Thymic stromal lymphopoietin induces IL-4/IL-13 from T cells to promote sebum secretion and adipose loss

[Display omitted] The cytokine TSLP promotes type 2 immune responses and can induce adipose loss by stimulating lipid loss from the skin through sebum secretion by sebaceous glands, which enhances the skin barrier. However, the mechanism by which TSLP upregulates sebaceous gland function is unknown....

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Veröffentlicht in:	Journal of allergy and clinical immunology 2024-08, Vol.154 (2), p.480-491
Hauptverfasser:	Choa, Ruth, Harris, Jordan C., Yang, EnJun, Yokoyama, Yuichi, Okumura, Mariko, Kim, MinJu, To, Jerrick, Lou, Meng, Nelson, Amanda, Kambayashi, Taku
Format:	Artikel
Sprache:	eng
Schlagworte:	adipose loss Adipose Tissue - immunology Adipose Tissue - metabolism Animals Cytokines - metabolism Humans IL-13 IL-4 Interleukin-13 - immunology Interleukin-13 - metabolism Interleukin-4 - immunology Interleukin-4 - metabolism Lipogenesis - immunology Mice Mice, Inbred C57BL Sebaceous gland Sebaceous Glands - immunology Sebaceous Glands - metabolism sebum Sebum - immunology Sebum - metabolism T cells T-Lymphocytes - immunology Thymic Stromal Lymphopoietin TSLP
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