; Rodeghiero, Samuel ; Agarwal, Aditi ; Eide, Jacob G. ; Dong, Siyuan ; Conley, David B. ; Welch, Kevin C. ; Kern, Robert C. ; Shintani-Smith, Stephanie ; Peters, Anju T. ; Kato, Atsushi ; Stevens, Whitney W. ; Muhammad, Lutfiyya N. ; Schleimer, Robert P. ; Tan, Bruce K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-7dc7dac282b29d76b281b40ccb0c93240e6b1a18aa3b1d376370e2bee10138343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>biomarker</topic><topic>Chronic rhinosinusitis</topic><topic>CRSsNP</topic><topic>CRSwNP</topic><topic>endotype</topic><topic>nasal polyps</topic><topic>patient-reported outcome measures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harmon, Regan</creatorcontrib><creatorcontrib>Schneider, Alexander L.</creatorcontrib><creatorcontrib>Bai, Junqin</creatorcontrib><creatorcontrib>Racette, Samuel D.</creatorcontrib><creatorcontrib>Reddy, Abhita T.</creatorcontrib><creatorcontrib>Huang, Julia H.</creatorcontrib><creatorcontrib>Lehmann, David S.</creatorcontrib><creatorcontrib>Price, Caroline P.E.</creatorcontrib><creatorcontrib>Rodeghiero, Samuel</creatorcontrib><creatorcontrib>Agarwal, Aditi</creatorcontrib><creatorcontrib>Eide, Jacob G.</creatorcontrib><creatorcontrib>Dong, Siyuan</creatorcontrib><creatorcontrib>Conley, David B.</creatorcontrib><creatorcontrib>Welch, Kevin C.</creatorcontrib><creatorcontrib>Kern, Robert C.</creatorcontrib><creatorcontrib>Shintani-Smith, Stephanie</creatorcontrib><creatorcontrib>Peters, Anju T.</creatorcontrib><creatorcontrib>Kato, Atsushi</creatorcontrib><creatorcontrib>Stevens, Whitney W.</creatorcontrib><creatorcontrib>Muhammad, Lutfiyya N.</creatorcontrib><creatorcontrib>Schleimer, Robert P.</creatorcontrib><creatorcontrib>Tan, Bruce K.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harmon, Regan</au><au>Schneider, Alexander L.</au><au>Bai, Junqin</au><au>Racette, Samuel D.</au><au>Reddy, Abhita T.</au><au>Huang, Julia H.</au><au>Lehmann, David S.</au><au>Price, Caroline P.E.</au><au>Rodeghiero, Samuel</au><au>Agarwal, Aditi</au><au>Eide, Jacob G.</au><au>Dong, Siyuan</au><au>Conley, David B.</au><au>Welch, Kevin C.</au><au>Kern, Robert C.</au><au>Shintani-Smith, Stephanie</au><au>Peters, Anju T.</au><au>Kato, Atsushi</au><au>Stevens, Whitney W.</au><au>Muhammad, Lutfiyya N.</au><au>Schleimer, Robert P.</au><au>Tan, Bruce K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-13 and IL-13–induced periostin levels are specifically decreased in patients following endoscopic sinus surgery for chronic rhinosinusitis</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><date>2024-05</date><risdate>2024</risdate><volume>153</volume><issue>5</issue><spage>1292</spage><epage>1305</epage><pages>1292-1305</pages><issn>0091-6749</issn><issn>1097-6825</issn><eissn>1097-6825</eissn><abstract>[Display omitted]
Type 2 (T2) inflammation plays a pathogenic role in chronic rhinosinusitis (CRS). The effects of endoscopic sinus surgery (ESS) on T2 inflammation are unknown.
The aim of this study was to compare T2 inflammatory biomarkers from middle meatal (MM) mucus for distinguishing patients with CRS from CRS-free patients, identifying major phenotypes (CRS without nasal polyps [CRSsNP] and CRS with nasal polyps [CRSwNP]), assessing endotypic change, and establishing cross-sectional and longitudinal outcomes in patients undergoing ESS.
MM mucus samples were collected from patients with CRSsNP and patients with CRSwNP before and 6 to 12 months after ESS and compared with samples from CRS-free control patients. T2 biomarkers were evaluated both continuously and using threshold-based definitions of T2 endotype to identify relationships with patient-reported (based on the 22-Item Sinonasal Outcomes Test and Chronic Rhinosinusitis Patient-Reported Outcomes Measure) and clinician-reported (radiographic and endoscopic) severity. Linear mixed models were developed to analyze clinical variables associated with T2 biomarker levels.
A total of 154 patients with CRS (89 with CRSsNP and 65 with CRSwNP) were enrolled, with a mean interval of 9 months between ESS and follow-up. An analysis of pre-ESS MM mucus samples revealed elevated levels of T2 mediators in patients with CRSwNP versus in patients with CRSsNP and CRS-free controls. Temporally stable correlations between levels of IL-13 and IL-5, levels of periostin and complement 5a, and levels of eosinophil cationic protein (ECP) and eotaxin-3 were observed. On this basis and on the basis of pathologic significance, levels of IL-13, periostin and ECP were further analyzed. After ESS, levels of IL-13 and periostin decreased significantly, whereas ECP levels remained unchanged. Across pre- and post-ESS evaluation, the T2 endotype was associated with radiographic severity but did not predict outcomes. CRSwNP status and African American race were associated with higher levels of IL-13 and periostin, whereas ECP level was higher in patients undergoing extensive surgery.
ESS decreased levels of IL-13 and periostin in the middle meatus. T2 inflammation after ESS was correlated with patient- and clinician-reported severity across phenotypes. Pre-ESS T2 inflammation did not predict post-ESS outcomes.</abstract><pub>Elsevier Inc</pub><doi>10.1016/j.jaci.2023.11.922</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-9210-5050</orcidid><orcidid>https://orcid.org/0009-0000-6106-2625</orcidid></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | biomarker Chronic rhinosinusitis CRSsNP CRSwNP endotype nasal polyps patient-reported outcome measures |
| title | IL-13 and IL-13–induced periostin levels are specifically decreased in patients following endoscopic sinus surgery for chronic rhinosinusitis |
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